Consequences of extinction training on associative and non-associative fear in a mouse model of Posttraumatic Stress Disorder (PTSD)

Behavioural Brain Research

Volumn 205, Issue 2, 2009, Pages 544-549

  Golub, Yulia ^a,b   Mauch, Christoph P ^a   Dahlhoff, Maik ^c   Wotjak, Carsten T ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Associative fear; Context; Exposure therapy; Extinction; Hyperarousal; PTSD; Sensitization; Startle

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; AROUSAL; ARTICLE; COGNITIVE THERAPY; CONTROLLED STUDY; FEAR; FOOTSHOCK; MALE; MOUSE; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; REINFORCEMENT; THERAPY EFFECT;

ANALYSIS OF VARIANCE; ANIMALS; AROUSAL; ASSOCIATION LEARNING; COGNITIVE THERAPY; CONDITIONING, CLASSICAL; DISEASE MODELS, ANIMAL; ELECTROSHOCK; EXTINCTION, PSYCHOLOGICAL; FEAR; MALE; MICE; MICE, INBRED C57BL; RANDOM ALLOCATION; STRESS DISORDERS, POST-TRAUMATIC; TIME FACTORS;

EID: 70349782163     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2009.08.019     Document Type: Article

References (31)

1. Antelman S.M. Time-dependent sensitization as the cornerstone for a new approach to pharmacotherapy-drugs as foreign stressful stimuli. Drug Dev Res 14 (1988) 1-30
2. Baddeley A.D. Selective attention and performance in dangerous environments. Br J Psychol 63 (1972) 537-546
3. Balogh S.A., Radcliffe R.A., Logue S.F., and Wehner J.M. Contextual and cued fear conditioning in C57BL/6J and DBA/2J mice: context discrimination and the effects of retention interval. Behav Neurosci 116 (2002) 947-957
4. Briere J., Scott C., and Weathers F. Peritraumatic and persistent dissociation in the presumed etiology of PTSD. Am J Psychiatry 162 (2005) 2295-2301
5. Campfield K.M., and Hills A.M. Effect of timing of critical incident stress debriefing (CISD) on posttraumatic symptoms. J Trauma Stress 14 (2001) 327-340
6. Chang C.H., and Maren S. Early extinction after fear conditioning yields a context-independent and short-term suppression of conditional freezing in rats. Learn Mem 16 (2009) 62-68
7. Charney D.S., Deutch A.Y., Krystal J.H., Southwick S.M., and Davis M. Psychobiologic mechanisms of posttraumatic-stress-disorder. Arch Gen Psychiatry 50 (1993) 294-306
8. Cohen H., Zohar J., Matar M.A., Zeev K., Loewenthal U., and Richter-Levin G. Setting apart the affected: the use of behavioral criteria in animal models of post traumatic stress disorder. Neuropsychopharmacology 29 (2004) 1962-1970
9. Ehlers A., Hackmann A., and Michael T. Intrusive re-experiencing in post-traumatic stress disorder: phenomenology, theory, and therapy. Memory 12 (2004) 403-415
10. Eysenck H.J. A theory of the incubation of anxiety-fear responses. Behav Res Ther 6 (1968) 309-321
11. Foa E.B. Psychosocial treatment of posttraumatic stress disorder. J Clin Psychiatry 61 Suppl. 5 (2000) 43-48
12. Foa E.B., Zinbarg R., and Rothbaum B.O. Uncontrollability and unpredictability in post-traumatic stress disorder: an animal model. Psychol Bull 112 (1992) 218-238
13. Frankland P.W., and Bontempi B. The organization of recent and remote memories. Nat Rev Neurosci 6 (2005) 119-130
14. Grillon C., Morgan C.A., Southwick S.M., Davis M., and Charney D.S. Baseline startle amplitude and prepulse inhibition in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res 64 (1996) 169-178
15. Huang C.C., Liang Y.C., and Hsu K.S. Characterization of the mechanism underlying the reversal of long term potentiation by low frequency stimulation at hippocampal CA1 synapses. J Biol Chem 276 (2001) 48108-48117
16. Kamprath K., and Wotjak C.T. Nonassociative learning processes determine expression and extinction of conditioned fear in mice. Learn Mem 11 (2004) 770-786
17. Layton B., and Krikorian R. Memory mechanisms in posttraumatic stress disorder. J Neuropsychiatry Clin Neurosci 14 (2002) 254-261
18. Lin C.H., Lee C.C., and Gean P.W. Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory. Mol Pharmacol 63 (2003) 44-52
19. Maren S., and Chang C.H. Recent fear is resistant to extinction. Proc Natl Acad Sci USA 103 (2006) 18020-18025
20. Myers K.M., and Davis M. Behavioral and neural analysis of extinction. Neuron 36 (2002) 567-584
21. Myers K.M., Ressler K.J., and Davis M. Different mechanisms of fear extinction dependent on length of time since fear acquisition. Learn Mem 13 (2006) 216-223
22. Pole N., Gone J.P., and Kulkarni M. Posttraumatic stress disorder among ethnoracial minorities in the United States. Clin Psychol Sci Pract 15 (2008) 35-61
23. Radulovic J., Kammermeier J., and Spiess J. Generalization of fear responses in C57BL/6N mice subjected to one-trial foreground contextual fear conditioning. Behav Brain Res 95 (1998) 179-189
24. Sacchetti B., Lorenzini C.A., Baldi E., Tassoni G., and Bucherelli C. Auditory thalamus, dorsal hippocampus, basolateral amygdala, and perirhinal cortex role in the consolidation of conditioned freezing to context and to acoustic conditioned stimulus in the rat. J Neurosci 19 (1999) 9570-9578
25. Shalev A.Y., Peri T., Brandes D., Freedman S., Orr S.P., and Pitman R.K. Auditory startle response in trauma survivors with posttraumatic stress disorder: a prospective study. Am J Psychiatry 157 (2000) 255-261
26. Siegmund A., and Wotjak C.T. Toward an animal model of posttraumatic stress disorder. Ann NY Acad Sci 1071 (2006) 324-334
27. Siegmund A., and Wotjak C.T. A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear. J Psychiatry Res 41 (2007) 848-860
28. Siegmund A., and Wotjak C.T. Hyperarousal does not depend on trauma-related contextual memory in an animal model of Posttraumatic Stress Disorder. Physiol Behav 90 (2007) 103-107
29. Stiedl O., Palve M., Radulovic J., Birkenfeld K., and Spiess J. Differential impairment of auditory and contextual fear conditioning by protein synthesis inhibition in C57BL/6N mice. Behav Neurosci 113 (1999) 496-506
30. Wiltgen B.J., and Silva A.J. Memory for context becomes less specific with time. Learn Mem 14 (2007) 313-317
31. Yehuda R., and LeDoux J. Response variation following trauma: a translational neuroscience approach to understanding PTSD. Neuron 56 (2007) 19-32