Cell-based assays to detect inhibitors of fungal mRNA capping enzymes and characterization of sinefungin as a cap methyltransferase inhibitor

Journal of Biomolecular Screening

Volumn 10, Issue 4, 2005, Pages 355-364

  Chrebet, Gary L ^a   Wisniewski, Douglas ^a   Perkins, Ann L ^a   Deng, Qiaolin ^a   Kurtz, Myra B ^a   Marcy, Alice ^a   Parent, Stephen A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

(guanine 7 ) methyltransferase; Candida; mRNA cap; Sinefungin; Yeast

Indexed keywords

FUNGAL RNA; METHYLTRANSFERASE INHIBITOR; SINEFUNGIN;

ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG STRUCTURE; GENE EXPRESSION; GROWTH INHIBITION; HYBRID; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REPORTER GENE; RNA CAPPING; YEAST CELL;

ADENOSINE; AMINO ACID SEQUENCE; ENZYME INHIBITORS; GENES, REPORTER; MOLECULAR SEQUENCE DATA; NUCLEOTIDYLTRANSFERASES; PLASMIDS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID;

CANDIDA; EUKARYOTA; FUNGI; MAMMALIA;

EID: 20444415618     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/1087057104273333     Document Type: Article

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