Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases

Chemistry and Biology

Volumn 22, Issue 7, 2015, Pages 928-937

  Cognetta, Armand B ^a   Niphakis, Micah J ^a   Lee, Hyeon Cheol ^a   Martini, Michael L ^a   Hulce, Jonathan J ^a   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC 16; ABC 23; ABC 34; ABC 37; ABC 38; ABC 44; ABC 45; ABC 47; ABC 5; ABC 51; ABHD3 PROTEIN; ABHD4 PROTEIN; HYDROLASE; HYDROLASE INHIBITOR; JJH 221; JJH 251; JJH 254; MJN 193; N HYDROXYHYDANTOIN CARBAMATE INHIBITOR; PALMITOYL PROTEIN THIOESTERASE; PALMITOYL PROTEIN THIOESTERASE 1; PROTEIN; SERINE HYDROLASE; UNCLASSIFIED DRUG; CARBAMIC ACID DERIVATIVE; PALMITOYL-PROTEIN THIOESTERASE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; THIOL ESTER HYDROLASE;

ANIMAL EXPERIMENT; ARTICLE; CARBAMOYLATION; CONTROLLED STUDY; CROSS REACTION; DRUG DEVELOPMENT; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC50; IN VIVO STUDY; MOUSE; MUTATION; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; HEK293 CELL LINE; METABOLISM;

MAMMALIA;

ANIMALS; CARBAMATES; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; THIOLESTER HYDROLASES;

EID: 84937784363     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.05.018     Document Type: Article

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