2-Methoxy-1,4-naphthoquinone (MNQ) induces apoptosis of A549 lung adenocarcinoma cells via oxidation-triggered JNK and p38 MAPK signaling pathways

Life Sciences

Volumn 135, Issue , 2015, Pages 158-164

  Ong, Jeremy Yee Hoong ^a   Yong, Phelim Voon Chen ^a   Lim, Yang Mooi ^b   Ho, Anthony Siong Hock ^a  

^a TAYLOR S UNIVERSITY   (Malaysia)

^b UNIVERSITI TUNKU ABDUL RAHMAN   (Malaysia)

Author keywords

2 Methoxy 1,4 naphthoquinone (MNQ); Lung adenocarcinoma; Mitogen activated protein kinase (MAPK); Reactive oxygen species (ROS)

Indexed keywords

1,4 NAPHTHOQUINONE; 2 METHOXY 1,4 NAPHTHOQUINONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; DICHLORODIHYDROFLUORESCEIN DIACETATE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SULFORHODAMINE B; UNCLASSIFIED DRUG; 2-METHOXY-1,4-NAPHTHOQUINONE; CYTOTOXIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NAPHTHOQUINONE; TUMOR PROTEIN;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CANCER INHIBITION; CANCER THERAPY; CELL CYCLE ARREST; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DEATH; DNA DAMAGE; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC50; LUNG ADENOCARCINOMA; OXIDATION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ADENOCARCINOMA; CELL CYCLE CHECKPOINT; DRUG EFFECTS; ENZYMOLOGY; LUNG NEOPLASMS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYTOTOXINS; DNA DAMAGE; HUMANS; LUNG NEOPLASMS; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; NAPHTHOQUINONES; NEOPLASM PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 84937929130     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.03.019     Document Type: Article

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