A novel calpain inhibitor, ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3- di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-Methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 2, 2010, Pages 380-387

  Shimazawa, Masamitsu ^a   Suemori, Shinsuke ^a,b   Inokuchi, Yuta ^a   Matsunaga, Nozomu ^a   Nakajima, Yoshimi ^a   Oka, Takayuki ^c   Yamamoto, Tetsuya ^b   Hara, Hideaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c SENJU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

(1 [[( 1 BENZYL 3 CYCLOPROPYLAMINO 2,3 DI OXOPROPYL)AMINO)CARBONYL] 3 METHYLBUTYL]CARBAMIC ACID 5 METHOXY 3 OXAPENTYL ESTER; CALPASTATIN; DNA NUCLEOTIDYLEXOTRANSFERASE; FODRIN; N METHYL DEXTRO ASPARTIC ACID; PROTEIN P53; SNJ 1945; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL LOSS; CONTROLLED STUDY; DRUG ACTIVITY; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; REOXYGENATION; RETINA CELL; RETINA GANGLION CELL;

ADMINISTRATION, ORAL; ANIMALS; CALPAIN; CARBAMATES; CELL LINE; CELL SURVIVAL; GLYCOPROTEINS; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED STRAINS; N-METHYLASPARTATE; RETINA; RETINAL DEGENERATION; RETINAL GANGLION CELLS;

EID: 76749124869     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.156612     Document Type: Article

References (38)

1. Blomgren K, Zhu C, Wang X, Karlsson JO, Leverin AL, Bahr BA, Mallard C, and Hagberg H (2001) Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"? J Biol Chem 276:10191-10198.
2. Cheung ZH, Gong K, and Ip NY (2008) Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. J Neurosci 28:4872-4877.
3. Chiu K, Lam TT, Ying Li WW, Caprioli J, and Kwong Kwong JM (2005) Calpain and N-methyl-D-aspartate (NMDA)-induced excitotoxicity in rat retinas. Brain Res 1046:207-215.
4. Choi DW (1994) Calcium and excitotoxic neuronal injury. Ann N Y Acad Sci 747:162-171.
5. Croall DE and DeMartino GN (1991) Calcium-activated neutral protease (calpain) system: structure, function, and regulation. Physiol Rev 71:813-847.
6. 2+ influx. Brain Res 1084:146-157.
7. Dreyer EB (1998) A proposed role for excitotoxicity in glaucoma. J Glaucoma 7:62-67.
8. Dufty BM, Warner LR, Hou ST, Jiang SX, Gomez-Isla T, Leenhouts KM, Oxford JT, Feany MB, Masliah E, and Rohn TT (2007) Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation. Am J Pathol 170:1725-1738.
9. Evans JS and Turner MD (2007) Emerging functions of the calpain superfamily of cysteine proteases in neuroendocrine secretory pathways. J Neurochem 103:849-859.
10. Faddis BT, Hasbani MJ, and Goldberg MP (1997) Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro. J Neurosci 17:951-959.
11. Goll DE, Thompson VF, Li H, Wei W, and Cong J (2003) The calpain system. Physiol Rev 83:731-801.
12. Grynspan F, Griffin WR, Cataldo A, Katayama S, and Nixon RA (1997) Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. Brain Res 763:145-158.
13. 2+ exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion. J Neurosci Res 87:906-917.
14. Jeon CJ, Strettoi E, and Masland RH (1998) The major cell populations of the mouse retina. J Neurosci 18:8936-8946.
15. Jiang Y, Ahn EY, Ryu SH, Kim DK, Park JS, Yoon HJ, You S, Lee BJ, Lee DS, and Jung JH (2004) Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication. BMC Cancer 4:70.
16. Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin N, and DiFiglia M (2001) Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc Natl Acad Sci U S A 98:12784-12789.
17. Krishnamoorthy RR, Agarwal P, Prasanna G, Vopat K, Lambert W, Sheedlo HJ, Pang IH, Shade D, Wordinger RJ, Yorio T, et al. (2001) Characterization of a transformed rat retinal ganglion cell line. Brain Res Mol Brain Res 86:1-12.
18. Lam TT, Abler AS, Kwong JM, and Tso MO (1999) N-methyl-D-aspartate (NMDA) - induced apoptosis in rat retina. Invest Ophthalmol Vis Sci 40:2391-2397.
19. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, and Tsai LH (2000) Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405:360-364.
20. Li BS, Ma W, Jaffe H, Zheng Y, Takahashi S, Zhang L, Kulkarni AB, and Pant HC (2003) Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J Biol Chem 278:35702-35709.
21. Nakajima E, David LL, Bystrom C, Shearer TR, and Azuma M (2006) Calpain-specific proteolysis in primate retina: contribution of calpains in cell death. Invest Ophthalmol Vis Sci 47:5469-5475.
22. Nath R, Raser KJ, McGinnis K, Nadimpalli R, Stafford D, and Wang KK (1996a) Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis. Neuro-report 8:249-255.
23. Nath R, Raser KJ, Stafford D, Hajimohammadreza I, Posner A, Allen H, Talanian RV, Yuen P, Gilbertsen RB, and Wang KK (1996b) Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme- like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis. Biochem J 319:683-690.
24. Oka T, Nakajima T, Tamada Y, Shearer TR, and Azuma M (2007) Contribution of calpains to photoreceptor cell death in N-methyl-N-nitrosourea-treated rats. Exp Neurol 204:39-48.
25. Oka T, Tamada Y, Nakajima E, Shearer TR, and Azuma M (2006a) Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension. J Neurosci Res 83:1342-1351.
26. Oka T, Walkup RD, Tamada Y, Nakajima E, Tochigi A, Shearer TR, and Azuma M (2006b) Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3- cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester. Neuroscience 141:2139-2145.
27. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, and Tsai LH (1999) Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402:615-622.
28. Polster BM, Basañez G, Etxebarria A, Hardwick JM, and Nicholls DG (2005) Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria. J Biol Chem 280:6447-6454.
29. 2+ influx upregulate calpain and induce apoptosis in PC12 cells. Brain Res 852:326-334.
30. Ray SK, Shields DC, Saido TC, Matzelle DC, Wilford GG, Hogan EL, and Banik NL (1999) Calpain activity and translational expression increased in spinal cord injury. Brain Res 816:375-380.
31. Saido TC, Sorimachi H, and Suzuki K (1994) Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J 8:814-822.
32. Saito K, Elce JS, Hamos JE, and Nixon RA (1993) Widespread activation of calciumactivated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc Natl Acad Sci U S A 90:2628-2632.
33. Sakamoto YR, Nakajima TR, Fukiage CR, Sakai OR, Yoshida YR, Azuma MR, and Shearer TR (2000) Involvement of calpain isoforms in ischemia-reperfusion injury in rat retina. Curr Eye Res 21:571-580.
34. Shimazawa M, Ito Y, Inokuchi Y, and Hara H (2007) Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage. Invest Ophthalmol Vis Sci 48:3729-3736.
35. Shirasaki Y, Miyashita H, Yamaguchi M, Inoue J, and Nakamura M (2005) Exploration of orally available calpain inhibitors: peptidyl alpha-ketoamides containing an amphiphile at P3 site. Bioorg Med Chem 13:4473-4484.
36. Shirasaki Y, Yamaguchi M, and Miyashita H (2006) Retinal penetration of calpain inhibitors in rats after oral administration. J Ocul Pharmacol Ther 22:417-424.
37. Siman R, Noszek JC, and Kegerise C (1989) Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage. J Neurosci 9:1579-1590.
38. Tamada Y, Fukiage C, Daibo S, Yoshida Y, Azuma M, and Shearer TR (2002) Involvement of calpain in hypoxia-induced damage in rat retina in vitro. Comp Biochem Physiol B Biochem Mol Biol 131:221-225.