Functional diversity of haloacid dehalogenase superfamily phosphatases from Saccharomyces cerevisiae: Biochemical, structural, and evolutionary insights

Journal of Biological Chemistry

Volumn 290, Issue 30, 2015, Pages 18678-18698

  Kuznetsova, Ekaterina ^a   Nocek, Boguslaw ^b   Brown, Greg ^a   Makarova, Kira S ^c   Flick, Robert ^a   Wolf, Yuri I ^c   Khusnutdinova, Anna ^a   Evdokimova, Elena ^a   Jin, Ke ^d   Tan, Kemin ^b   Hanson, Andrew D ^e   Hasnain, Ghulam ^e   Zallot, Rémi ^e   De Crécy Lagard, Valérie ^e   Babu, Mohan ^d   Savchenko, Alexei ^a   Joachimiak, Andrzej ^b   Edwards, Aled M ^a,b   Koonin, Eugene V ^c   Yakunin, Alexander F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF REGINA   (Canada)

^e UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CRYSTAL STRUCTURE; DETOXIFICATION; ESCHERICHIA COLI; METABOLITES; PHOSPHATASES; PHOSPHORYLATION; SUBSTRATES;

COMPOSITE SUBSTRATE; FUNCTIONAL DIVERSITY; HALOACID DEHALOGENASE; POTENTIAL ACTIVITIES; SACCHAROMYCES CEREVISIAE GENOME; SEQUENCE DIVERGENCES; STRUCTURAL FLEXIBILITIES; SUBSTRATE SPECIFICITY;

YEAST;

HALOACID; HALOACID DEHALOGENASE; PHO13 PROTEIN; PHOSPHATASE; PHOSPHATE METABOLISM PROTEIN 8; UNCLASSIFIED DRUG; YCR015C PROTEIN; YKL033W A PROTEIN; YKR070W PROTEIN; YNL010W PROTEIN; YOR131C PROTEIN; 2-HALOACID DEHALOGENASE; HYDROLASE;

BIOCHEMICAL ANALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; EVOLUTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BINDING SITE; CATALYSIS; CHEMISTRY; ENZYMOLOGY; FUNGAL GENOME; GENETICS; KINETICS; METABOLISM; MOLECULAR EVOLUTION; PHYLOGENY; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; GENOME, FUNGAL; HYDROLASES; KINETICS; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

EID: 84937939003     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.657916     Document Type: Review

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