Estrogen-like activities of saikosaponin-d in vitro: A pilot study

European Journal of Pharmacology

Volumn 626, Issue 2-3, 2010, Pages 159-165

  Wang, Peng ^a   Ren, Jianlin ^b   Tang, Jian ^a   Zhang, Dali ^a   Li, Bai ^c   Li, Yong ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Department of Medical Intelligence   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Estrogen receptor; Estrogen response element; Phytoestrogen; Saikosaponin d

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; LUCIFERASE; MESSENGER RNA; SAIKOSAPONIN D;

ARTICLE; BREAST CANCER; BUPLEURUM; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DOSE RESPONSE; DRUG STRUCTURE; ENZYME ACTIVITY; ESTROGEN ACTIVITY; ESTROGEN RESPONSIVE ELEMENT; HELA CELL; HUMAN; HUMAN CELL; PILOT STUDY; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA;

ANIMALS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; LUCIFERASES; OLEANOLIC ACID; PILOT PROJECTS; RESPONSE ELEMENTS; RNA, MESSENGER; SAPONINS; TRANSFECTION;

EID: 70649092057     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.09.047     Document Type: Article

References (23)

1. Atteritano M., Pernice F., Mazzaferro S., Mantuano S., Frisina A., D'Anna R., Cannata M.L., Bitto A., Squadrito F., Frisina N., and Buemi M. Effects of phytoestrogen genistein on cytogenetic biomarkers in postmenopausal women: 1 year randomized, placebo-controlled study. Eur. J. Pharmacol. 589 (2008) 22-26
2. Aoyagi H., Kobayashi Y., Yamada K., Yokoyama M., Kusakari K., and Tanaka H. Efficient production of saikosaponins in Bupleurum falcatum root fragments combined with signal transducers. Appl. Microbiol. Biotechnol. 57 (2001) 482-488
3. Barnes P.J. Corticosteroids: the drugs to beat. Eur. J. Pharmacol. 533 (2006) 2-14
4. Beck L.A., and Wade J. Steroid receptor expression in the developing copulatory system of the green anole lizard (Anolis carolinensis). Gen. Comp. Endocrinol. 157 (2008) 70-74
5. Brandi M.L. Phytoestrogens and menopause. Environ. Toxicol. Pharmacol. 7 (1999) 213-216
6. Brigitte G., and Johannes W. Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology 166 (2001) 79-89
7. Cuzick J. Hormone replacement therapy and the risk of breast cancer. Eur. J. Cancer 44 (2008) 2344-2349
8. Ding W.X., Qi X.R., Li P., Maitani Y., and Nagai T. Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d. Int. J. Pharm. 300 (2005) 38-47
9. Fox E.M., Davisb R.J., and Shupnik M.A. ERβ in breast cancer-onlooker, passive player, or active protector?. Steroids 73 (2008) 1039-1051
10. Hsu Y.L., Kuo P.L., and Lin C.C. The proliferative inhibition and apoptotic mechanism of saikosaponin D in human non-small cell lung cancer A549 cells. Life Sci. 75 (2004) 1231-1242
11. Ikegami F., Fujii Y., Ishihara K., and Satoh T. Toxicological aspects of Kampo medicines in clinical use. Chem.-Biol. Interact. 145 (2003) 235-250
12. Jawed S., Kim B., Ottenhof T., Brown G.M., Werstiuk E.S., and Niles L.P. Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation. Eur. J. Pharmacol. 560 (2007) 17-22
13. Leung C.Y., Liu L., Wong R.N.S., Zeng Y.Y., Li M., and Zhou H. Saikosaponin-d inhibits T cell activation through the modulation of PKCθ, JNK, and NF-κB transcription factor. Biochem. Biophys. Res. Commun. 338 (2005) 1920-1927
14. Maltais A., Remondetto G.E., and Subirade M. Soy protein cold-set hydrogels as controlled delivery devices for nutraceutical compounds. Food Hydrocoll. 23 (2009) 1647-1653
15. Meng Q.S., Zhu X.Y., Tang X.L., Ma B., and Ni X. Effect of isoflavones in regulating the transcription of target genes through estrogen receptors [in Chinese]. J. Chin. Integr. Med. 5 (2007) 577-580
16. Morinaga O., Zhu S.H., Tanaka H., and Shoyama Y. Visual detection of saikosaponins by on-membrane immunoassay and estimation of traditional Chinese medicines containing Bupleuri radix. Biochem. Biophys. Res. Commun. 346 (2006) 687-692
17. Mueller S.O. Overview of in vitro tools to assess the estrogenic and antiestrogenic activity of phytoestrogens. J. Chromatogr. B 777 (2002) 155-165
18. Ohtake N., Yamamoto M., Takeda S., Aburada M., Ishige A., Watanabe K., and Inoue M. The herbal medicine Sho-Saiko-To selectively inhibits CD8+ T-cell proliferation. Eur. J. Pharmacol. 507 (2005) 301-310
19. Scheid V. Traditional Chinese medicine-what are we investigating? The case of menopause. Complement. Ther. Med. 15 (2007) 54-68
20. Singhal R., Badger T.M., and Ronis M.J. Estrogenic status modulates the effect of soy on hepatic responses to 7, 12-dimethylbenz (a) anthracene (DMBA). Toxicol. Appl. Pharmcol. 234 (2009) 89-97
21. Yang Z.Y., Chao Z., Huo K.K., Xie H., Tian Z.P., and Pan S.L. ITS sequence analysis used for molecular identification of the Bupleurum species from northwestern China. Phytomedicine 14 (2007) 416-423
22. Zhao Y.Y., Luo H.S., Wang B., Ma L.B., Tu G.Z., and Zhang R.Y. Triterpenoid saponins from Bupleurum smithii var. parvifolium. Phytochemistry 42 (1996) 1673-1675
23. Zhu S., Shimokawa S., Shoyama Y., and Tanaka H. A novel analytical ELISA-based methodology for pharmacologically active saikosaponins. Fitoterapia 77 (2006) 100-108