Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 38, 2011, Pages 16026-16031

  Gardner, Christina L ^a   Ebel, Gregory D ^b   Ryman, Kate D ^a   Klimstra, William B ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

Glycosaminoglycan; Innate immunity; Interferon

Indexed keywords

CHEMOKINE; CYTOKINE; HEPARAN SULFATE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EASTERN EQUINE ENCEPHALOMYELITIS VIRUS; FEVER; LYMPHOID TISSUE; MOUSE; NEUROLOGIC DISEASE; NEUROVIRULENCE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEIZURE; VIRUS ATTACHMENT; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BRAIN; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; ENCEPHALITIS VIRUS, EASTERN EQUINE; ENCEPHALOMYELITIS, EQUINE; HEPARITIN SULFATE; HORSES; INTERFERON-ALPHA; INTERFERON-BETA; LYMPHOID TISSUE; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NORTH AMERICA; SURVIVAL ANALYSIS; TIME FACTORS; VIRULENCE; VIRUS REPLICATION;

ALPHAVIRUS; ARBOVIRUS; EASTERN EQUINE ENCEPHALITIS VIRUS; MUS; SINDBIS VIRUS; TOGAVIRIDAE;

EID: 80053154735     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110617108     Document Type: Article

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