Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes

Circulation Research

Volumn 117, Issue 2, 2015, Pages 157-165

  Elgheznawy, Amro ^a   Shi, Lei ^a   Hu, Jiong ^a   Wittig, Ilka ^a   Laban, Hebatullah ^a   Pircher, Joachim ^b   Mann, Alexander ^c   Provost, Patrick ^d   Randriamboavonjy, Voahanginirina ^a   Fleming, Ingrid ^a  

^a GOETHE UNIVERSITY   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Endokrinologikum Frankfurt   (Germany)

^d LAVAL UNIVERSITY   (Canada)

Author keywords

diabetes mellitus; microRNA; platelets; signal transduction

Indexed keywords

ARGONAUTE 2 PROTEIN; BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 13A; CALPAIN; CALPAIN 1; CALPASTATIN; COLLAGEN; DICER; FIBRONECTIN; IONOMYCIN; MICRORNA; MICRORNA 142; MICRORNA 143; MICRORNA 155; MICRORNA 223; THROMBIN; UNCLASSIFIED DRUG; CALCIUM; CAPN1 PROTEIN, MOUSE; CYTOSKELETON PROTEIN; DEAD BOX PROTEIN; DICER1 PROTEIN, HUMAN; DICER1 PROTEIN, MOUSE; KINDLIN-3 PROTEIN, MOUSE; MEMBRANE PROTEIN; MICROSATELLITE DNA; MIG2B PROTEIN, HUMAN; PROTEOME; RIBONUCLEASE III; TUMOR PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOT RETRACTION; BLOOD CLOTTING; CAROTID ARTERY INJURY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC PATIENT; EMBOLISM; FEMALE; GENE DELETION; HUMAN; HUMAN CELL; MALE; MIDDLE AGED; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE RICH PLASMA; ANIMAL; BLOOD; C57BL MOUSE; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENETICS; KNOCKOUT MOUSE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY;

ADULT; ANIMALS; BLOOD PLATELETS; CALCIUM; CALPAIN; CYTOSKELETAL PROTEINS; DEAD-BOX RNA HELICASES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; FACTOR XIII; FEMALE; HUMANS; IONOMYCIN; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; MICROSATELLITE REPEATS; MIDDLE AGED; NEOPLASM PROTEINS; PLATELET AGGREGATION; PROTEOME; RIBONUCLEASE III;

EID: 84937682421     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.117.305784     Document Type: Article

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