Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria

Journal of Molecular Medicine

Volumn 89, Issue 8, 2011, Pages 785-798

  Gurgul Convey, Ewa ^a   Mehmeti, Ilir ^a   Lortz, Stephan ^a   Lenzen, Sigurd ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cytokines; Hydroxyl radical; Insulin producing cells; Mitochondria; Nitro oxidative stress; Peroxynitrite

Indexed keywords

ACETIC ACID DERIVATIVE; CYTOKINE; DICHLOROFLUORESCEIN DIACETATE; HYDROGEN PEROXIDE; HYDROXYL GROUP; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; IRON; NITRIC OXIDE; NITRITE; PEROXYNITRITE; RADICAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CLONING; CELL DEATH; CONTROLLED STUDY; INSULIN SYNTHESIS; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; TOXICITY TESTING;

ANIMALS; ANTIOXIDANTS; CASPASE 3; CELL LINE; CLONE CELLS; CYTOKINES; ENZYME INHIBITORS; FLUORESCEINS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; INSULIN; INSULIN-SECRETING CELLS; MITOCHONDRIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEROXYNITROUS ACID; RATS; RATS, INBRED LEW; TYROSINE;

EID: 80052492726     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0747-1     Document Type: Article

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