Divergence of structure and function in the haloacid dehalogenase enzyme superfamily: Bacteroides thetaiotaomicron BT2127 Is an inorganic pyrophosphatase

Biochemistry

Volumn 50, Issue 41, 2011, Pages 8937-8949

  Huang, Hua ^a   Patskovsky, Yury ^b   Toro, Rafael ^b   Farelli, Jeremiah D ^c   Pandya, Chetanya ^d   Almo, Steven C ^b   Allen, Karen N ^c   Dunaway Mariano, Debra ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c USA   (United States)

^d BOSTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BACTEROIDES THETAIOTAOMICRON; BIOINFORMATIC ANALYSIS; CATALYTIC RESIDUE; DEHALOGENASE; ENZYME SUPERFAMILIES; EXPERIMENTAL APPROACHES; FUNCTION ASSIGNMENT; FUNCTION PREDICTION; HALOACID DEHALOGENASE; IN-VIVO; INORGANIC PYROPHOSPHATASES; KINETIC ANALYSIS; LEAVING GROUPS; METAL-BINDING RESIDUES; MUTANT ENZYMES; ORTHOLOGUES; PHOSPHOGLUCOMUTASE; PROTEIN SEQUENCES; PYROPHOSPHATASES; SEQUENCE MARKERS; SITE DIRECTED MUTAGENESIS; STEADY-STATE RATE CONSTANTS; STRUCTURAL DETERMINANTS; STRUCTURE-FUNCTION ANALYSIS; SUBSTRATE BINDING; SUBSTRATE DISCRIMINATION; SUBSTRATE SPECIFICITY; UNIPROT; WILD TYPES; X RAY STRUCTURAL ANALYSIS;

ENZYMES; GENES; GLUCOSE; MUTAGENESIS; RATE CONSTANTS; STRUCTURAL ANALYSIS;

BIOINFORMATICS;

4 NITROPHENYL PHOSPHATE; ASPARTIC ACID DERIVATIVE; BACTERIAL PROTEIN; BT2127 PROTEIN; FRUCTOSE 6 PHOSPHATE; GLUCOSE PHOSPHATE; GLYCEROPHOSPHATE; INORGANIC PYROPHOSPHATASE; LYSINE DERIVATIVE; PHOSPHATASE; PHOSPHOGLUCOMUTASE; PYROPHOSPHATE; RIBOSE 5 PHOSPHATE; UNCLASSIFIED DRUG; URIDINE PHOSPHATE;

ARTICLE; BACTEROIDES THETAIOTAOMICRON; BIOCATALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS;

BACTEROIDES; BIOCHEMISTRY; CATALYTIC DOMAIN; HYDROGEN-ION CONCENTRATION; HYDROLASES; KINETICS; MODELS, MOLECULAR; MUTATION; PHOSPHOGLUCOMUTASE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PYROPHOSPHATASES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; X-RAY DIFFRACTION;

BACTERIA (MICROORGANISMS); BACTEROIDES THETAIOTAOMICRON;

EID: 80054717981     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201181q     Document Type: Article

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