In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice

Translational Psychiatry

Volumn 2, Issue , 2012, Pages

  Heldt, S A ^a   Mou, L ^b   Ressler, K J ^b,c  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

amygdale; extinction; fear; GABA; GAD67; lentivirus

Indexed keywords

4 AMINOBUTYRIC ACID; DIAZEPAM; GLUTAMATE DECARBOXYLASE 67; SMALL INTERFERING RNA; ANXIOLYTIC AGENT; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 1;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; GENE SILENCING; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; LOCOMOTION; MALE; MAZE TEST; MOUSE; NEUROTRANSMISSION; NONHUMAN; PROTEIN ANALYSIS; TRANQUILIZING ACTIVITY; WESTERN BLOTTING; ANIMAL; ANIMAL BEHAVIOR; ANXIETY; C57BL MOUSE; CATALEPSY; CONDITIONING; FEAR; GENETICS; METABOLISM; PHYSIOLOGY; REINFORCEMENT; RNA INTERFERENCE;

AMYGDALA; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BEHAVIOR, ANIMAL; CONDITIONING (PSYCHOLOGY); DIAZEPAM; EXTINCTION, PSYCHOLOGICAL; FEAR; FREEZING REACTION, CATALEPTIC; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; LENTIVIRUS; MALE; MICE; MICE, INBRED C57BL; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84869751850     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2012.101     Document Type: Article

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