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Volumn 39, Issue 2, 2009, Pages 223-230

GABAA receptor downregulation in brains of subjects with autism

Author keywords

Autism; Brain; GABRA1; GABRA2; GABRA3; GABRB3

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR A1; 4 AMINOBUTYRIC ACID RECEPTOR A2; 4 AMINOBUTYRIC ACID RECEPTOR A3; 4 AMINOBUTYRIC ACID RECEPTOR B3; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

EID: 58549113548     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-008-0646-7     Document Type: Article
Times cited : (352)

References (50)
  • 3
  • 4
    • 0000248735 scopus 로고
    • Neuroanatomic observations of the brain in autism
    • Bauman, M. L., & Kemper, T. L. (Eds.). Baltimore, MD: Johns Hopkins University Press
    • Bauman, M. L., & Kemper, T. L. (Eds.). (1994). Neuroanatomic observations of the brain in autism. In The neurobiology of autism (pp. 19-145). Baltimore, MD: Johns Hopkins University Press.
    • (1994) In the Neurobiology of Autism , pp. 19-145
  • 5
    • 33748957843 scopus 로고    scopus 로고
    • Structural brain anatomy in autism: What is the evidence?
    • Bauman, M. L., & Kemper, T. L. (Eds.). Baltimore, MD: Johns Hopkins University Press
    • Bauman, M. L., & Kemper, T. L. (Eds.). (2005). Structural brain anatomy in autism: What is the evidence? In The neurobiology of autism (pp. 121-135). Baltimore, MD: Johns Hopkins University Press.
    • (2005) In the Neurobiology of Autism , pp. 121-135
  • 6
    • 0027297673 scopus 로고
    • Significance and management of transitory cognitive impairment due to subclinical EEG discharges in children
    • Binnie, C. D. (1993). Significance and management of transitory cognitive impairment due to subclinical EEG discharges in children. Brain and Development, 15, 23-30.
    • (1993) Brain and Development , vol.15 , pp. 23-30
    • Binnie, C.D.1
  • 11
    • 11844251366 scopus 로고    scopus 로고
    • Localized enlargement of the frontal lobe in autism
    • 10.1016/j.biopsych.2004.11.005
    • R Carper E Courchesne 2005 Localized enlargement of the frontal lobe in autism Biological Psychiatry 57 126 133 10.1016/j.biopsych.2004.11.005
    • (2005) Biological Psychiatry , vol.57 , pp. 126-133
    • Carper, R.1    Courchesne, E.2
  • 12
    • 0036677965 scopus 로고    scopus 로고
    • Cerebral lobes in autism: Early hyperplasia and abnormal age effects
    • 10.1006/nimg.2002.1099
    • RA Carper P Moses ZD Tigue E Courchesne 2002 Cerebral lobes in autism: Early hyperplasia and abnormal age effects NeuroImage 16 1038 1051 10.1006/nimg.2002.1099
    • (2002) NeuroImage , vol.16 , pp. 1038-1051
    • Carper, R.A.1    Moses, P.2    Tigue, Z.D.3    Courchesne, E.4
  • 13
    • 0037412007 scopus 로고    scopus 로고
    • Clinical and macroscopic correlates of minicolumnar pathology in autism
    • Casanova, M. F., Buxhoeveden, D. P., & Brown, C. (2002). Clinical and macroscopic correlates of minicolumnar pathology in autism. Journal of Child Neurology, 17, 692-695.
    • (2002) Journal of Child Neurology , vol.17 , pp. 692-695
    • Casanova, M.F.1    Buxhoeveden, D.P.2    Brown, C.3
  • 14
    • 20544457861 scopus 로고    scopus 로고
    • Why the frontal cortex in autism might be talking only to itself: Local over-connectivity but long-distance disconnection
    • 10.1016/j.conb.2005.03.001
    • E Courchesne K Pierce 2005 Why the frontal cortex in autism might be talking only to itself: Local over-connectivity but long-distance disconnection Current Opinion in Neurobiology 15 225 230 10.1016/j.conb.2005.03.001
    • (2005) Current Opinion in Neurobiology , vol.15 , pp. 225-230
    • Courchesne, E.1    Pierce, K.2
  • 17
    • 38049013294 scopus 로고    scopus 로고
    • Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: A potential model of autism spectrum disorder
    • 10.1016/j.bbr.2007.09.009
    • TM DeLorey P Sahbaie E Hashemi GE Homanics JD Clark 2008 Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: A potential model of autism spectrum disorder Behavioural Brain Research 187 207 220 10.1016/j.bbr.2007.09.009
    • (2008) Behavioural Brain Research , vol.187 , pp. 207-220
    • Delorey, T.M.1    Sahbaie, P.2    Hashemi, E.3    Homanics, G.E.4    Clark, J.D.5
  • 18
  • 22
    • 0037108019 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in parietal and cerebellar cortices of autistic subjects
    • 10.1016/S0006-3223(02)01430-0
    • SH Fatemi A Halt J Stary R Kanodia SC Schulz G Realmuto 2002 Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in parietal and cerebellar cortices of autistic subjects Biological Psychiatry 52 805 810 10.1016/S0006-3223(02)01430-0
    • (2002) Biological Psychiatry , vol.52 , pp. 805-810
    • Fatemi, S.H.1    Halt, A.2    Stary, J.3    Kanodia, R.4    Schulz, S.C.5    Realmuto, G.6
  • 23
    • 9244249796 scopus 로고    scopus 로고
    • GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum
    • 10.1016/j.schres.2004.02.017
    • SH Fatemi JM Stary JA Earle M Araghi-Niknam E Eagan 2005 GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum Schizophrenia Research 72 109 122 10.1016/j.schres.2004.02.017
    • (2005) Schizophrenia Research , vol.72 , pp. 109-122
    • Fatemi, S.H.1    Stary, J.M.2    Earle, J.A.3    Araghi-Niknam, M.4    Eagan, E.5
  • 24
    • 33646757886 scopus 로고    scopus 로고
    • The human Reelin gene: Transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia
    • 10.1016/j.pharmthera.2005.01.007
    • DR Grayson Y Chen E Costa E Dong A Guidotti M Kundakovic 2006 The human Reelin gene: Transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia Pharmacology & Therapeutics 111 272 286 10.1016/j.pharmthera.2005.01.007
    • (2006) Pharmacology & Therapeutics , vol.111 , pp. 272-286
    • Grayson, D.R.1    Chen, Y.2    Costa, E.3    Dong, E.4    Guidotti, A.5    Kundakovic, M.6
  • 26
    • 0033759439 scopus 로고    scopus 로고
    • Decrease in Reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study
    • 10.1001/archpsyc.57.11.1061
    • A Guidotti J Auta JM Davis V Di-Giorgi-Gerevini Y Dwivedi DR Grayson 2000 Decrease in Reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study Archives of General Psychiatry 57 1061 1069 10.1001/archpsyc.57.11.1061
    • (2000) Archives of General Psychiatry , vol.57 , pp. 1061-1069
    • Guidotti, A.1    Auta, J.2    Davis, J.M.3    Di-Giorgi-Gerevini, V.4    Dwivedi, Y.5    Grayson, D.R.6
  • 27
    • 34249036179 scopus 로고    scopus 로고
    • [3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: A multiple concentration autoradiographic study
    • Guptill, J. T., Booker, A. B., Gibbs, T. T., Kemper, T. L., Bauman, M. L., & Blatt, G. J. (2007). [3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: A multiple concentration autoradiographic study. Journal of Autism and Developmental Disorder, 37, 911-920.
    • (2007) Journal of Autism and Developmental Disorder , vol.37 , pp. 911-920
    • Guptill, J.T.1    Booker, A.B.2    Gibbs, T.T.3    Kemper, T.L.4    Bauman, M.L.5    Blatt, G.J.6
  • 30
    • 34247170891 scopus 로고    scopus 로고
    • 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders
    • 10.1093/hmg/ddm014
    • A Hogart RP Nagarajan KA Patzel DH Yasui JM Lasalle 2007 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders Human Molecular Genetics 16 691 703 10.1093/hmg/ddm014
    • (2007) Human Molecular Genetics , vol.16 , pp. 691-703
    • Hogart, A.1    Nagarajan, R.P.2    Patzel, K.A.3    Yasui, D.H.4    Lasalle, J.M.5
  • 32
    • 40549109599 scopus 로고    scopus 로고
    • Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia
    • 10.1097/FPC.0b013e3282f70492
    • T Inada M Koga H Ishiguro Y Horiuchi A Syu T Yoshio 2008 Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia Pharmacogenetics and Genomics 18 317 323 10.1097/FPC.0b013e3282f70492
    • (2008) Pharmacogenetics and Genomics , vol.18 , pp. 317-323
    • Inada, T.1    Koga, M.2    Ishiguro, H.3    Horiuchi, Y.4    Syu, A.5    Yoshio, T.6
  • 34
    • 33847748974 scopus 로고    scopus 로고
    • Association of GABRB3 polymorphisms with autism spectrum disorders in Korean trios
    • 10.1159/000098651
    • SA Kim JH Kim M Park IH Cho HJ Yoo 2006 Association of GABRB3 polymorphisms with autism spectrum disorders in Korean trios Neuropsychobiology 54 160 165 10.1159/000098651
    • (2006) Neuropsychobiology , vol.54 , pp. 160-165
    • Kim, S.A.1    Kim, J.H.2    Park, M.3    Cho, I.H.4    Yoo, H.J.5
  • 37
    • 25144511541 scopus 로고    scopus 로고
    • Autism and Asperger's disorder: Are they movement disorders involving the cerebellum and/or basal ganglia?
    • 10.1016/j.brainresbull.2005.07.011
    • A Nayate JL Bradshaw NJ Rinehart 2005 Autism and Asperger's disorder: Are they movement disorders involving the cerebellum and/or basal ganglia? Brain Research Bulletin 67 327 334 10.1016/j.brainresbull.2005.07.011
    • (2005) Brain Research Bulletin , vol.67 , pp. 327-334
    • Nayate, A.1    Bradshaw, J.L.2    Rinehart, N.J.3
  • 38
    • 0032776814 scopus 로고    scopus 로고
    • Measurement of GABAergic parameters in the prefrontal cortex in schizophrenia: Focus on GABA content, GABA(A) receptor alpha-1 subunit messenger RNA and human GABA transporter-1 (HGAT-1) messenger RNA expression
    • 10.1016/S0306-4522(99)00189-X
    • T Ohnuma SJ Augood H Arai PJ McKenna PC Emson 1999 Measurement of GABAergic parameters in the prefrontal cortex in schizophrenia: Focus on GABA content, GABA(A) receptor alpha-1 subunit messenger RNA and human GABA transporter-1 (HGAT-1) messenger RNA expression Neuroscience 93 441 448 10.1016/S0306-4522(99)00189-X
    • (1999) Neuroscience , vol.93 , pp. 441-448
    • Ohnuma, T.1    Augood, S.J.2    Arai, H.3    McKenna, P.C.4    Emson, P.C.5
  • 39
    • 10344221119 scopus 로고    scopus 로고
    • Neuropathological findings in autism
    • 10.1093/brain/awh287
    • SJ Palmen H van Engeland PR Hof C Schmitz 2004 Neuropathological findings in autism Brain 127 2572 2583 10.1093/brain/awh287
    • (2004) Brain , vol.127 , pp. 2572-2583
    • Palmen, S.J.1    Van Engeland, H.2    Hof, P.R.3    Schmitz, C.4
  • 40
    • 33746314832 scopus 로고    scopus 로고
    • Searching for ways out of the autism maze: Genetic, epigenetic and environmental clues
    • 10.1016/j.tins.2006.05.010
    • AM Persico T Bourgeron 2006 Searching for ways out of the autism maze: Genetic, epigenetic and environmental clues Trends in Neurosciences 29 349 358 10.1016/j.tins.2006.05.010
    • (2006) Trends in Neurosciences , vol.29 , pp. 349-358
    • Persico, A.M.1    Bourgeron, T.2
  • 41
    • 0035856428 scopus 로고    scopus 로고
    • Postmortem brain abnormalities of the glutamate neurotransmitter system in autism
    • AE Purcell OH Jeon AW Zimmerman ME Blue J Pevsner 2001 Postmortem brain abnormalities of the glutamate neurotransmitter system in autism Neurology 57 1618 1628
    • (2001) Neurology , vol.57 , pp. 1618-1628
    • Purcell, A.E.1    Jeon, O.H.2    Zimmerman, A.W.3    Blue, M.E.4    Pevsner, J.5
  • 42
  • 43
    • 0032446976 scopus 로고    scopus 로고
    • Magnetic resonance imaging study of the brain in autism
    • 10.1111/j.1440-1819.1998.tb01040.x
    • O Saitoh E Courchesne 1998 Magnetic resonance imaging study of the brain in autism Psychiatry and Clinical Neurosciences 52 S219 S222 10.1111/j.1440-1819.1998.tb01040.x
    • (1998) Psychiatry and Clinical Neurosciences , vol.52
    • Saitoh, O.1    Courchesne, E.2
  • 44
    • 14044252235 scopus 로고    scopus 로고
    • Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3
    • 10.1093/hmg/ddi045
    • RC Samaco A Hogart JM LaSalle 2005 Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3 Human Molecular Genetics 14 483 492 10.1093/hmg/ddi045
    • (2005) Human Molecular Genetics , vol.14 , pp. 483-492
    • Samaco, R.C.1    Hogart, A.2    Lasalle, J.M.3
  • 47
    • 36448968588 scopus 로고    scopus 로고
    • No evidence for significant association between GABA receptor genes in chromosome
    • 10.1007/s10038-007-0207-5
    • M Tochigi C Kato S Koishi Y Kawakubo K Yamamoto H Matsumoto 2007 No evidence for significant association between GABA receptor genes in chromosome Journal of Human Genetics 52 985 989 10.1007/s10038-007-0207-5
    • (2007) Journal of Human Genetics , vol.52 , pp. 985-989
    • Tochigi, M.1    Kato, C.2    Koishi, S.3    Kawakubo, Y.4    Yamamoto, K.5    Matsumoto, H.6
  • 50
    • 34247631067 scopus 로고    scopus 로고
    • Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: Pathophysiological implications
    • 10.1007/s00401-006-0176-3
    • J Yip JJ Soghomonian GJ Blatt 2007 Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: Pathophysiological implications Acta Neuropathologica 113 559 568 10.1007/s00401-006-0176-3
    • (2007) Acta Neuropathologica , vol.113 , pp. 559-568
    • Yip, J.1    Soghomonian, J.J.2    Blatt, G.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.