Methyl CpG binding protein 2 gene disruption augments tonic currents of γ-aminobutyric acid receptors in locus coeruleus neurons: Impact on neuronal excitability and breathing

Journal of Biological Chemistry

Volumn 290, Issue 30, 2015, Pages 18400-18411

  Zhong, Weiwei ^a   Cui, Ningren ^a   Jin, Xin ^a   Oginsky, Max F ^a   Wu, Yang ^a   Zhang, Shuang ^a   Bondy, Brian ^a   Johnson, Christopher M ^a   Jiang, Chun ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; MAMMALS;

EXPRESSION LEVELS; GAMMA-AMINOBUTYRIC ACIDS; GENE DISRUPTIONS; MEMBRANE PROPERTIES; METHYL-CPG-BINDING; MOUSE MODELS; PCR ANALYSIS; RETT SYNDROME;

NEURONS;

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; 4,5,6,7 TETRAHYDROISOXAZOLO[4,5 C]PYRIDIN 3 OL; BICUCULLINE; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; GABOXADOL; ISOXAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APNEA; ARTICLE; BREATHING DISORDER; BREATHING RATE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HYPERPOLARIZATION; LOCUS CERULEUS; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SYNAPTIC TRANSMISSION; ANIMAL; BIOSYNTHESIS; BREATHING; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RETT SYNDROME; SINGLE CELL ANALYSIS; SYNAPSE; TRANSGENIC MOUSE;

MUS;

ANIMALS; BICUCULLINE; GABA AGONISTS; GABAERGIC NEURONS; HUMANS; ISOXAZOLES; LOCUS COERULEUS; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, TRANSGENIC; RECEPTORS, GABA; RECEPTORS, GABA-A; RESPIRATION; RETT SYNDROME; SINGLE-CELL ANALYSIS; SYNAPSES;

EID: 84937692368     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.650465     Document Type: Article

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