Recent progress in understanding thiamin biosynthesis and its genetic regulation in Saccharomyces cerevisiae

Applied Microbiology and Biotechnology

Volumn 72, Issue 1, 2006, Pages 30-40

  Nosaka, Kazuto ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FERMENTED FOOD; GENETIC REGULATION; REGULATORY FACTOR COMPLEX; THIAMIN PYROPHOSPHATE (TPP);

BIOSYNTHESIS; ENZYMES; GENES; GENETIC ENGINEERING; MICROORGANISMS; MOLECULAR STRUCTURE;

PHOSPHATES;

PYRIMIDINE DERIVATIVE; THIAMINE; THIAMINE PHOSPHATE; THIAZOLE DERIVATIVE;

GENE EXPRESSION; VITAMIN; YEAST;

BIOSYNTHESIS; COMPLEX FORMATION; FERMENTED PRODUCT; FUNGAL GENE; GENE ACTIVATION; GENE CONTROL; GENE FUNCTION; GENE IDENTIFICATION; GENE INDUCTION; MULTIGENE FAMILY; NONHUMAN; PDC2 GENE; PET18 GENE; PHO3 GENE; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SHORT SURVEY; SNO2 GENE; SNO3 GENE; SNZ2 GENE; SNZ3 GENE; STARVATION; THI10 GENE; THI11 GENE; THI12 GENE; THI13 GENE; THI2 GENE; THI20 GENE; THI21 GENE; THI22 GENE; THI3 GENE; THI4 GENE; THI5 GENE; THI6 GENE; THI80 GENE; YEAST;

GENE EXPRESSION REGULATION, FUNGAL; MODELS, BIOLOGICAL; SACCHAROMYCES CEREVISIAE; THIAMINE;

SACCHAROMYCES CEREVISIAE;

EID: 33747108569     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-006-0464-9     Document Type: Short Survey

References (69)

1. Baker LJ, Dorocke JA, Harris RA, Timm DE (2001) The crystal structure of yeast thiamin pyrophosphokinase. Structure 9:539-546
2. Begley TP (1996) The biosynthesis and degradation of thiamin (vitamin B1). Nat Prod Rep 13:177-185
3. Begley TP, Downs DM, Ealick SE, McLafferty FW, Van Loon AP, Taylor S, Campobasso N, Chiu HJ, Kinsland C, Reddick JJ, Xi J (1999) Thiamin biosynthesis in prokaryotes. Arch Microbiol 171:293-300
4. Belitsky BR (2004) Physical and enzymological interaction of Bacillus subtilis proteins required for de novo pyridoxal 5′-phosphate biosynthesis. J Bacteriol 186:1191-1196
5. Braun EL, Fuge EK, Padilla PA, Werner-Washburne M (1996) A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family. J Bacteriol 178:6865-6872
6. Burdick R (1998) Thiamin. In: Howe-Grant M (ed) Kirk-Othmer encyclopedia of chemical technology, vol 25. Wiley, New York, pp 152-171
7. Burns KE, Xiang Y, Kinsland CL, McLafferty FW, Begley TP (2005) Reconstitution and biochemical characterization of a new pyridoxal 5′-phosphate biosynthetic pathway. J Am Chem Soc 127:3623-3682
8. Cheng G, Bennett EM, Begley TP, Ealick SE (2002) Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution. Structure 10:225-235
9. 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae. J Biol Chem 272:26871-26878
10. Dohmen RJ, Stappen R, McGrath JP, Forrova H, Kolarov J, Goffeau A, Varshavsky A (1995) An essential yeast gene encoding a homolog of ubiquitin-activating enzyme. J Biol Chem 270:18099-18109
11. Dong YX, Sueda S, Nikawa J, Kondo H (2004) Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae. Eur J Biochem 271:745-752
12. Dorrestein PC, Huili Zhai H, Taylor SV, McLafferty FW, Begley TP (2004) The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase. J Am Chem Soc 126:3091-3096
13. Enjo F, Nosaka K, Ogata M, Iwashima A, Nishimura H (1997) Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. J Biol Chem 272:19165-19170
14. Fankhauser H, Zurlinden A, Schweingruber AM, Edenharter E, Schweingruber ME (1995) Schizosaccharomyces pombe thiamin pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth. J Biol Chem 270:28457-28462
15. Faou P, Tropschug M (2003) A novel binding protein for a member of CyP40-type cyclophilins: N. crassa CyPBP37, a growth and thiamine regulated protein homolog to yeast Thi4p. J Mol Biol 333:831-844
16. Faou P, Tropschug M (2004) Neurospora crassa CyPBP37: a cytosolic stress protein that is able to replace yeast Thi4p function in the synthesis of vitamin B1. J Mol Biol s344:1147-1157
17. Friedrich W (1988) Vitamins. Walter de Gruyter, Berlin
18. Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG (1996) Life with 6000 genes. Science 274:563-567
19. Haas AL, Laun NP, Begley TP (2005) Thi20, a remarkable enzyme from Saccharomyces cerevisiae with dual thiamin biosynthetic and degradation activities. Bioorg Chem 33:338-344
20. Haj-Ahmad Y, Bilinski CA, Russell I, Stewart GG (1992) Thiamine secretion in yeast. Can J Microbiol 38:1156-1161
21. Harbison CT, Gordon DB, Lee TI, Rinaldi NJ, Macisaac KD, Danford TW, Hannett NM, Tagne JB, Reynolds DB, Yoo J, Jennings EG, Zeitlinger J, Pokholok DK, Kellis M, Rolfe PA, Takusagawa KT, Lander ES, Gifford DK, Fraenkel E, Young RA (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431:99-104
22. Hohmann S, Meacock PA (1998) Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation. Biochim Biophys Acta 1385:201-219
23. Iwashima A, Nishino H, Nose Y (1973) Carrier-mediated transport of thiamine in baker's yeast. Biochim Biophys Acta 330:222-234
24. Iwashima A, Nosaka K, Nishimura H, Kimura Y (1986) Some properties of a Saccharomyces cerevisiae mutant resistant to 2-amino-4-methyl-5-â- hydroxyethylthiazole. J Gen Microbiol 132:1541-1546
25. Iwashima A, Kawasaki Y, Kimura Y (1990a) Transport of 2-methyl-4-amino-5-hydroxymethylpyrimidine in Saccharomyces cerevisiae. Biochim Biophys Acta 1022:211-214
26. Iwashima A, Kawasaki Y, Kimura Y (1990b) Transport overshoot during 2-methyl-4-amino-5-hydroxymethylpyrimidine uptake by Saccharomyces cerevisiae. Biochim Biophys Acta 1028:161-164
27. Kawasaki Y (1993) Copurification of hydroxyethylthiazole kinase and thiamine-phosphate pyrophosphorylase of Saccharomyces cerevisiae: characterization of hydroxyethylthiazole kinase as a bifunctional enzyme in the thiamine biosynthetic pathway. J Bacteriol 175:5153-5158
28. Kawasaki Y, Nosaka K, Kaneko Y, Nishimura H, Iwashima A (1990) Regulation of thiamine biosynthesis in Saccharomyces cerevisiae. J Bacteriol 172:6145-6147
29. Kawasaki Y, Onozuka M, Mizote T, Nosaka K (2005) Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae. Curr Genet 47:156-162
30. Kimura Y, Iwashima A (1987) Occurrence of thiaminase II in Saccharomyces cerevisiae. Experientia 43:888-890
31. Kondo H, Nakata A, Horikawa N, Li Y, Sueda S (2004) Analysis of glutaminase activity involved in yeast pyridoxine biosynthesis. In: Proceedings for 56th meeting of the Vitamin Society of Japan. Vitamins (in Japanese), p 244
32. Lawhorn BG, Mehl RA, Begley TP (2004) Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction. Org Biomol Chem 2:2538-2546
33. Leonardi R, Roach PL (2004) Thiamine biosynthesis in Escherichia coli: in vitro reconstitution of the thiazole synthase activity. J Biol Chem 279:17054-17062
34. 15N)glycine in Saccharomyces cerevisiae. Biochem J 109:161-168
35. Llorente B, Dujon B (2000) Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w). FEBS Lett 475:237-241
36. Llorente B, Fairhead C, Dujon B (1999) Genetic redundancy and gene fusion in the genome of the baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway. Mol Microbiol 32:1140-1152
37. Machado CR, Praekelt UM, de Oliveira RC, Barbosa AC, Byrne KL, Meacock PA, Menck CF (1997) Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance. J Mol Biol 273:114-121
38. Marobbio CM, Vozza A, Harding M, Bisaccia F, Palmieri F, Walker JE (2002) Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate. EMBO J 21:5653-5661
39. Mayr C, Richter K, Lilie H, Buchner J (2000) Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties. J Biol Chem 275:34140-34146
40. McGrath JP, Jentsch S, Varshavsky A (1991) UBA1: an essential yeast gene encoding ubiquitin-activating enzyme. EMBO J 10:227-236
41. Medina-Silva R, Barros MP, Galhardo RS, Netto LE, Colepicolo P, Menck CF (2005) Heat stress promotes mitochondrial instability and oxidative responses in yeast deficient in thiazole biosynthesis. Res Microbiol 157(3):275-281
42. Mittenhuber G (2001) Phylogenetic analyses and comparative genomics of vitamin B6 (pyridoxine) and pyridoxal phosphate biosynthesis pathways. J Mol Microbiol Biotechnol 3:1-20
43. Morett E, Korbel JO, Rajan E, Saab-Rincon G, Olvera L, Olvera M, Schmidt S, Snel B, Bork P (2003) Systematic discovery of analogous enzymes in thiamin biosynthesis. Nat Biotechnol 21:790-795
44. Muller EH, Richards EJ, Norbeck J, Byrne KL, Karlsson KA, Pretorius GHJ, Meacock PA, Blomberg A, Hohmann S (1999) Thiamine repression and pyruvate decarboxylase autoregulation independently control the expression of the Saccharomyces cerevisiae PDC5 gene. FEBS Lett 449:245-250
45. Nakai Y, Umeda N, Suzuki T, Nakai M, Hayashi H, Watanabe K, Kagamiyama H (2004) Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs. J Biol Chem 279:12363-12368
46. Nishimura H, Kawasaki Y, Nosaka K, Kaneko Y, Iwashima A (1991) A constitutive thiamine metabolism mutation, thi80, causing reduced thiamine pyrophosphokinase activity in Saccharomyces cerevisiae. J Bacteriol 173:2716-2719
47. Nosaka K, Kaneko Y, Nishimura H, Iwashima A (1989) A possible role for acid phosphatase with thiamin-binding activity encoded by PHO3 in yeast. FEMS Microbiol Lett 51:55-59
48. Nosaka K, Yamanishi K, Nishimura H, Iwashima A (1992) Upstream activation element of the PHO3 gene encoding for thiamine-repressible acid phosphatase in Saccharomyces cerevisiae. FEBS Lett 305:244-248
49. Nosaka K, Kaneko Y, Nishimura H, Iwashima A (1993) Isolation and characterization of a thiamin pyrophosphokinase gene, THI80, from Saccharomyces cerevisiae. J Biol Chem 268:17440-17447
50. Nosaka K, Nishimura H, Kawasaki Y, Tsujihara T, Iwashima A (1994) Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae. J Biol Chem 269:30510-30516
51. Nosaka K, Onozuka M, Konno H, Kawasaki Y, Nishimura H, Sano M, Akaji K (2005) Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae. Mol Microbiol 58:467-479
52. Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP (2003) Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry 42:12430-12438
53. Praekelt UM, Byrne KL, Meacock PA (1994) Regulation of THI4 (MOL1), a thiamin-biosynthetic gene of Saccharomyces cerevisiae. Yeast 10:481-490
54. Rodriguez-Navarro S, Llorente B, Rodriguez-Manzaneque MT, Ramne A, Uber G, Marchesan D, Dujon B, Herrero E, Sunnerhagen P, Perez-Ortin JE (2002) Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6. Yeast 19:1261-1276
55. Schweingruber AM, Fankhauser H, Dlugonski J, Steinmann-Loss C, Schweingruber ME (1992) Isolation and characterization of regulatory mutants from Schizosaccharomyces pombe involved in thiamine-regulated gene expression. Genetics 130:445-449
56. Silhankova L (1985a) Yeast mutants excreting vitamin B1 and their use in the production of thiamin rich beers. J Inst Brew 91:78-81
57. Silhankova L (1985b) Genetic control of thiamin excretion and of its suppression in Saccharomyces cerevisiae. J Inst Brew 91:238-241
58. Singleton CK (1997) Identification and characterization of the thiamine transporter gene of Saccharomyces cerevisiae. Gene 199:111-121
59. Spenser ID, White RL (1997) Biosynthesis of vitamin B1 (thiamin): an instance of biochemical diversity. Angew Chem Int Ed Engl 36:1032-1046
60. Tazuya K, Yamada K, Nakamura K, Kumaoka H (1987) The origin of the sulfur atom of thiamin. Biochim Biophys Acta 924:210-215
61. Tazuya K, Yamada K, Kumaoka H (1989) Incorporation of histidine into the pyrimidine moiety of thiamin in Saccharomyces cerevisiae. Biochim Biophys Acta 990:73-79
62. Tazuya K, Yamada K, Kumaoka H (1993) Pyridoxine is a precursor of the pyrimidine moiety of thiamin in Saccharomyces cerevisiae. Biochem Mol Biol Int 30:893-899
63. Toms AV, Haas AL, Park JH, Begley TP, Ealick SE (2005) Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry 44:2319-2329
64. Watanabe-Ishida S, Tazuya K, Yamada K (2005) Precursor of the pyrimidine moiety of thiamin in Saccharomyces cerevisiae. In: Proceedings for international interdisciplinary conference on vitamins, coenzymes, and biofactors 2005. The Vitamin Society of Japan, Kyoto, pp 70
65. Wightman R, Meacock PA (2003) The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine. Microbiol 149:1447-1460
66. White RL, Spenser ID (1979) Thiamin biosynthesis in Saccharomyces cerevisiae. Origin of carbon-2 of the thiazole moiety. Biochem J 179:315-325
67. White RL, Spenser ID (1982) Thiamin biosynthesis in yeast. Origin of the five-carbon unit of the thiazole moiety. J Am Chem Soc 104:4934-4943
68. Xi J, Ge Y, Kinsland C, McLafferty FW, Begley TP (2001) Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: identification of an acyldisulfide-linked protein-protein conjugate that is functionally analogous to the ubiquitin/E1 complex. Proc Natl Acad Sci USA 98:8513-8518
69. Zeidler J, Sayer BG, Spenser ID (2003) Biosynthesis of vitamin B1 in yeast. Derivation of the pyrimidine unit from pyridoxine and histidine. Intermediacy of urocanic acid. J Am Chem Soc 125:13094-13105