Pyruvate metabolism: A therapeutic opportunity in radiation-induced skin injury

Biochemical and Biophysical Research Communications

Volumn 460, Issue 3, 2015, Pages 504-510

  Yoo, Hyun ^a   Kang, Jeong Wook ^a   Lee, Dong Won ^a   Oh, Sang Ho ^a   Lee, Yun Sil ^b   Lee, Eun Jung ^a   Cho, Jaeho ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

Pyruvate dehydrogenase kinase; Radiation; Skin injury

Indexed keywords

CYTOKINE; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; PYRUVIC ACID DERIVATIVE;

3T3 CELL LINE; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; INJURIES; METABOLISM; MOUSE; RADIATION INJURIES, EXPERIMENTAL; RADIATION RESPONSE; REAL TIME POLYMERASE CHAIN REACTION; SKIN;

ANIMALS; CYTOKINES; GENE EXPRESSION REGULATION; MICE; NIH 3T3 CELLS; PROTEIN-SERINE-THREONINE KINASES; PYRUVATES; RADIATION INJURIES, EXPERIMENTAL; REAL-TIME POLYMERASE CHAIN REACTION; SKIN;

EID: 84937760321     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.03.060     Document Type: Article

References (29)

1. J.H. Kim, A.J. Kolozsvary, K.A. Jenrow, and S.L. Brown Mechanisms of radiation-induced skin injury and implications for future clinical trials Int. J. Radiat. Biol. 89 2013 311 318
2. J.L. Ryan Ionizing radiation: the good, the bad, and the ugly J. Invest. Dermatol. 132 2012 985 993
3. C. Nieder, F.B. Zimmermann, M. Adam, and M. Molls The role of pentoxifylline as a modifier of radiation therapy Cancer Treat. Rev. 31 2005 448 455
4. J.L. Lefaix, S. Delanian, M.C. Vozenin, J.J. Leplat, Y. Tricaud, and M. Martin Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: an experimental study Int. J. Radiat. Oncol. Biol. Phys. 43 1999 839 847
5. R.J. DeBerardinis, A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff, S. Wehrli, and C.B. Thompson Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis Proc. Natl. Acad. Sci. U. S. A. 104 2007 19345 19350
6. M.C. Sugden, and M.J. Holness Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases Arch. Physiol. Biochem. 112 2006 139 149
7. M.S. Patel, and L.G. Korotchkina Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases Exp. Mol. Med. 33 2001 191 197
8. M.M. Bowker-Kinley, W.I. Davis, P. Wu, R.A. Harris, and K.M. Popov Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex Biochem. J. 329 Pt 1 1998 191 196
9. A.M. Bolger, M. Lohse, and B. Usadel Trimmomatic: a flexible trimmer for illumina sequence data Bioinformatics 30 2014 2114 2120
10. C. Trapnell, L. Pachter, and S.L. Salzberg TopHat: discovering splice junctions with RNA-Seq Bioinformatics 25 2009 1105 1111
11. H. Li, B. Handsaker, A. Wysoker, T. Fennell, J. Ruan, N. Homer, G. Marth, G. Abecasis, and R. Durbin S. Genome project data processing, the sequence alignment/map format and SAMtools Bioinformatics 25 2009 2078 2079
12. S. Anders HTSeq: Analysing High-throughput Sequencing Data with Python 2010 http://www-huber.embl.de/users/anders/HTSeq/doc/overview.html
13. S. Anders Analysing RNA-Seq data with the DESeq package Mol. Biol. 2010 1 17
14. W. Huang da, B.T. Sherman, and R.A. Lempicki Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Nat. Protoc. 4 2009 44 57
15. C.M. Ma, C.W. Coffey, L.A. DeWerd, C. Liu, R. Nath, S.M. Seltzer, J.P. Seuntjens, and M. American Association of Physicists AAPM protocol for 40-300 kV X-ray beam dosimetry in radiotherapy and radiobiology Med. Phys. 28 2001 868 893
16. V.D. Thanik, C.C. Chang, R.A. Zoumalan, O.Z. Lerman, R.J. Allen Jr., P.D. Nguyen, S.M. Warren, S.R. Coleman, and A. Hazen A novel mouse model of cutaneous radiation injury Plastic Reconstr. Surg. 127 2011 560 568
17. S.K. Gupta, S. Rastogi, J. Prakash, S. Joshi, Y.K. Gupta, L. Awor, and S.D. Verma Anti-inflammatory activity of sodium pyruvate-a physiological antioxidant Indian J. Physiol. Pharmacol. 44 2000 101 104
18. G.N. Neigh, S.D. Bilbo, A.K. Hotchkiss, and R.J. Nelson Exogenous pyruvate prevents stress-evoked suppression of mitogen-stimulated proliferation Brain Behav. Immun. 18 2004 425 433
19. K.H. Sit, Y.K. Lau, and S.E. Aw Differential oxygen sensitivities in G6PDH activities of cultured keloid and normal skin dermis single cells J. Dermatol. 18 1991 572 579
20. N. Yevdokimova, and S. Podpryatov The up-regulation of angiotensin II receptor type 1 and connective tissue growth factor are involved in high-glucose-induced fibronectin production by cultured human dermal fibroblasts J. Dermatol. Sci. 47 2007 127 139
21. A.S. Vincent, T.T. Phan, A. Mukhopadhyay, H.Y. Lim, B. Halliwell, and K.P. Wong Human skin keloid fibroblasts display bioenergetics of cancer cells J. Invest. Dermatol. 128 2008 702 709
22. F. Zwicker, A. Kirsner, P. Peschke, F. Roeder, J. Debus, P.E. Huber, and K.J. Weber Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo Strahlenther. Onkol. Organ Dtsch. Rontgengesellschaft. 189 2013 684 692
23. W. Saleem, Y. Suzuki, A. Mobaraki, Y. Yoshida, S. Noda, J.I. Saitoh, and T. Nakano Reduction of nitric oxide level enhances the radiosensitivity of hypoxic non-small cell lung cancer Cancer Sci. 102 2011 2150 2156
24. M.P. Fink Ethyl pyruvate: a novel anti-inflammatory agent J. Intern. Med. 261 2007 349 362
25. K.K. Kao, and M.P. Fink The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds Biochem. Pharmacol. 80 2010 151 159
26. Y. Takakusagi, S. Matsumoto, K. Saito, M. Matsuo, S. Kishimoto, J.W. Wojtkowiak, W. DeGraff, A.H. Kesarwala, R. Choudhuri, N. Devasahayam, S. Subramanian, J.P. Munasinghe, R.J. Gillies, J.B. Mitchell, C.P. Hart, and M.C. Krishna Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302 PloS One 9 2014 e107995
27. R. Aoki, A. Aoki-Yoshida, C. Suzuki, and Y. Takayama Protective effect of indole-3-pyruvate against ultraviolet b-induced damage to cultured HaCaT keratinocytes and the skin of hairless mice PloS One 9 2014 e96804
28. A. Aoki-Yoshida, R. Aoki, and Y. Takayama Protective effect of pyruvate against UVB-induced damage in HaCaT human keratinocytes J. Biosci. Bioeng. 115 2013 442 448
29. J.Y. Lee, Y.H. Kim, and J.Y. Koh Protection by pyruvate against transient forebrain ischemia in rats J. Neurosci. Off. J. Soc. Neurosci. 21 2001 RC171