-
1
-
-
80052490840
-
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells
-
Zhang, X. et al. FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nat. Cell. Biol. 13, 1092-1099 (2011).
-
(2011)
Nat. Cell. Biol.
, vol.13
, pp. 1092-1099
-
-
Zhang, X.1
-
2
-
-
33746773659
-
Dissecting self-renewal in stem cells with RNA interference
-
Ivanova, N. et al. Dissecting self-renewal in stem cells with RNA interference. Nature 442, 533-538 (2006).
-
(2006)
Nature
, vol.442
, pp. 533-538
-
-
Ivanova, N.1
-
3
-
-
79951711112
-
Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains
-
Jiang, H. et al. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell 144, 513-525 (2011).
-
(2011)
Cell
, vol.144
, pp. 513-525
-
-
Jiang, H.1
-
4
-
-
79954414897
-
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
-
Ang, Y.S. et al. Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell 145, 183-197 (2011).
-
(2011)
Cell
, vol.145
, pp. 183-197
-
-
Ang, Y.S.1
-
5
-
-
55949124844
-
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
-
Shen, X. et al. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol. Cell 32, 491-502 (2008).
-
(2008)
Mol. Cell
, vol.32
, pp. 491-502
-
-
Shen, X.1
-
6
-
-
73349095689
-
Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells
-
Schaniel, C. et al. Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells 27, 2979-2991 (2009).
-
(2009)
Stem Cells
, vol.27
, pp. 2979-2991
-
-
Schaniel, C.1
-
7
-
-
46149110511
-
An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity
-
Fazzio, T.G., Huff, J.T. & Panning, B. An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell 134, 162-174 (2008).
-
(2008)
Cell
, vol.134
, pp. 162-174
-
-
Fazzio, T.G.1
Huff, J.T.2
Panning, B.3
-
8
-
-
77953727663
-
Chromatin-remodeling components of the BAF complex facilitate reprogramming
-
Singhal, N. et al. Chromatin-remodeling components of the BAF complex facilitate reprogramming. Cell 141, 943-955 (2010).
-
(2010)
Cell
, vol.141
, pp. 943-955
-
-
Singhal, N.1
-
9
-
-
1242267927
-
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
-
Sato, N., Meijer, L., Skaltsounis, L., Greengard, P. & Brivanlou, A.H. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 10, 55-63 (2004).
-
(2004)
Nat. Med.
, vol.10
, pp. 55-63
-
-
Sato, N.1
Meijer, L.2
Skaltsounis, L.3
Greengard, P.4
Brivanlou, A.H.5
-
10
-
-
0024245022
-
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
-
Smith, A.G. et al. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336, 688-690 (1988).
-
(1988)
Nature
, vol.336
, pp. 688-690
-
-
Smith, A.G.1
-
11
-
-
0024205842
-
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
-
Williams, R.L. et al. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336, 684-687 (1988).
-
(1988)
Nature
, vol.336
, pp. 684-687
-
-
Williams, R.L.1
-
12
-
-
0344845415
-
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
-
Ying, Q.L., Nichols, J., Chambers, I. & Smith, A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115, 281-292 (2003).
-
(2003)
Cell
, vol.115
, pp. 281-292
-
-
Ying, Q.L.1
Nichols, J.2
Chambers, I.3
Smith, A.4
-
13
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
-
Chen, X. et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133, 1106-1117 (2008).
-
(2008)
Cell
, vol.133
, pp. 1106-1117
-
-
Chen, X.1
-
14
-
-
48449084118
-
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
-
Marson, A. et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 134, 521-533 (2008).
-
(2008)
Cell
, vol.134
, pp. 521-533
-
-
Marson, A.1
-
15
-
-
33645381936
-
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
-
Loh, Y.H. et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38, 431-440 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 431-440
-
-
Loh, Y.H.1
-
16
-
-
40749104852
-
An extended transcriptional network for pluripotency of embryonic stem cells
-
Kim, J., Chu, J., Shen, X., Wang, J. & Orkin, S.H. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132, 1049-1061 (2008).
-
(2008)
Cell
, vol.132
, pp. 1049-1061
-
-
Kim, J.1
Chu, J.2
Shen, X.3
Wang, J.4
Orkin, S.H.5
-
17
-
-
33751092246
-
A protein interaction network for pluripotency of embryonic stem cells
-
Wang, J. et al. A protein interaction network for pluripotency of embryonic stem cells. Nature 444, 364-368 (2006).
-
(2006)
Nature
, vol.444
, pp. 364-368
-
-
Wang, J.1
-
18
-
-
50849115172
-
Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET
-
Mathur, D. et al. Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET. Genome Biol. 9, R126 (2008).
-
(2008)
Genome Biol.
, vol.9
-
-
Mathur, D.1
-
19
-
-
77949881949
-
An expanded Oct4 interaction network: Implications for stem cell biology, development, and disease
-
Pardo, M. et al. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell 6, 382-395 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 382-395
-
-
Pardo, M.1
-
20
-
-
77949900026
-
An Oct4-centered protein interaction network in embryonic stem cells
-
van den Berg, D.L. et al. An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 6, 369-381 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 369-381
-
-
Van Den Berg, D.L.1
-
21
-
-
64349096829
-
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal
-
Hu, G. et al. A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev. 23, 837-848 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 837-848
-
-
Hu, G.1
-
22
-
-
65249180173
-
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency
-
Ho, L. et al. An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc. Natl. Acad. Sci. USA 106, 5181-5186 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 5181-5186
-
-
Ho, L.1
-
23
-
-
0038143611
-
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
-
Chambers, I. et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113, 643-655 (2003).
-
(2003)
Cell
, vol.113
, pp. 643-655
-
-
Chambers, I.1
-
24
-
-
0037806031
-
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
-
Mitsui, K. et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113, 631-642 (2003).
-
(2003)
Cell
, vol.113
, pp. 631-642
-
-
Mitsui, K.1
-
25
-
-
45449093213
-
Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells
-
Dejosez, M. et al. Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell 133, 1162-1174 (2008).
-
(2008)
Cell
, vol.133
, pp. 1162-1174
-
-
Dejosez, M.1
-
26
-
-
78149465975
-
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
-
Chia, N.Y. et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 468, 316-320 (2010).
-
(2010)
Nature
, vol.468
, pp. 316-320
-
-
Chia, N.Y.1
-
27
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
-
28
-
-
4644223259
-
Mechanisms of gene silencing by double-stranded RNA
-
Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. Nature 431, 343-349 (2004).
-
(2004)
Nature
, vol.431
, pp. 343-349
-
-
Meister, G.1
Tuschl, T.2
-
29
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp, T.R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002).
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
30
-
-
0033555703
-
RNAi and double-strand RNA
-
Sharp, P.A. RNAi and double-strand RNA. Genes Dev. 13, 139-141 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 139-141
-
-
Sharp, P.A.1
-
31
-
-
33646050344
-
Delivery of short hairpin RNAs - Triggers of gene silencing - Into mouse embryonic stem cells
-
Schaniel, C. et al. Delivery of short hairpin RNAs - triggers of gene silencing - into mouse embryonic stem cells. Nat. Methods 3, 397-400 (2006).
-
(2006)
Nat. Methods
, vol.3
, pp. 397-400
-
-
Schaniel, C.1
-
32
-
-
4644350944
-
Unlocking the potential of the human genome with RNA interference
-
Hannon, G.J. & Rossi, J.J. Unlocking the potential of the human genome with RNA interference. Nature 431, 371-378 (2004).
-
(2004)
Nature
, vol.431
, pp. 371-378
-
-
Hannon, G.J.1
Rossi, J.J.2
-
33
-
-
0037019339
-
RNA interference in adult mice
-
McCaffrey, A.P. et al. RNA interference in adult mice. Nature 418, 38-39 (2002).
-
(2002)
Nature
, vol.418
, pp. 38-39
-
-
McCaffrey, A.P.1
-
34
-
-
0036273940
-
Gene silencing using micro-RNA designed hairpins
-
McManus, M.T., Petersen, C.P., Haines, B.B., Chen, J. & Sharp, P.A. Gene silencing using micro-RNA designed hairpins. RNA 8, 842-850 (2002).
-
(2002)
RNA
, vol.8
, pp. 842-850
-
-
McManus, M.T.1
Petersen, C.P.2
Haines, B.B.3
Chen, J.4
Sharp, P.A.5
-
35
-
-
0037089589
-
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
-
Paddison, P.J., Caudy, A.A., Bernstein, E., Hannon, G.J. & Conklin, D.S. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 16, 948-958 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 948-958
-
-
Paddison, P.J.1
Caudy, A.A.2
Bernstein, E.3
Hannon, G.J.4
Conklin, D.S.5
-
36
-
-
0036251639
-
Effective expression of small interfering RNA in human cells
-
Paul, C.P., Good, P.D., Winer, I. & Engelke, D.R. Effective expression of small interfering RNA in human cells. Nat. Biotechnol. 20, 505-508 (2002).
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 505-508
-
-
Paul, C.P.1
Good, P.D.2
Winer, I.3
Engelke, D.R.4
-
37
-
-
0037117550
-
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
-
Sui, G. et al. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc. Natl. Acad. Sci. USA 99, 5515-5520 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 5515-5520
-
-
Sui, G.1
-
38
-
-
0036787671
-
siRNA-mediated gene silencing in vitro and in vivo
-
Xia, H., Mao, Q., Paulson, H.L. & Davidson, B.L. siRNA-mediated gene silencing in vitro and in vivo. Nat. Biotechnol. 20, 1006-1010 (2002).
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 1006-1010
-
-
Xia, H.1
Mao, Q.2
Paulson, H.L.3
Davidson, B.L.4
-
39
-
-
0037197914
-
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
-
Yu, J.Y., DeRuiter, S.L. & Turner, D.L. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc. Natl. Acad. Sci. USA 99, 6047-6052 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6047-6052
-
-
Yu, J.Y.1
DeRuiter, S.L.2
Turner, D.L.3
-
40
-
-
77955359846
-
Exploration of self-renewal and pluripotency in ES cells using RNAi
-
Schaniel, C., Lee, D.F. & Lemischka, I.R. Exploration of self-renewal and pluripotency in ES cells using RNAi. Methods Enzymol. 477, 351-365 (2010).
-
(2010)
Methods Enzymol.
, vol.477
, pp. 351-365
-
-
Schaniel, C.1
Lee, D.F.2
Lemischka, I.R.3
-
41
-
-
70450160004
-
Systems-level dynamic analyses of fate change in murine embryonic stem cells
-
Lu, R. et al. Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature 462, 358-362 (2009).
-
(2009)
Nature
, vol.462
, pp. 358-362
-
-
Lu, R.1
-
42
-
-
33646033137
-
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
-
Moffat, J. et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283-1298 (2006).
-
(2006)
Cell
, vol.124
, pp. 1283-1298
-
-
Moffat, J.1
-
43
-
-
69249223435
-
Stem cell pluripotency: A cellular trait that depends on transcription factors, chromatin state and a checkpoint deficient cell cycle
-
Boheler, K.R. Stem cell pluripotency: a cellular trait that depends on transcription factors, chromatin state and a checkpoint deficient cell cycle. J. Cell Physiol. 221, 10-17 (2009).
-
(2009)
J. Cell Physiol.
, vol.221
, pp. 10-17
-
-
Boheler, K.R.1
-
44
-
-
0028157458
-
Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts
-
Savatier, P., Huang, S., Szekely, L., Wiman, K.G. & Samarut, J. Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts. Oncogene 9, 809-818 (1994).
-
(1994)
Oncogene
, vol.9
, pp. 809-818
-
-
Savatier, P.1
Huang, S.2
Szekely, L.3
Wiman, K.G.4
Samarut, J.5
-
45
-
-
16644395172
-
Inducible transgene expression in mouse stem cells
-
Ting, D.T., Kyba, M. & Daley, G.Q. Inducible transgene expression in mouse stem cells. Methods Mol. Med. 105, 23-46 (2005).
-
(2005)
Methods Mol. Med.
, vol.105
, pp. 23-46
-
-
Ting, D.T.1
Kyba, M.2
Daley, G.Q.3
-
46
-
-
70349445264
-
Systems biology of stem cell fate and cellular reprogramming
-
Macarthur, B.D., Ma'ayan, A. & Lemischka, I.R. Systems biology of stem cell fate and cellular reprogramming. Nat. Rev. Mol. Cell Biol. 10, 672-681 (2009).
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 672-681
-
-
Macarthur, B.D.1
Ma'Ayan, A.2
Lemischka, I.R.3
-
47
-
-
0036727416
-
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
-
Lewis, D.L., Hagstrom, J.E., Loomis, A.G., Wolff, J.A. & Herweijer, H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat. Genet. 32, 107-108 (2002).
-
(2002)
Nat. Genet.
, vol.32
, pp. 107-108
-
-
Lewis, D.L.1
Hagstrom, J.E.2
Loomis, A.G.3
Wolff, J.A.4
Herweijer, H.5
-
48
-
-
0346258167
-
Mouse embryonic chimeras: Tools for studying mammalian development
-
Tam, P.P. & Rossant, J. Mouse embryonic chimeras: tools for studying mammalian development. Development 130, 6155-6163 (2003).
-
(2003)
Development
, vol.130
, pp. 6155-6163
-
-
Tam, P.P.1
Rossant, J.2
-
49
-
-
40349108452
-
Mouse embryo fibroblast (MEF) feeder cell preparation
-
chapter 23, Unit 23
-
Conner, D.A. Mouse embryo fibroblast (MEF) feeder cell preparation. Curr. Protoc. Mol. Biol. chapter 23, Unit 23 22 (2001).
-
(2001)
Curr. Protoc. Mol. Biol.
, pp. 22
-
-
Conner, D.A.1
-
50
-
-
77957243164
-
ChEA: Transcription factor regulation inferred from integrating genome-wide ChIP-X experiments
-
Lachmann, A. et al. ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments. Bioinformatics 26, 2438-2444 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 2438-2444
-
-
Lachmann, A.1
-
51
-
-
44949231424
-
Analyzing real-time PCR data by the comparative C(T) method
-
Schmittgen, T.D. & Livak, K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 3, 1101-1108 (2008).
-
(2008)
Nat. Protoc.
, vol.3
, pp. 1101-1108
-
-
Schmittgen, T.D.1
Livak, K.J.2
-
52
-
-
64749107970
-
Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors
-
Kutner, R.H., Zhang, X.Y. & Reiser, J. Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors. Nat. Protoc. 4, 495-505 (2009).
-
(2009)
Nat. Protoc.
, vol.4
, pp. 495-505
-
-
Kutner, R.H.1
Zhang, X.Y.2
Reiser, J.3
|