Abrogation of DNA vector-based RNAi during apoptosis in mammalian cells due to caspase-mediated cleavage and inactivation of Dicer-1

Cell Death and Differentiation

Volumn 16, Issue 6, 2009, Pages 858-868

  Ghodgaonkar, M M ^a   Shah, R G ^a   Kandan Kulangara, F ^a   Affar, E B ^b   Qi, H H ^b   Wiemer, E ^c   Shah, G M ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b HARVARD MEDICAL SCHOOL   (United States)

^c JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DICER; DICER 1; LAMIN; MICRORNA; MICRORNA 16; MICRORNA 21; MICRORNA LET 7A; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA VECTOR; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME SPECIFICITY; GENE CONTROL; GENE INACTIVATION; GENE TARGETING; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REGULATORY MECHANISM; RNA CLEAVAGE; RNA INTERFERENCE;

AMINO ACID SEQUENCE; APOPTOSIS; CASPASE 3; CELL LINE; DEAD-BOX RNA HELICASES; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HELA CELLS; HUMANS; LAMIN TYPE A; MICRORNAS; POLY(ADP-RIBOSE) POLYMERASES; RIBONUCLEASE III; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA-INDUCED SILENCING COMPLEX; TUMOR SUPPRESSOR PROTEIN P14ARF;

MAMMALIA;

EID: 67349200238     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.15     Document Type: Article

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