메뉴 건너뛰기




Volumn 232, Issue 15, 2015, Pages 2811-2825

2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons

Author keywords

AM404; Anandamide; CB1; CB2; Fear extinction; JZL184; TRPV1; URB597

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 ARACHIDONOYLGLYCEROL; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 AMINOBUTYRIC ACID RECEPTOR; 4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; 4 [BIS(1,3 BENZODIOXOL 5 YL)HYDROXYMETHYL] 1 PIPERIDINECARBOXYLIC ACID 4 NITROPHENYL ESTER; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; N (4 HYDROXY 2 METHYLPHENYL)ARACHIDONAMIDE; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; RIMONABANT; 2-ARACHIDONYLGLYCEROL; ACYLGLYCEROL; AMIDE; ARACHIDONIC ACID DERIVATIVE; CANNABINOID; CANNABINOID RECEPTOR ANTAGONIST; ENDOCANNABINOID; N-(2-METHYL-3-HYDROXYPHENYL)-5,8,11,14-EICOSATETRAENAMIDE; N-(4-HYDROXYPHENYL)ARACHIDONYLAMIDE; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

EID: 84937726636     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-015-3917-y     Document Type: Article
Times cited : (93)

References (96)
  • 2
    • 79957551226 scopus 로고    scopus 로고
    • Supply and demand for endocannabinoids
    • Alger BE, Kim J (2011) Supply and demand for endocannabinoids. Trends Neurosci 34:304-315. doi: 10.1016/j.tins.2011.03.003
    • (2011) Trends Neurosci , vol.34 , pp. 304-315
    • Alger, B.E.1    Kim, J.2
  • 3
    • 84878246519 scopus 로고    scopus 로고
    • Monoacylglycerol lipase inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity in male CD1 mice
    • Aliczki M, Zelena D, Mikics E, Varga ZK, Pinter O, Bakos NV et al (2013) Monoacylglycerol lipase inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity in male CD1 mice. Horm Behav 63:752-758. doi: 10.1016/j.yhbeh.2013.03.017
    • (2013) Horm Behav , vol.63 , pp. 752-758
    • Aliczki, M.1    Zelena, D.2    Mikics, E.3    Varga, Z.K.4    Pinter, O.5    Bakos, N.V.6
  • 4
    • 84879132067 scopus 로고    scopus 로고
    • Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray
    • Almeida-Santos AF, Gobira PH, Rosa LC, Guimaraes FS, Moreira FA, Aguiar DC (2013) Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray. Behav Brain Res 252:10-17. doi: 10.1016/j.bbr.2013.05.027
    • (2013) Behav Brain Res , vol.252 , pp. 10-17
    • Almeida-Santos, A.F.1    Gobira, P.H.2    Rosa, L.C.3    Guimaraes, F.S.4    Moreira, F.A.5    Aguiar, D.C.6
  • 5
    • 84863185677 scopus 로고    scopus 로고
    • Fear extinction and BDNF: Translating animal models of PTSD to the clinic
    • Andero R, Ressler KJ (2012) Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes Brain Behav 11:503-512. doi: 10.1111/j.1601-183X.2012.00801.x
    • (2012) Genes Brain Behav , vol.11 , pp. 503-512
    • Andero, R.1    Ressler, K.J.2
  • 6
    • 77952623444 scopus 로고    scopus 로고
    • CB2: A cannabinoid receptor with an identity crisis
    • Atwood BK, Mackie K (2010) CB2: a cannabinoid receptor with an identity crisis. Br J Pharmacol 160:467-479
    • (2010) Br J Pharmacol , vol.160 , pp. 467-479
    • Atwood, B.K.1    Mackie, K.2
  • 7
  • 8
    • 0034720298 scopus 로고    scopus 로고
    • Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol
    • 1:CAS:528:DC%2BD3cXjslSksL0%3D 10817598
    • Beltramo M, Piomelli D (2000) Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol. Neuroreport 11:1231-1235
    • (2000) Neuroreport , vol.11 , pp. 1231-1235
    • Beltramo, M.1    Piomelli, D.2
  • 9
    • 0034850220 scopus 로고    scopus 로고
    • The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors
    • 1:CAS:528:DC%2BD3MXivVarsrk%3D 11277920
    • Bisogno T, MacCarrone M, De Petrocellis L, Jarrahian A, Finazzi-Agrò A, Hillard C et al (2001) The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. Eur J Biochem 268:1982-1989
    • (2001) Eur J Biochem , vol.268 , pp. 1982-1989
    • Bisogno, T.1    MacCarrone, M.2    De Petrocellis, L.3    Jarrahian, A.4    Finazzi-Agrò, A.5    Hillard, C.6
  • 10
    • 53649087673 scopus 로고    scopus 로고
    • Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats
    • Bitencourt RM, Pamplona FA, Takahashi RN (2008) Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats. Eur Neuropsychopharmacol 18:849-859. doi: 10.1016/j.euroneuro.2008.07.001
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 849-859
    • Bitencourt, R.M.1    Pamplona, F.A.2    Takahashi, R.N.3
  • 11
    • 80051473369 scopus 로고    scopus 로고
    • Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses
    • Busquets-Garcia A, Puighermanal E, Pastor A, de la Torre R, Maldonado R, Ozaita A (2011) Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. Biol Psychiatry 70:479-486. doi: 10.1016/j.biopsych.2011.04.022
    • (2011) Biol Psychiatry , vol.70 , pp. 479-486
    • Busquets-Garcia, A.1    Puighermanal, E.2    Pastor, A.3    De La Torre, R.4    Maldonado, R.5    Ozaita, A.6
  • 12
    • 13944267958 scopus 로고    scopus 로고
    • Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear
    • Chhatwal JP, Davis M, Maguschak KA, Ressler KJ (2005) Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear. Neuropsychopharmacology 30:516-524. doi: 10.1038/sj.npp.1300655
    • (2005) Neuropsychopharmacology , vol.30 , pp. 516-524
    • Chhatwal, J.P.1    Davis, M.2    Maguschak, K.A.3    Ressler, K.J.4
  • 13
    • 84866418810 scopus 로고    scopus 로고
    • A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: Potential extinction enhancers
    • de Bitencourt RM, Pamplona FA, Takahashi RN (2013) A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers. Neuropharmacology 64:389-395. doi: 10.1016/j.neuropharm.2012.05.039
    • (2013) Neuropharmacology , vol.64 , pp. 389-395
    • De Bitencourt, R.M.1    Pamplona, F.A.2    Takahashi, R.N.3
  • 14
    • 0034644842 scopus 로고    scopus 로고
    • Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: Inhibitors of anandamide uptake with negligible capsaicin-like activity
    • 11033355
    • De Petrocellis L, Bisogno T, Davis JB, Pertwee RG, Di Marzo V (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett 483:52-56
    • (2000) FEBS Lett , vol.483 , pp. 52-56
    • De Petrocellis, L.1    Bisogno, T.2    Davis, J.B.3    Pertwee, R.G.4    Di Marzo, V.5
  • 15
    • 84885601005 scopus 로고    scopus 로고
    • Targeted mutagenesis tools for modelling psychiatric disorders
    • Deussing JM (2013) Targeted mutagenesis tools for modelling psychiatric disorders. Cell Tissue Res 354:9-25. doi: 10.1007/s00441-013-1708-5
    • (2013) Cell Tissue Res , vol.354 , pp. 9-25
    • Deussing, J.M.1
  • 16
    • 84907466163 scopus 로고    scopus 로고
    • CB2 Cannabinoid receptors as a therapeutic target - What does the future hold?
    • Dhopeshwarkar A, Mackie K (2014) CB2 Cannabinoid receptors as a therapeutic target - what does the future hold? Mol Pharmacol 86:430-437. doi: 10.1124/mol.114.094649
    • (2014) Mol Pharmacol , vol.86 , pp. 430-437
    • Dhopeshwarkar, A.1    Mackie, K.2
  • 17
    • 78650641401 scopus 로고    scopus 로고
    • Endocannabinoid signaling in the brain: Biosynthetic mechanisms in the limelight
    • Di Marzo V (2011) Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. Nat Neurosci 14:9-15. doi: 10.1038/nn.2720
    • (2011) Nat Neurosci , vol.14 , pp. 9-15
    • Di Marzo, V.1
  • 19
    • 84856087132 scopus 로고    scopus 로고
    • A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneurons
    • Edwards JG, Gibson HE, Jensen T, Nugent F, Walther C, Blickenstaff J et al (2012) A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneurons. Hippocampus 22:209-221. doi: 10.1002/hipo.20884
    • (2012) Hippocampus , vol.22 , pp. 209-221
    • Edwards, J.G.1    Gibson, H.E.2    Jensen, T.3    Nugent, F.4    Walther, C.5    Blickenstaff, J.6
  • 20
    • 84859444756 scopus 로고    scopus 로고
    • Anandamide uptake explained?
    • Fowler CJ (2012) Anandamide uptake explained? Trends Pharmacol Sci 33:181-185. doi: 10.1016/j.tips.2012.01.001
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 181-185
    • Fowler, C.J.1
  • 21
    • 84876947593 scopus 로고    scopus 로고
    • Transport of endocannabinoids across the plasma membrane and within the cell
    • Fowler CJ (2013) Transport of endocannabinoids across the plasma membrane and within the cell. FEBS J 280:1895-1904. doi: 10.1111/febs.12212
    • (2013) FEBS J , vol.280 , pp. 1895-1904
    • Fowler, C.J.1
  • 22
    • 84555198880 scopus 로고    scopus 로고
    • A catalytically silent FAAH-1 variant drives anandamide transport in neurons
    • Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M et al (2012) A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat Neurosci 15:64-69. doi: 10.1038/nn.2986
    • (2012) Nat Neurosci , vol.15 , pp. 64-69
    • Fu, J.1    Bottegoni, G.2    Sasso, O.3    Bertorelli, R.4    Rocchia, W.5    Masetti, M.6
  • 23
    • 84883653545 scopus 로고    scopus 로고
    • Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit
    • Ganon-Elazar E, Akirav I (2013) Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit. Psychoneuroendocrinology 38:1675-1687. doi: 10.1016/j.psyneuen.2013.01.014
    • (2013) Psychoneuroendocrinology , vol.38 , pp. 1675-1687
    • Ganon-Elazar, E.1    Akirav, I.2
  • 24
    • 76649137560 scopus 로고    scopus 로고
    • Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice
    • Gao Y, Vasilyev DV, Goncalves MB, Howell FV, Hobbs C, Reisenberg M et al (2010) Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J Neurosci 30:2017-2024. doi: 10.1523/JNEUROSCI. 5693-09.2010
    • (2010) J Neurosci , vol.30 , pp. 2017-2024
    • Gao, Y.1    Vasilyev, D.V.2    Goncalves, M.B.3    Howell, F.V.4    Hobbs, C.5    Reisenberg, M.6
  • 26
    • 70349782163 scopus 로고    scopus 로고
    • Consequences of extinction training on associative and non-associative fear in a mouse model of posttraumatic stress disorder (PTSD)
    • Golub Y, Mauch CP, Dahlhoff M, Wotjak CT (2009) Consequences of extinction training on associative and non-associative fear in a mouse model of posttraumatic stress disorder (PTSD). Behav Brain Res 205:544-549. doi: 10.1016/j.bbr.2009.08.019
    • (2009) Behav Brain Res , vol.205 , pp. 544-549
    • Golub, Y.1    Mauch, C.P.2    Dahlhoff, M.3    Wotjak, C.T.4
  • 27
    • 84855327357 scopus 로고    scopus 로고
    • The study of fear extinction: Implications for anxiety disorders
    • Graham BM, Milad MR (2011) The study of fear extinction: implications for anxiety disorders. Am J Psychiatry 168:1255-1265. doi: 10.1176/appi.ajp.2011.11040557
    • (2011) Am J Psychiatry , vol.168 , pp. 1255-1265
    • Graham, B.M.1    Milad, M.R.2
  • 28
    • 3242751838 scopus 로고    scopus 로고
    • Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala
    • Gulyas AI, Cravatt BF, Bracey MH, Dinh TP, Piomelli D, Boscia F et al (2004) Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Eur J Neurosci 20:441-458. doi: 10.1111/j.1460-9568.2004.03428.x
    • (2004) Eur J Neurosci , vol.20 , pp. 441-458
    • Gulyas, A.I.1    Cravatt, B.F.2    Bracey, M.H.3    Dinh, T.P.4    Piomelli, D.5    Boscia, F.6
  • 29
    • 84887406857 scopus 로고    scopus 로고
    • Amygdala FAAH and anandamide: Mediating protection and recovery from stress
    • Gunduz-Cinar O, Hill MN, McEwen BS, Holmes A (2013a) Amygdala FAAH and anandamide: mediating protection and recovery from stress. Trends Pharmacol Sci 34:637-644. doi: 10.1016/j.tips.2013.08.008
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 637-644
    • Gunduz-Cinar, O.1    Hill, M.N.2    McEwen, B.S.3    Holmes, A.4
  • 30
    • 84879412059 scopus 로고    scopus 로고
    • Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity
    • Gunduz-Cinar O, MacPherson KP, Cinar R, Gamble-George J, Sugden K, Williams B et al (2013b) Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. Mol Psychiatry 18:813-823. doi: 10.1038/mp.2012.72
    • (2013) Mol Psychiatry , vol.18 , pp. 813-823
    • Gunduz-Cinar, O.1    MacPherson, K.P.2    Cinar, R.3    Gamble-George, J.4    Sugden, K.5    Williams, B.6
  • 31
    • 4043145966 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors mediate anxiolytic effects: Convergent genetic and pharmacological evidence with CB1-specific agents
    • 1:CAS:528:DC%2BD2cXls1agtbg%3D 15252281
    • Haller J, Varga B, Ledent C, Freund TF (2004) CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents. Behav Pharmacol 15:299-304
    • (2004) Behav Pharmacol , vol.15 , pp. 299-304
    • Haller, J.1    Varga, B.2    Ledent, C.3    Freund, T.F.4
  • 32
    • 84863244650 scopus 로고    scopus 로고
    • Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD
    • Han J, Kesner P, Metna-Laurent M, Duan T, Xu L, Georges F et al (2012) Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell 148:1039-1050. doi: 10.1016/j.cell.2012.01.037
    • (2012) Cell , vol.148 , pp. 1039-1050
    • Han, J.1    Kesner, P.2    Metna-Laurent, M.3    Duan, T.4    Xu, L.5    Georges, F.6
  • 33
    • 67349186927 scopus 로고    scopus 로고
    • Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function
    • Hariri AR, Gorka A, Hyde LW, Kimak M, Halder I, Ducci F et al (2009) Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function. Biol Psychiatry 66:9-16. doi: 10.1016/j.biopsych.2008.10.047
    • (2009) Biol Psychiatry , vol.66 , pp. 9-16
    • Hariri, A.R.1    Gorka, A.2    Hyde, L.W.3    Kimak, M.4    Halder, I.5    Ducci, F.6
  • 34
    • 33846795915 scopus 로고    scopus 로고
    • Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus
    • Hashimotodani Y, Ohno-Shosaku T, Kano M (2007) Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus. J Neurosci 27:1211-1219. doi: 10.1523/JNEUROSCI. 4159-06.2007
    • (2007) J Neurosci , vol.27 , pp. 1211-1219
    • Hashimotodani, Y.1    Ohno-Shosaku, T.2    Kano, M.3
  • 36
    • 84869751850 scopus 로고    scopus 로고
    • In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice
    • Heldt SA, Mou L, Ressler KJ (2012) In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice. Transl Psychiatry 2:e181. doi: 10.1038/tp.2012.101
    • (2012) Transl Psychiatry , vol.2 , pp. e181
    • Heldt, S.A.1    Mou, L.2    Ressler, K.J.3
  • 37
    • 78149485984 scopus 로고    scopus 로고
    • Functional interactions between stress and the endocannabinoid system: From synaptic signaling to behavioral output
    • Hill MN, Patel S, Campolongo P, Tasker JG, Wotjak CT, Bains JS (2010) Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output. J Neurosci 30:14980-14986. doi: 10.1523/JNEUROSCI. 4283-10.2010
    • (2010) J Neurosci , vol.30 , pp. 14980-14986
    • Hill, M.N.1    Patel, S.2    Campolongo, P.3    Tasker, J.G.4    Wotjak, C.T.5    Bains, J.S.6
  • 38
    • 84922741113 scopus 로고    scopus 로고
    • Stress regulates endocannabinoid-CB1 receptor signaling
    • Hillard CJ (2014) Stress regulates endocannabinoid-CB1 receptor signaling. Semin Immunol. doi: 10.1016/j.smim.2014.04.001
    • (2014) Semin Immunol
    • Hillard, C.J.1
  • 39
    • 84857125719 scopus 로고    scopus 로고
    • Contributions of endocannabinoid signaling to psychiatric disorders in humans: Genetic and biochemical evidence
    • Hillard CJ, Weinlander KM, Stuhr KL (2012) Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. Neuroscience 204:207-229. doi: 10.1016/j.neuroscience.2011.11.020
    • (2012) Neuroscience , vol.204 , pp. 207-229
    • Hillard, C.J.1    Weinlander, K.M.2    Stuhr, K.L.3
  • 40
    • 84871720291 scopus 로고    scopus 로고
    • Individual differences in recovery from traumatic fear
    • Holmes A, Singewald N (2013) Individual differences in recovery from traumatic fear. Trends Neurosci 36:23-31. doi: 10.1016/j.tins.2012.11.003
    • (2013) Trends Neurosci , vol.36 , pp. 23-31
    • Holmes, A.1    Singewald, N.2
  • 41
    • 70349685317 scopus 로고    scopus 로고
    • Endocannabinoids render exploratory behaviour largely independent of the test aversiveness: Role of glutamatergic transmission
    • Jacob W, Yassouridis A, Marsicano G, Monory K, Lutz B, Wotjak CT (2009) Endocannabinoids render exploratory behaviour largely independent of the test aversiveness: role of glutamatergic transmission. Genes Brain Behav 8:685-698. doi: 10.1111/j.1601-183X.2009.00512.x
    • (2009) Genes Brain Behav , vol.8 , pp. 685-698
    • Jacob, W.1    Yassouridis, A.2    Marsicano, G.3    Monory, K.4    Lutz, B.5    Wotjak, C.T.6
  • 42
    • 84863086326 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo
    • Jacob W, Marsch R, Marsicano G, Lutz B, Wotjak CT (2012) Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo. Neurobiol Learn Mem 98:47-55. doi: 10.1016/j.nlm.2012.04.008
    • (2012) Neurobiol Learn Mem , vol.98 , pp. 47-55
    • Jacob, W.1    Marsch, R.2    Marsicano, G.3    Lutz, B.4    Wotjak, C.T.5
  • 43
    • 10044272343 scopus 로고    scopus 로고
    • Nonassociative learning processes determine expression and extinction of conditioned fear in mice
    • Kamprath K, Wotjak CT (2004) Nonassociative learning processes determine expression and extinction of conditioned fear in mice. Learn Mem 11:770-786. doi: 10.1101/lm.86104
    • (2004) Learn Mem , vol.11 , pp. 770-786
    • Kamprath, K.1    Wotjak, C.T.2
  • 44
    • 33745768020 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes
    • Kamprath K, Marsicano G, Tang J, Monory K, Bisogno T, Di Marzo V et al (2006) Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes. J Neurosci 26:6677-6686. doi: 10.1523/JNEUROSCI. 0153-06.2006
    • (2006) J Neurosci , vol.26 , pp. 6677-6686
    • Kamprath, K.1    Marsicano, G.2    Tang, J.3    Monory, K.4    Bisogno, T.5    Di Marzo, V.6
  • 45
    • 61449264779 scopus 로고    scopus 로고
    • Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling
    • Kamprath K, Plendl W, Marsicano G, Deussing JM, Wurst W, Lutz B et al (2009) Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling. Genes Brain Behav 8:203-211. doi: 10.1111/j.1601-183X.2008.00463.x
    • (2009) Genes Brain Behav , vol.8 , pp. 203-211
    • Kamprath, K.1    Plendl, W.2    Marsicano, G.3    Deussing, J.M.4    Wurst, W.5    Lutz, B.6
  • 48
    • 3042785976 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus
    • Kim J, Alger BE (2004) Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. Nat Neurosci 7:697-698. doi: 10.1038/nn1262
    • (2004) Nat Neurosci , vol.7 , pp. 697-698
    • Kim, J.1    Alger, B.E.2
  • 49
    • 78650619344 scopus 로고    scopus 로고
    • Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay
    • Kinsey SG, O'Neal ST, Long JZ, Cravatt BF, Lichtman AH (2011) Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. Pharmacol Biochem Behav 98:21-27. doi: 10.1016/j.pbb.2010.12.002
    • (2011) Pharmacol Biochem Behav , vol.98 , pp. 21-27
    • Kinsey, S.G.1    O'Neal, S.T.2    Long, J.Z.3    Cravatt, B.F.4    Lichtman, A.H.5
  • 50
    • 70350237015 scopus 로고    scopus 로고
    • Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system
    • Lafenêtre P, Chaouloff F, Marsicano G (2009) Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system. Neuropharmacology 57:715-721. doi: 10.1016/j.neuropharm.2009.07.014
    • (2009) Neuropharmacology , vol.57 , pp. 715-721
    • Lafenêtre, P.1    Chaouloff, F.2    Marsicano, G.3
  • 51
    • 80052966544 scopus 로고    scopus 로고
    • Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour
    • Llorente-Berzal A, Fuentes S, Gagliano H, López-Gallardo M, Armario A, Viveros MP et al (2011) Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour. Addict Biol 16:624-637. doi: 10.1111/j.1369-1600.2011.00318.x
    • (2011) Addict Biol , vol.16 , pp. 624-637
    • Llorente-Berzal, A.1    Fuentes, S.2    Gagliano, H.3    López-Gallardo, M.4    Armario, A.5    Viveros, M.P.6
  • 52
    • 57749087828 scopus 로고    scopus 로고
    • Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
    • Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE et al (2009) Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol 5:37-44. doi: 10.1038/nchembio.129
    • (2009) Nat Chem Biol , vol.5 , pp. 37-44
    • Long, J.Z.1    Li, W.2    Booker, L.3    Burston, J.J.4    Kinsey, S.G.5    Schlosburg, J.E.6
  • 53
    • 84868035924 scopus 로고    scopus 로고
    • Anandamide and 2-arachidonoylglycerol: Pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids
    • Luchicchi A, Pistis M (2012) Anandamide and 2-arachidonoylglycerol: pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids. Mol Neurobiol 46:374-392. doi: 10.1007/s12035-012-8299-0
    • (2012) Mol Neurobiol , vol.46 , pp. 374-392
    • Luchicchi, A.1    Pistis, M.2
  • 54
    • 38649097877 scopus 로고    scopus 로고
    • Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum
    • Maccarrone M, Rossi S, Bari M, De Chiara V, Fezza F, Musella A et al (2008) Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. Nat Neurosci 11:152-159. doi: 10.1038/nn2042
    • (2008) Nat Neurosci , vol.11 , pp. 152-159
    • MacCarrone, M.1    Rossi, S.2    Bari, M.3    De Chiara, V.4    Fezza, F.5    Musella, A.6
  • 55
    • 33644766044 scopus 로고    scopus 로고
    • Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors
    • Maione S, Bisogno T, de Novellis V, Palazzo E, Cristino L, Valenti M et al (2006) Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. J Pharmacol Exp Ther 316:969-982. doi: 10.1124/jpet.105.093286
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 969-982
    • Maione, S.1    Bisogno, T.2    De Novellis, V.3    Palazzo, E.4    Cristino, L.5    Valenti, M.6
  • 56
    • 84883100383 scopus 로고    scopus 로고
    • Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics
    • Maione S, Costa B, Piscitelli F, Morera E, De Chiaro M, Comelli F et al (2013) Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics. Pharmacol Res 76C:98-105. doi: 10.1016/j.phrs.2013.07.003
    • (2013) Pharmacol Res , vol.76 , pp. 98-105
    • Maione, S.1    Costa, B.2    Piscitelli, F.3    Morera, E.4    De Chiaro, M.5    Comelli, F.6
  • 57
    • 70349214696 scopus 로고    scopus 로고
    • FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats
    • Manwell LA, Satvat E, Lang ST, Allen CP, Leri F, Parker LA (2009) FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats. Pharmacol Biochem Behav 94:154-162. doi: 10.1016/j.pbb.2009.08.002
    • (2009) Pharmacol Biochem Behav , vol.94 , pp. 154-162
    • Manwell, L.A.1    Satvat, E.2    Lang, S.T.3    Allen, C.P.4    Leri, F.5    Parker, L.A.6
  • 58
    • 33846636000 scopus 로고    scopus 로고
    • Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice
    • Marsch R, Foeller E, Rammes G, Bunck M, Kössl M, Holsboer F et al (2007) Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J Neurosci 27:832-839. doi: 10.1523/JNEUROSCI. 3303-06.2007
    • (2007) J Neurosci , vol.27 , pp. 832-839
    • Marsch, R.1    Foeller, E.2    Rammes, G.3    Bunck, M.4    Kössl, M.5    Holsboer, F.6
  • 59
    • 0033452718 scopus 로고    scopus 로고
    • Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain
    • 1:STN:280:DC%2BD3c%2Fmt1Crug%3D%3D 10594647
    • Marsicano G, Lutz B (1999) Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain. Eur J Neurosci 11:4213-4225
    • (1999) Eur J Neurosci , vol.11 , pp. 4213-4225
    • Marsicano, G.1    Lutz, B.2
  • 60
    • 0036682222 scopus 로고    scopus 로고
    • The endogenous cannabinoid system controls extinction of aversive memories
    • Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG et al (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530-534. doi: 10.1038/nature00839
    • (2002) Nature , vol.418 , pp. 530-534
    • Marsicano, G.1    Wotjak, C.T.2    Azad, S.C.3    Bisogno, T.4    Rammes, G.5    Cascio, M.G.6
  • 61
    • 0030005172 scopus 로고    scopus 로고
    • Aversive effects of the synthetic cannabinoid CP 55,940 in rats
    • 1:CAS:528:DyaK28XhsVCltbk%3D 8866969
    • McGregor IS, Issakidis CN, Prior G (1996) Aversive effects of the synthetic cannabinoid CP 55,940 in rats. Pharmacol Biochem Behav 53:657-664
    • (1996) Pharmacol Biochem Behav , vol.53 , pp. 657-664
    • McGregor, I.S.1    Issakidis, C.N.2    Prior, G.3
  • 62
    • 84872156419 scopus 로고    scopus 로고
    • The endocannabinoid system and the brain
    • Mechoulam R, Parker LA (2013) The endocannabinoid system and the brain. Annu Rev Psychol 64:21-47. doi: 10.1146/annurev-psych-113011-143739
    • (2013) Annu Rev Psychol , vol.64 , pp. 21-47
    • Mechoulam, R.1    Parker, L.A.2
  • 64
    • 84875230816 scopus 로고    scopus 로고
    • Endocannabinoid system and mood disorders: Priming a target for new therapies
    • Micale V, Di Marzo V, Sulcova A, Wotjak CT, Drago F (2013) Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacol Ther 138:18-37. doi: 10.1016/j.pharmthera.2012.12.002
    • (2013) Pharmacol Ther , vol.138 , pp. 18-37
    • Micale, V.1    Di Marzo, V.2    Sulcova, A.3    Wotjak, C.T.4    Drago, F.5
  • 65
    • 33746913292 scopus 로고    scopus 로고
    • The endocannabinoid system controls a key epileptogenic circuit in the hippocampus
    • Monory K, Massa F, Egertová M, Eder M, Kelsch W, Blaudzun H, Westenbroek R, Kelsch W, Jacob W, Marsch R, Ekker M, Long J, Rubenstein J, Goebbels S, Nave KA, During M, Klugmann M, Wölfel B, Dodt HU, Zieglgänsberger W, Wotjak CT, Mackie K, Elphick MR, Marsicano G, Lutz B (2006) The endocannabinoid system controls a key epileptogenic circuit in the hippocampus. Neuron 51:455-466
    • (2006) Neuron , vol.51 , pp. 455-466
    • Monory K, M.1
  • 67
    • 84857133914 scopus 로고    scopus 로고
    • Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety - Two sides of one coin?
    • Moreira FA, Aguiar DC, Terzian AL, Guimarães FS, Wotjak CT (2012) Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety - two sides of one coin? Neuroscience 204:186-192. doi: 10.1016/j.neuroscience.2011.08.046
    • (2012) Neuroscience , vol.204 , pp. 186-192
    • Moreira, F.A.1    Aguiar, D.C.2    Terzian, A.L.3    Guimarães, F.S.4    Wotjak, C.T.5
  • 68
    • 84919905510 scopus 로고    scopus 로고
    • Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training
    • 1:CAS:528:DC%2BC2cXitVClu7jJ 4280626 25489086
    • Morena M, Roozendaal B, Trezza V, Ratano P, Peloso A, Hauer D et al (2014) Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. Proc Natl Acad Sci U S A 111:18333-18338
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 18333-18338
    • Morena, M.1    Roozendaal, B.2    Trezza, V.3    Ratano, P.4    Peloso, A.5    Hauer, D.6
  • 70
    • 34548094300 scopus 로고    scopus 로고
    • Exposure to marijuana smoke impairs memory retrieval in mice
    • Niyuhire F, Varvel SA, Martin BR, Lichtman AH (2007) Exposure to marijuana smoke impairs memory retrieval in mice. J Pharmacol Exp Ther 322:1067-1075. doi: 10.1124/jpet.107.119594
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 1067-1075
    • Niyuhire, F.1    Varvel, S.A.2    Martin, B.R.3    Lichtman, A.H.4
  • 71
    • 34248530643 scopus 로고    scopus 로고
    • The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats
    • Pamplona FA, Prediger RD, Pandolfo P, Takahashi RN (2006) The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats. Psychopharmacology (Berl) 188:641-649. doi: 10.1007/s00213-006-0514-0
    • (2006) Psychopharmacology (Berl) , vol.188 , pp. 641-649
    • Pamplona, F.A.1    Prediger, R.D.2    Pandolfo, P.3    Takahashi, R.N.4
  • 72
    • 44649136682 scopus 로고    scopus 로고
    • Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats
    • Pamplona FA, Bitencourt RM, Takahashi RN (2008) Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats. Neurobiol Learn Mem 90:290-293. doi: 10.1016/j.nlm.2008.04.003
    • (2008) Neurobiol Learn Mem , vol.90 , pp. 290-293
    • Pamplona, F.A.1    Bitencourt, R.M.2    Takahashi, R.N.3
  • 73
    • 80053024234 scopus 로고    scopus 로고
    • Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice
    • Pan B, Wang W, Zhong P, Blankman JL, Cravatt BF, Liu QS (2011) Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. J Neurosci 31:13420-13430. doi: 10.1523/JNEUROSCI. 2075-11.2011
    • (2011) J Neurosci , vol.31 , pp. 13420-13430
    • Pan, B.1    Wang, W.2    Zhong, P.3    Blankman, J.L.4    Cravatt, B.F.5    Liu, Q.S.6
  • 74
    • 84874453519 scopus 로고    scopus 로고
    • Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury
    • Pardini M, Krueger F, Koenigs M, Raymont V, Hodgkinson C, Zoubak S et al (2012) Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury. Transl Psychiatry 2:e75. doi: 10.1038/tp.2012.1
    • (2012) Transl Psychiatry , vol.2 , pp. e75
    • Pardini, M.1    Krueger, F.2    Koenigs, M.3    Raymont, V.4    Hodgkinson, C.5    Zoubak, S.6
  • 75
    • 84873851437 scopus 로고    scopus 로고
    • Implications of memory modulation for post-traumatic stress and fear disorders
    • Parsons RG, Ressler KJ (2013) Implications of memory modulation for post-traumatic stress and fear disorders. Nat Neurosci 16:146-153. doi: 10.1038/nn.3296
    • (2013) Nat Neurosci , vol.16 , pp. 146-153
    • Parsons, R.G.1    Ressler, K.J.2
  • 76
    • 16244398653 scopus 로고    scopus 로고
    • Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling
    • Patel S, Roelke CT, Rademacher DJ, Hillard CJ (2005) Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling. Eur J Neurosci 21:1057-1069. doi: 10.1111/j.1460-9568.2005.03916.x
    • (2005) Eur J Neurosci , vol.21 , pp. 1057-1069
    • Patel, S.1    Roelke, C.T.2    Rademacher, D.J.3    Hillard, C.J.4
  • 77
    • 77950600766 scopus 로고    scopus 로고
    • Dissociation of within- and between-session extinction of conditioned fear
    • Plendl W, Wotjak CT (2010) Dissociation of within- and between-session extinction of conditioned fear. J Neurosci 30:4990-4998. doi: 10.1523/JNEUROSCI. 6038-09.2010
    • (2010) J Neurosci , vol.30 , pp. 4990-4998
    • Plendl, W.1    Wotjak, C.T.2
  • 78
    • 0035958637 scopus 로고    scopus 로고
    • Cannabinoid activation of recombinant and endogenous vanilloid receptors
    • 1:CAS:528:DC%2BD3MXlslGmtrw%3D 11672565
    • Ralevic V, Kendall DA, Jerman JC, Middlemiss DN, Smart D (2001) Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur J Pharmacol 424:211-219
    • (2001) Eur J Pharmacol , vol.424 , pp. 211-219
    • Ralevic, V.1    Kendall, D.A.2    Jerman, J.C.3    Middlemiss, D.N.4    Smart, D.5
  • 79
    • 84893368679 scopus 로고    scopus 로고
    • Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state
    • 24494683
    • Rea K, Ford GK, Olango WM, Harhen B, Roche M, Finn DP (2014) Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state. Eur J Neurosci 39:435-443
    • (2014) Eur J Neurosci , vol.39 , pp. 435-443
    • Rea, K.1    Ford, G.K.2    Olango, W.M.3    Harhen, B.4    Roche, M.5    Finn, D.P.6
  • 80
    • 84867583020 scopus 로고    scopus 로고
    • Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission
    • Rey AA, Purrio M, Viveros MP, Lutz B (2012) Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission. Neuropsychopharmacology 37:2624-2634. doi: 10.1038/npp.2012.123
    • (2012) Neuropsychopharmacology , vol.37 , pp. 2624-2634
    • Rey, A.A.1    Purrio, M.2    Viveros, M.P.3    Lutz, B.4
  • 81
    • 84857133825 scopus 로고    scopus 로고
    • Fear relief - Toward a new conceptual frame work and what endocannabinoids gotta do with it
    • Riebe CJ, Pamplona FA, Pamplona F, Kamprath K, Wotjak CT (2012) Fear relief - toward a new conceptual frame work and what endocannabinoids gotta do with it. Neuroscience 204:159-185. doi: 10.1016/j.neuroscience.2011.11.057
    • (2012) Neuroscience , vol.204 , pp. 159-185
    • Riebe, C.J.1    Pamplona, F.A.2    Pamplona, F.3    Kamprath, K.4    Wotjak, C.T.5
  • 82
    • 0035116496 scopus 로고    scopus 로고
    • Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens
    • Ross RA, Gibson TM, Brockie HC, Leslie M, Pashmi G, Craib SJ et al (2001) Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br J Pharmacol 132:631-640. doi: 10.1038/sj.bjp.0703850
    • (2001) Br J Pharmacol , vol.132 , pp. 631-640
    • Ross, R.A.1    Gibson, T.M.2    Brockie, H.C.3    Leslie, M.4    Pashmi, G.5    Craib, S.J.6
  • 83
    • 84855359304 scopus 로고    scopus 로고
    • The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors
    • Savinainen JR, Saario SM, Laitinen JT (2012) The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors. Acta Physiol (Oxf) 204:267-276. doi: 10.1111/j.1748-1716.2011.02280.x
    • (2012) Acta Physiol (Oxf) , vol.204 , pp. 267-276
    • Savinainen, J.R.1    Saario, S.M.2    Laitinen, J.T.3
  • 84
    • 77956181836 scopus 로고    scopus 로고
    • Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
    • Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG et al (2010) Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat Neurosci 13:1113-1119. doi: 10.1038/nn.2616
    • (2010) Nat Neurosci , vol.13 , pp. 1113-1119
    • Schlosburg, J.E.1    Blankman, J.L.2    Long, J.Z.3    Nomura, D.K.4    Pan, B.5    Kinsey, S.G.6
  • 85
    • 79959977058 scopus 로고    scopus 로고
    • Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats
    • Sciolino NR, Zhou W, Hohmann AG (2011) Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. Pharmacol Res 64:226-234. doi: 10.1016/j.phrs.2011.04.010
    • (2011) Pharmacol Res , vol.64 , pp. 226-234
    • Sciolino, N.R.1    Zhou, W.2    Hohmann, A.G.3
  • 86
    • 34247871449 scopus 로고    scopus 로고
    • A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear
    • Siegmund A, Wotjak CT (2007) A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear. J Psychiatr Res 41:848-860. doi: 10.1016/j.jpsychires.2006.07.017
    • (2007) J Psychiatr Res , vol.41 , pp. 848-860
    • Siegmund, A.1    Wotjak, C.T.2
  • 87
    • 11444261071 scopus 로고    scopus 로고
    • Differences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of alpha-synuclein
    • Siegmund A, Langnaese K, Wotjak CT (2005) Differences in extinction of conditioned fear in C57BL/6 substrains are unrelated to expression of alpha-synuclein. Behav Brain Res 157:291-298. doi: 10.1016/j.bbr.2004.07.007
    • (2005) Behav Brain Res , vol.157 , pp. 291-298
    • Siegmund, A.1    Langnaese, K.2    Wotjak, C.T.3
  • 88
    • 80052273507 scopus 로고    scopus 로고
    • Distribution of diacylglycerol lipase alpha, an endocannabinoid synthesizing enzyme, in the rat forebrain
    • Suárez J, Ortíz O, Puente N, Bermúdez-Silva FJ, Blanco E, Fernández-Llebrez P et al (2011) Distribution of diacylglycerol lipase alpha, an endocannabinoid synthesizing enzyme, in the rat forebrain. Neuroscience 192:112-131. doi: 10.1016/j.neuroscience.2011.06.062
    • (2011) Neuroscience , vol.192 , pp. 112-131
    • Suárez, J.1    Ortíz, O.2    Puente, N.3    Bermúdez-Silva, F.J.4    Blanco, E.5    Fernández-Llebrez, P.6
  • 89
    • 84857397976 scopus 로고    scopus 로고
    • Cannabinoid-related agents in the treatment of anxiety disorders: Current knowledge and future perspectives
    • 1:CAS:528:DC%2BC38XktFSqt78%3D 3691841 22280339
    • Tambaro S, Bortolato M (2012) Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives. Recent Pat CNS Drug Discov 7:25-40
    • (2012) Recent Pat CNS Drug Discov , vol.7 , pp. 25-40
    • Tambaro, S.1    Bortolato, M.2
  • 90
    • 75949116246 scopus 로고    scopus 로고
    • The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission
    • Tanimura A, Yamazaki M, Hashimotodani Y, Uchigashima M, Kawata S, Abe M et al (2010) The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron 65:320-327. doi: 10.1016/j.neuron.2010.01.021
    • (2010) Neuron , vol.65 , pp. 320-327
    • Tanimura, A.1    Yamazaki, M.2    Hashimotodani, Y.3    Uchigashima, M.4    Kawata, S.5    Abe, M.6
  • 91
    • 84880622031 scopus 로고    scopus 로고
    • The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder (PTSD)
    • Trezza V, Campolongo P (2013) The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder (PTSD). Front Behav Neurosci 7:100. doi: 10.3389/fnbeh.2013.00100
    • (2013) Front Behav Neurosci , vol.7 , pp. 100
    • Trezza, V.1    Campolongo, P.2
  • 92
    • 79957649283 scopus 로고    scopus 로고
    • Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus
    • Uchigashima M, Yamazaki M, Yamasaki M, Tanimura A, Sakimura K, Kano M et al (2011) Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. J Neurosci 31:7700-7714. doi: 10.1523/JNEUROSCI. 5665-10.2011
    • (2011) J Neurosci , vol.31 , pp. 7700-7714
    • Uchigashima, M.1    Yamazaki, M.2    Yamasaki, M.3    Tanimura, A.4    Sakimura, K.5    Kano, M.6
  • 93
    • 84862092052 scopus 로고    scopus 로고
    • Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: An in vivo microdialysis study
    • Wiskerke J, Irimia C, Cravatt BF, De Vries TJ, Schoffelmeer AN, Pattij T et al (2012) Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem Neurosci 3:407-417. doi: 10.1021/cn300036b
    • (2012) ACS Chem Neurosci , vol.3 , pp. 407-417
    • Wiskerke, J.1    Irimia, C.2    Cravatt, B.F.3    De Vries, T.J.4    Schoffelmeer, A.N.5    Pattij, T.6
  • 94
    • 33646932964 scopus 로고    scopus 로고
    • Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor
    • Yoshida T, Fukaya M, Uchigashima M, Miura E, Kamiya H, Kano M et al (2006) Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. J Neurosci 26:4740-4751. doi: 10.1523/JNEUROSCI. 0054-06.2006
    • (2006) J Neurosci , vol.26 , pp. 4740-4751
    • Yoshida, T.1    Fukaya, M.2    Uchigashima, M.3    Miura, E.4    Kamiya, H.5    Kano, M.6
  • 95
    • 80054101176 scopus 로고    scopus 로고
    • Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex
    • Yoshino H, Miyamae T, Hansen G, Zambrowicz B, Flynn M, Pedicord D et al (2011) Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. J Physiol 589:4857-4884. doi: 10.1113/jphysiol.2011.212225
    • (2011) J Physiol , vol.589 , pp. 4857-4884
    • Yoshino, H.1    Miyamae, T.2    Hansen, G.3    Zambrowicz, B.4    Flynn, M.5    Pedicord, D.6
  • 96
    • 0034640192 scopus 로고    scopus 로고
    • The anandamide transport inhibitor AM404 activates vanilloid receptors
    • 1:CAS:528:DC%2BD3cXjsVGnt78%3D 10822052
    • Zygmunt PM, Chuang H, Movahed P, Julius D, Högestätt ED (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur J Pharmacol 396:39-42
    • (2000) Eur J Pharmacol , vol.396 , pp. 39-42
    • Zygmunt, P.M.1    Chuang, H.2    Movahed, P.3    Julius, D.4    Högestätt, E.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.