-
1
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R., et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N. Engl. J. Med. 2005, 352(17):1779-1790.
-
(2005)
N. Engl. J. Med.
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
-
2
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C., et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005, 434(7037):1144-1148.
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
-
3
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine R.L., et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005, 7(4):387-397.
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
-
4
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter E.J., et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005, 365(9464):1054-1061.
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
-
5
-
-
20744460045
-
Identification of an acquired JAK2 mutation in polycythemia vera
-
Zhao R., et al. Identification of an acquired JAK2 mutation in polycythemia vera. J. Biol. Chem. 2005, 280(24):22788-22792.
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.24
, pp. 22788-22792
-
-
Zhao, R.1
-
6
-
-
21344467318
-
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
-
Jones A.V., et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood 2005, 106(6):2162-2168.
-
(2005)
Blood
, vol.106
, Issue.6
, pp. 2162-2168
-
-
Jones, A.V.1
-
8
-
-
84883497454
-
Glutamine and cancer: cell biology, physiology, and clinical opportunities
-
Hensley C.T., Wasti A.T., DeBerardinis R.J. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J. Clin. Invest. 2013, 123(9):3678-3684.
-
(2013)
J. Clin. Invest.
, vol.123
, Issue.9
, pp. 3678-3684
-
-
Hensley, C.T.1
Wasti, A.T.2
DeBerardinis, R.J.3
-
9
-
-
0001572284
-
Nutrition needs of mammalian cells in tissue culture
-
Eagle H. Nutrition needs of mammalian cells in tissue culture. Science 1955, 122(3168):501-514.
-
(1955)
Science
, vol.122
, Issue.3168
, pp. 501-514
-
-
Eagle, H.1
-
10
-
-
0000045991
-
The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid
-
Eagle H., et al. The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid. J. Biol. Chem. 1956, 218(2):607-616.
-
(1956)
J. Biol. Chem.
, vol.218
, Issue.2
, pp. 607-616
-
-
Eagle, H.1
-
11
-
-
0038050529
-
Interorgan amino acid transport and its regulation
-
Brosnan J.T. Interorgan amino acid transport and its regulation. J. Nutr. 2003, 133(6 Suppl 1):2068S-2072S.
-
(2003)
J. Nutr.
, vol.133
, Issue.6
, pp. 2068S-2072S
-
-
Brosnan, J.T.1
-
12
-
-
64749116346
-
C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
Gao P., et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458(7239):762-765.
-
(2009)
Nature
, vol.458
, Issue.7239
, pp. 762-765
-
-
Gao, P.1
-
13
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise D.R., et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(48):18782-18787.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, Issue.48
, pp. 18782-18787
-
-
Wise, D.R.1
-
14
-
-
75149148563
-
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
-
DeBerardinis R.J., Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010, 29(3):313-324.
-
(2010)
Oncogene
, vol.29
, Issue.3
, pp. 313-324
-
-
DeBerardinis, R.J.1
Cheng, T.2
-
15
-
-
84855453655
-
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
-
Le A., et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012, 15(1):110-121.
-
(2012)
Cell Metab.
, vol.15
, Issue.1
, pp. 110-121
-
-
Le, A.1
-
16
-
-
84867424108
-
Therapeutic targeting of Myc-reprogrammed cancer cell metabolism
-
Dang C.V. Therapeutic targeting of Myc-reprogrammed cancer cell metabolism. Cold Spring Harb. Symp. Quant. Biol. 2011, 76:369-374.
-
(2011)
Cold Spring Harb. Symp. Quant. Biol.
, vol.76
, pp. 369-374
-
-
Dang, C.V.1
-
18
-
-
84860406094
-
The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity
-
Reddy M.M., et al. The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity. Leukemia 2012, 26(3):481-489.
-
(2012)
Leukemia
, vol.26
, Issue.3
, pp. 481-489
-
-
Reddy, M.M.1
-
19
-
-
84873272524
-
MicroRNA deregulation in polycythemia vera and essential thrombocythemia patients
-
Zhan H., et al. MicroRNA deregulation in polycythemia vera and essential thrombocythemia patients. Blood Cells Mol. Dis. 2013, 50(3):190-195.
-
(2013)
Blood Cells Mol. Dis.
, vol.50
, Issue.3
, pp. 190-195
-
-
Zhan, H.1
-
20
-
-
84897903692
-
A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis
-
Etheridge S.L., et al. A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis. Blood 2014, 123(7):1059-1068.
-
(2014)
Blood
, vol.123
, Issue.7
, pp. 1059-1068
-
-
Etheridge, S.L.1
-
21
-
-
77949525475
-
Ubiquitination and degradation of the thrombopoietin receptor c-Mpl
-
Saur S.J., et al. Ubiquitination and degradation of the thrombopoietin receptor c-Mpl. Blood 2010, 115(6):1254-1263.
-
(2010)
Blood
, vol.115
, Issue.6
, pp. 1254-1263
-
-
Saur, S.J.1
-
22
-
-
33750611344
-
Involvement of various hematopoietic-cell lineages by the JAK2V617F mutation in polycythemia vera
-
Ishii T., et al. Involvement of various hematopoietic-cell lineages by the JAK2V617F mutation in polycythemia vera. Blood 2006, 108(9):3128-3134.
-
(2006)
Blood
, vol.108
, Issue.9
, pp. 3128-3134
-
-
Ishii, T.1
-
23
-
-
33846012829
-
JAK2(V617F): prevalence in a large Chinese hospital population
-
Xu X., et al. JAK2(V617F): prevalence in a large Chinese hospital population. Blood 2007, 109(1):339-342.
-
(2007)
Blood
, vol.109
, Issue.1
, pp. 339-342
-
-
Xu, X.1
-
24
-
-
37449034854
-
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis R.J., et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(49):19345-19350.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, Issue.49
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
-
25
-
-
84930392977
-
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
-
Xiang Y., et al. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J. Clin. Invest. 2015, 125(6):2293-2306.
-
(2015)
J. Clin. Invest.
, vol.125
, Issue.6
, pp. 2293-2306
-
-
Xiang, Y.1
-
26
-
-
0014481891
-
The proportionality of glutaminase content to growth rate and morphology of rat neoplasms
-
Knox W.E., Horowitz M.L., Friedell G.H. The proportionality of glutaminase content to growth rate and morphology of rat neoplasms. Cancer Res. 1969, 29(3):669-680.
-
(1969)
Cancer Res.
, vol.29
, Issue.3
, pp. 669-680
-
-
Knox, W.E.1
Horowitz, M.L.2
Friedell, G.H.3
-
27
-
-
0014524860
-
Glutaminase activities and growth rates of rat hepatomas
-
Linder-Horowitz M., Knox W.E., Morris H.P. Glutaminase activities and growth rates of rat hepatomas. Cancer Res. 1969, 29(6):1195-1199.
-
(1969)
Cancer Res.
, vol.29
, Issue.6
, pp. 1195-1199
-
-
Linder-Horowitz, M.1
Knox, W.E.2
Morris, H.P.3
-
28
-
-
15944391333
-
Co-expression of glutaminase K and L isoenzymes in human tumour cells
-
Perez-Gomez C., et al. Co-expression of glutaminase K and L isoenzymes in human tumour cells. Biochem. J. 2005, 386(Pt 3):535-542.
-
(2005)
Biochem. J.
, vol.386
, pp. 535-542
-
-
Perez-Gomez, C.1
-
29
-
-
34548789512
-
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)
-
Robinson M.M., et al. Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES). Biochem. J. 2007, 406(3):407-414.
-
(2007)
Biochem. J.
, vol.406
, Issue.3
, pp. 407-414
-
-
Robinson, M.M.1
-
30
-
-
77956497712
-
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
-
Wang J.B., et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 2010, 18(3):207-219.
-
(2010)
Cancer Cell
, vol.18
, Issue.3
, pp. 207-219
-
-
Wang, J.B.1
-
31
-
-
33845436745
-
The myeloproliferative disorders
-
Campbell P.J., Green A.R. The myeloproliferative disorders. N. Engl. J. Med. 2006, 355(23):2452-2466.
-
(2006)
N. Engl. J. Med.
, vol.355
, Issue.23
, pp. 2452-2466
-
-
Campbell, P.J.1
Green, A.R.2
-
32
-
-
34547936938
-
The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera
-
Dupont S., et al. The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera. Blood 2007, 110(3):1013-1021.
-
(2007)
Blood
, vol.110
, Issue.3
, pp. 1013-1021
-
-
Dupont, S.1
-
33
-
-
84866633441
-
JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone
-
Godfrey A.L., et al. JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone. Blood 2012, 120(13):2704-2707.
-
(2012)
Blood
, vol.120
, Issue.13
, pp. 2704-2707
-
-
Godfrey, A.L.1
-
34
-
-
77953857654
-
Sex differences in the JAK2 V617F allele burden in chronic myeloproliferative disorders
-
Stein B.L., et al. Sex differences in the JAK2 V617F allele burden in chronic myeloproliferative disorders. Haematologica 2010, 95(7):1090-1097.
-
(2010)
Haematologica
, vol.95
, Issue.7
, pp. 1090-1097
-
-
Stein, B.L.1
-
35
-
-
84857837774
-
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
-
Harrison C., et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N. Engl. J. Med. 2012, 366(9):787-798.
-
(2012)
N. Engl. J. Med.
, vol.366
, Issue.9
, pp. 787-798
-
-
Harrison, C.1
-
36
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
Verstovsek S., et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N. Engl. J. Med. 2012, 366(9):799-807.
-
(2012)
N. Engl. J. Med.
, vol.366
, Issue.9
, pp. 799-807
-
-
Verstovsek, S.1
-
37
-
-
78549283855
-
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1
-
Seltzer M.J., et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res. 2010, 70(22):8981-8987.
-
(2010)
Cancer Res.
, vol.70
, Issue.22
, pp. 8981-8987
-
-
Seltzer, M.J.1
-
38
-
-
84870982915
-
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors
-
Shukla K., et al. Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J. Med. Chem. 2012, 55(23):10551-10563.
-
(2012)
J. Med. Chem.
, vol.55
, Issue.23
, pp. 10551-10563
-
-
Shukla, K.1
-
39
-
-
84901714382
-
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis
-
Rampal R., et al. Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis. Blood 2014, 123(22):e123-e133.
-
(2014)
Blood
, vol.123
, Issue.22
, pp. e123-e133
-
-
Rampal, R.1
-
40
-
-
80051651725
-
Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms
-
Anand S., et al. Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms. Blood 2011, 118(6):1610-1621.
-
(2011)
Blood
, vol.118
, Issue.6
, pp. 1610-1621
-
-
Anand, S.1
-
41
-
-
84909584695
-
JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis
-
Wang X., et al. JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis. Blood 2014, 124(19):2987-2995.
-
(2014)
Blood
, vol.124
, Issue.19
, pp. 2987-2995
-
-
Wang, X.1
-
42
-
-
84890372480
-
Somatic mutations of calreticulin in myeloproliferative neoplasms
-
Klampfl T., et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N. Engl. J. Med. 2013, 369(25):2379-2390.
-
(2013)
N. Engl. J. Med.
, vol.369
, Issue.25
, pp. 2379-2390
-
-
Klampfl, T.1
-
43
-
-
84890328032
-
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
-
Nangalia J., et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N. Engl. J. Med. 2013, 369(25):2391-2405.
-
(2013)
N. Engl. J. Med.
, vol.369
, Issue.25
, pp. 2391-2405
-
-
Nangalia, J.1
-
44
-
-
84904645105
-
Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer
-
Gross M.I., et al. Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol. Cancer Ther. 2014, 13(4):890-901.
-
(2014)
Mol. Cancer Ther.
, vol.13
, Issue.4
, pp. 890-901
-
-
Gross, M.I.1
-
45
-
-
84867130104
-
Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth
-
van den Heuvel A.P., et al. Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth. Cancer Biol. Ther. 2012, 13(12):1185-1194.
-
(2012)
Cancer Biol. Ther.
, vol.13
, Issue.12
, pp. 1185-1194
-
-
van den Heuvel, A.P.1
-
46
-
-
84899089555
-
Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations
-
Emadi A., et al. Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations. Exp. Hematol. 2014, 42(4):247-251.
-
(2014)
Exp. Hematol.
, vol.42
, Issue.4
, pp. 247-251
-
-
Emadi, A.1
|