Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-κB signalling pathways

International Immunopharmacology

Volumn 28, Issue 1, 2015, Pages 399-408

  Ma, Xiaobin ^a   Dang, Chengxue ^a   Kang, Huafeng ^a   Dai, Zhijun ^a   Lin, Shuai ^a   Guan, Haitao ^a   Liu, Xiaoxu ^a   Wang, Xijing ^a   Hui, Wentao ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Cisplatin nephrotoxicity; MAPKs; NF B; ROS; Saikosaponin D

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CASPASE 3; CISPLATIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; SAIKOSAPONIN D; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CYTOKINE; MESSENGER RNA; NOS2 PROTEIN, HUMAN; OLEANOLIC ACID; SAIKOSAPONIN; SAPONIN;

APOPTOSIS; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RENAL PROTECTION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; KIDNEY DISEASES; METABOLISM;

ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; CELL LINE; CELL SURVIVAL; CISPLATIN; CYTOKINES; HUMANS; KIDNEY DISEASES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OLEANOLIC ACID; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SAPONINS; SIGNAL TRANSDUCTION;

EID: 84938061461     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.06.020     Document Type: Article

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