Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis

Journal of Virology

Volumn 89, Issue 16, 2015, Pages 8416-8427

  Wang, Yi ^a   Sun, Ying ^b   Wu, Andong ^a   Xu, Shan ^a   Pan, Ruangang ^a   Zeng, Cong ^a   Jin, Xu ^a   Ge, Xingyi ^c   Shi, Zhengli ^c   Ahola, Tero ^d   Chen, Yu ^a   Guo, Deyin ^a  

^a WUHAN UNIVERSITY   (China)

^b HENAN UNIVERSITY OF CHINESE MEDICINE   (China)

^c WUHAN INSTITUTE OF VIROLOGY   (China)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLTRANSFERASE; METHYLTRANSFERASE INHIBITOR; NSP10 PROTEIN; NSP16 PROTEIN; TP 29; TP 29M; TP 29S; UNCLASSIFIED DRUG; VIRUS PROTEIN; ALANINE AMINOTRANSFERASE; LUCIFERASE; NSP10 PROTEIN, SARS VIRUS; NSP16 PROTEIN, SARS VIRUS; PEPTIDE; VIRAL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONAVIRIDAE; CORONAVIRUS INFECTION; CYTOKINE PRODUCTION; DRUG TARGETING; ENZYME ACTIVATION; FELINE CORONAVIRUS; IN VITRO STUDY; IN VIVO STUDY; INTRAHEPATIC DRUG ADMINISTRATION; MOUSE; MURINE HEPATITIS VIRUS; MURINE HEPATITIS VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REPLICON; SARS CORONAVIRUS; VIRUS INHIBITION; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; CELL LINE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; PATHOGENICITY;

CORONAVIRUS; EUKARYOTA; FELINE CORONAVIRUS; MURINE HEPATITIS VIRUS; MUS; SARS CORONAVIRUS;

ALANINE TRANSAMINASE; ANIMALS; CELL LINE; HUMANS; LUCIFERASES; METHYLTRANSFERASES; MICE; MURINE HEPATITIS VIRUS; PEPTIDES; RATS; SARS VIRUS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84938057765     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00948-15     Document Type: Article

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