Distribution Analyzer, a methodology for identifying and clustering outlier conditions from single-cell distributions, and its application to a Nanog reporter RNAi screen

BMC Bioinformatics

Volumn 16, Issue 1, 2015, Pages

  Gingold, Julian A ^a   Coakley, Ed S ^b   Su, Jie ^a,c   Lee, Dung Fang ^a   Lau, Zerlina ^a   Zhou, Hongwei ^a   Felsenfeld, Dan P ^a   Schaniel, Christoph ^a   Lemischka, Ihor R ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Fluorescence distribution; Genome scale screen analysis; Hellinger distance; High content screening methodology; Kolmogorov Smirnov distance; Nanog RNAi screen

Indexed keywords

ALKALINITY; CELLS; CHEMICAL ANALYSIS; CYTOLOGY; FLUORESCENCE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES; MAMMALS; NUCLEIC ACIDS; PHOSPHATASES; RNA; STATISTICS; STEM CELLS;

CONVENTIONAL APPROACH; EXPERIMENTAL CONDITIONS; HELLINGER DISTANCE; HIGH-CONTENT SCREENING; KOLMOGOROV-SMIRNOV; MOUSE EMBRYONIC STEM CELLS; RNAI SCREENS; UNDERLYING DISTRIBUTION;

PROBABILITY DISTRIBUTIONS;

HOMEODOMAIN PROTEIN; MEDIATOR COMPLEX; NANOG PROTEIN, MOUSE; RETINOIC ACID; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NANOG;

ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGY; CELL DIFFERENTIATION; CELL LINE; CLUSTER ANALYSIS; CYTOLOGY; DRUG EFFECTS; GENETICS; GENOME; METABOLISM; MOUSE; MOUSE EMBRYONIC STEM CELL; PROCEDURES; PROMOTER REGION; REPORTER GENE; RNA INTERFERENCE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; GENES, REPORTER; GENOME; HOMEODOMAIN PROTEINS; MEDIATOR COMPLEX; MICE; MOUSE EMBRYONIC STEM CELLS; NANOG HOMEOBOX PROTEIN; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRETINOIN;

EID: 84937690594     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/s12859-015-0636-7     Document Type: Article

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