Physiological characterization of the human EndoC-βH1 β-cell line

Biochemical and Biophysical Research Communications

Volumn 464, Issue 1, 2015, Pages 13-19

  Gurgul Convey, Ewa ^a   Kaminski, Martin T ^a   Lenzen, Sigurd ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Diabetes; Glucose responsiveness; Human EndoC H1 cells; Insulin secretion

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 2 OXOISOCAPROIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; FORSKOLIN; GLIBENCLAMIDE; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; GLUTAMINE; ISOBUTYLMETHYLXANTHINE; LEUCINE; MANNOHEPTULOSE; VOLTAGE GATED CALCIUM CHANNEL; ALPHA-KETOISOCAPROIC ACID; CALCIUM CHANNEL; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; OXOACID; SLC2A1 PROTEIN, HUMAN; SLC2A2 PROTEIN, HUMAN;

ARTICLE; CELL CLONE; CELL STRUCTURE; CONTROLLED STUDY; EC50; ENDOC BETAH1 BETA CELL LINE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; INSULIN RELEASE; PANCREAS ISLET BETA CELL; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; CYTOLOGY; FOUNDER EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

RATTUS;

1-METHYL-3-ISOBUTYLXANTHINE; 3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BIOLOGICAL TRANSPORT; CALCIUM CHANNELS; CELL LINE; COLFORSIN; FOUNDER EFFECT; GENE EXPRESSION; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 2; GLUTAMINE; GLYBURIDE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; KETO ACIDS; LEUCINE; MANNOHEPTULOSE; PHOSPHORYLATION; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 84937642550     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.05.072     Document Type: Article

References (43)

1. J. Miyazaki, K. Araki, E. Yamato, and et al. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms Endocrinology 127 1990 126 132
2. M. Asfari, D. Janjic, P. Meda, and et al. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines Endocrinology 130 1992 167 178
3. P. Ravassard, Y. Hazhouz, S. Pechberty, and et al. A genetically engineered human pancreatic beta cell line exhibiting glucose-inducible insulin secretion J. Clin. Invest 121 2011 3589 3597
4. R. Scharfmann, S. Pechberty, Y. Hazhouz, and et al. Development of a conditionally immortalized human pancreatic beta cell line J. Clin. Invest 124 2014 2087 2098
5. D.G. Pipeleers, P.A. in't Veld, M. Van de Winkel, and et al. A new in vitro model for the study of pancreatic A and B cells Endocrinology 117 1985 806 816
6. G. Parnaud, D. Bosco, T. Berney, and et al. Proliferation of sorted human and rat beta cells Diabetologia 51 2008 91 100
7. M.J. Smelt, M.M. Faas, B.J. de Haan, and et al. Pancreatic beta-cell purification by altering FAD and NAD(P)H metabolism Exp. Diabetes Res. 2008 2008 165360
8. M. Banerjee, and T. Otonkoski A simple two-step protocol for the purification of human pancreatic beta cells Diabetologia 52 2009 621 625
9. R.N. Kulkarni, and A.F. Stewart Summary of the keystone islet workshop (April 2014): the increasing demand for human islet availability in diabetes research Diabetes 63 2014 3979 3981
10. A. Bruni, B. Gala-Lopez, A.R. Pepper, and et al. Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges Diabetes Metab. Syndr. Obes. 7 2014 211 223
11. E. Gurgul-Convey, I. Mehmeti, S. Lortz, and et al. Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria J. Mol. Med. 89 2011 785 798
12. M. Elsner, M. Tiedge, B. Guldbakke, and et al. Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan Diabetologia 45 2002 1542 1549
13. M.T. Kaminski, S. Lenzen, and S. Baltrusch Real-time analysis of intracellular glucose and calcium in pancreatic beta cells by fluorescence microscopy Biochim. Biophys. Acta 1823 2012 1697 1707
14. E. Gurgul-Convey, K. Hanzelka, and S. Lenzen Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion Endocrinology 153 2012 2612 2622
15. S. Kacheva, S. Lenzen, and E. Gurgul-Convey Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide Cytokine 55 2011 195 201
16. K. Hanzelka, L. Skalniak, J. Jura, and et al. Effects of the novel mitochondrial protein mimitin in insulin-secreting cells Biochem. J. 445 2012 349 359
17. G.M. Grodsky, A.A. Batts, L.L. Bennett, and et al. Effects of carbohydrates on secretion of insulin from isolated rat pancreas Am. J. Physiol. 205 1963 638 644
18. S.J. Ashcroft, and P.J. Randle Enzymes of glucose metabolism in normal mouse pancreatic islets Biochem. J. 119 1970 5 15
19. S. Lenzen Insulin secretion by isolated perfused rat and mouse pancreas Am. J. Physiol. 236 1979 E391 E400
20. S. Lenzen, and U. Panten Signal recognition by pancreatic β-cells Biochem. Pharmacol. 37 1988 371 378
21. S. Lenzen A fresh view of glycolysis and glucokinase regulation: history and current status J. Biol. Chem. 289 2014 12189 12194
22. S.J. Ashcroft, J.M. Bassett, and P.J. Randle Insulin secretion mechanisms and glucose metabolism in isolated islets Diabetes 21 1972 538 545
23. P. Detimary, S. Dejonghe, Z. Ling, and et al. The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets J. Biol. Chem. 273 1998 33905 33908
24. U. Panten, and S. Lenzen Alterations of energy metabolism of secretory cells J.W.N. Akkerman, The Energetics of Secretion Response 1988 CRC Press Boca Raton 109 123
25. U. Panten, B.J. Zünkler, S. Scheit, and et al. Regulation of energy metabolism in pancreatic islets by glucose and tolbutamide Diabetologia 29 1986 648 654
26. M.Y. Donath, M. Boni-Schnetzler, H. Ellingsgaard, and et al. Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes Physiol. (Bethesda) 24 2009 325 331
27. K. Maedler, P. Sergeev, F. Ris, and et al. Glucose-induced beta cell production of IL-1β contributes to glucotoxicity in human pancreatic islets J. Clin. Invest 110 2002 851 860
28. A. Jörns, T. Arndt, A. Meyer zu Vilsendorf, and et al. Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes Diabetologia 57 2014 512 521
29. A. De Vos, H. Heimberg, E. Quartier, and et al. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression J. Clin. Invest. 96 1995 2489 2495
30. J. Ferrer, C. Benito, and R. Gomis Pancreatic islet GLUT2 glucose transporter mRNA and protein expression in humans with and without NIDDM Diabetes 44 1995 1369 1374
31. M. Tiedge, T. Richter, and S. Lenzen Importance of cysteine residues for the stability and catalytic activity of human pancreatic beta cell glucokinase Arch. Biochem. Biophys. 375 2000 251 260
32. F.J. Bedoya, J.M. Wilson, A.K. Ghosh, and et al. The glucokinase glucose sensor in human pancreatic islet tissue Diabetes 35 1986 61 67
33. S. Baltrusch, H. Schmitt, A. Brix, and et al. Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260 Biochem. Pharmacol. 83 2012 1300 1306
34. U. Panten, E. Kriegstein, W. Poser, and et al. Effects of L-leucine and alpha-ketoisocaproic acid upon insulin secretion and metabolism of isolated pancreatic islets FEBS Lett. 20 1972 225 228
35. F. Reimann, S.J. Tucker, P. Proks, and et al. Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor J. Physiol. 518 Pt 2 1999 325 336
36. D.L. Cook, C.N. Hales, and L.S. Satin Glucose suppresses ATP-inhibited K-channels in pancreatic beta-cells Adv. Exp. Med. Biol. 211 1986 63 67
37. S. Seino Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea Diabetologia 55 2012 2096 2108
38. U. Panten, S. Zielmann, M.T. Schrader, and et al. The dihydropyridine derivative, Bay K 8644, enhances insulin secretion by isolated pancreatic islets Naunyn Schmiedeb. Arch. Pharmacol. 328 1985 351 353
39. J.C. Henquin, D. Dufrane, and M. Nenquin Nutrient control of insulin secretion in isolated normal human islets Diabetes 55 2006 3470 3477
40. M. Komatsu, Y. Sato, S. Yamada, and et al. Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon Diabetes 51 2002 S29 S32
41. N. Sekine, V. Cirulli, R. Regazzi, and et al. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing J. Biol. Chem. 269 1994 4895 4902
42. O. Alcazar, M. Tiedge, and S. Lenzen Importance of lactate dehydrogenase for the regulation of glycolytic flux and insulin secretion in insulin-producing cells Biochem. J. 352 2000 373 380
43. N.S. Kayton, G. Poffenberger, J. Henske, and et al. Human islet preparations distributed for research exhibit a variety of insulin secretory profiles Am. J. Physiol. Endocrinol. Metab. 308 2015 E592 E602