Ability of the encephalitic arbovirus semliki forest virus to cross the blood-brain barrier is determined by the charge of the E2 glycoprotein

Journal of Virology

Volumn 89, Issue 15, 2015, Pages 7536-7549

  Ferguson, Mhairi C ^a,c   Saul, Sirle ^b   Fragkoudis, Rennos ^a,c   Weisheit, Sabine ^a   Cox, Jonathan ^d   Patabendige, Adjanie ^d   Sherwood, Karen ^c,f   Watson, Mick ^e   Merits, Andres ^b   Fazakerley, John K ^a,c  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^b UNIVERSITY OF TARTU   (Estonia)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GLUTAMIC ACID; GLYCOPROTEIN E2; GLYCOSAMINOGLYCAN; LYSINE; VIRUS ENVELOPE PROTEIN;

ALPHAVIRUS; ANIMAL EXPERIMENT; ARBOVIRUS; ARTICLE; BLOOD BRAIN BARRIER; CHIKUNGUNYA VIRUS; CONTROLLED STUDY; DNA MODIFICATION; GENE MAPPING; HIGH THROUGHPUT SEQUENCING; IN SITU HYBRIDIZATION; IN VITRO STUDY; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; REAL TIME POLYMERASE CHAIN REACTION; SEMLIKI FOREST VIRUS; SINDBIS VIRUS; VIREMIA; VIRUS INFECTION; VIRUS REPLICATION; VIRUS VIRULENCE; ALPHAVIRUS INFECTION; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; BRAIN; CHEMISTRY; ENCEPHALITIS; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MOLECULAR GENETICS; PATHOGENICITY; PROTEIN MOTIF; VIROLOGY; VIRULENCE;

ARBOVIRUS; MUS; SEMLIKI FOREST VIRUS;

ALPHAVIRUS INFECTIONS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; ENCEPHALITIS; FEMALE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; SEMLIKI FOREST VIRUS; VIRAL ENVELOPE PROTEINS; VIREMIA; VIRULENCE;

EID: 84937617519     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03645-14     Document Type: Article

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