Substitutions at the putative receptor-binding site of an encephalitic flavivirus alter virulence and host cell tropism and reveal a role for glycosaminoglycans in entry

Journal of Virology

Volumn 74, Issue 19, 2000, Pages 8867-8875

  Lee, E ^a   Lobigs, M ^a  

^a Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSAMINOGLYCAN; MUTANT PROTEIN; VIRUS ENVELOPE PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; ENCEPHALITIS VIRUS; FLAVIVIRUS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; VIROGENESIS; VIRUS ADSORPTION; VIRUS CELL INTERACTION; VIRUS INFECTIVITY; VIRUS VIRULENCE;

ANIMAL; ENCEPHALITIS VIRUS, MURRAY VALLEY; GLYCOSAMINOGLYCANS; MICE; RECEPTORS, VIRUS; VIRAL ENVELOPE PROTEINS; VIRULENCE; VIRUS REPLICATION;

EID: 0033804366     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.19.8867-8875.2000     Document Type: Article

References (50)

1. Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein
2. Functions of cell surface heparan sulfate proteoglycans
3. Binding of Sindbis virus to cell surface heparan sulfate
4. Large-plaque mutants of Sindbis virus show reduced binding to heparan sulfate, heightened viremia, and slower clearance from the circulation
5. Sequence analysis of the viral core protein and the membrane-associated proteins V1 and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteins
6. Flavivirus genome organization, expression, and replication
7. Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate
8. Nucleotide and complete amino acid sequences of Kunjin virus: Definitive gene order and characteristics of the virus-specified proteins
9. Murray Valley encephalitis: Isolation and characterization of the aetiological agent
10. The uncoating and infectivity of the flavivirus West Nile on interaction with cells: Effects of pH and ammonium chloride
11. Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it
12. Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses
13. A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model
14. Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice
15. Analysis of the steps involved in Dengue virus entry into host cells
16. Arginineglycine-aspartic acid-specific binding by foot-and-mouth disease viruses to the purified integrin alpha(v)beta3 in vitro
17. Completion of kunjin virus RNA sequence and recovery of an infectious RNA transcribed from stably cloned full-length cDNA
18. The effect of pH on the early interaction of West Nile virus with P388D1 cells
19. Analysis of virus-cell binding characteristics on the determination of Japanese encephalitis virus susceptibility
20. Construction of infectious cDNA clones for dengue 2 virus: Strain 16681 and its attenuated vaccine derivative, strain PDK-53
21. Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor
22. A putative host cell receptor for tick-borne encephalitis virus identified by anti-idiotypic antibodies and virus affinoblotting
23. Infectious RNA transcribed from stably cloned full-length cDNA of dengue type 4 virus
24. Murray Valley encephalitis virus field strains from Australia and Papua New Guinea: Studies on the sequence of the major envelope protein gene and virulence for mice
25. Host cell selection of Murray Valley encephalitis virus variants altered at an RGD sequence in the envelope protein and in mouse virulence
26. The nucleotide sequence of dengue type 4 virus: Analysis of genes coding for nonstructural proteins
27. Tick-borne encephalitis virus interaction with the target cells
28. Infectious cDNA clones of tick-borne encephalitis virus European subtype prototypic strain Neudoerfl and high virulence strain Hypr
29. Sequence of the structural proteins of tick-borne encephalitis virus (western subtype) and comparative analysis with other flaviviruses
30. Sequence of the dengue-1 virus genome in the region encoding the three structural proteins and the major nonstructural protein NS1
31. Partial nucleotide sequence of the Japanese encephalitis virus genome
32. Variation in virulence for mice and rhesus monkeys among St. Louis encephalitis virus strains of different origin
33. Flaviviruses
34. Foot-and-mouth disease virus virulent for cattle utilizes the integrin alpha(v)beta3 as its receptor
35. A putative cellular receptor for dengue viruses
36. A 65-kDa trypsin-sensible membrane cell protein as a possible receptor for dengue virus in cultured neuroblastoma cells
37. The envelope glycoprotein from tick-borne encephalitis virus at 2 angstrom resolution
38. Transcription of infectious yellow fever RNA from full-length cDNA templates produced by in vitro ligation
39. Nucleotide sequence of yellow fever virus: Implications for flavivirus gene expression and evolution
40. Entry of coxsackievirus A9 into host cells: Specific interactions with alpha v beta 3 integrin, the vitronectin receptor
41. Microbial adherence to and invasion through proteoglycans
42. New perspectives in cell adhesion: RGD and integrins
43. Tissue culture adaptation of foot-and-mouth disease virus selects viruses that bind to heparin and are attenuated in cattle
44. Identification of two surface proteins from C6/36 cells that bind dengue type 4 virus
45. Signal peptidase cleavage at the flavivirus C-prM junction: Dependence on the viral NS2B-3 protease for efficient processing requires determinants in C, the signal peptide, and prM
46. Infectious Japanese encephalitis virus RNA can be synthesized from in vitro-ligated cDNA templates
47. Partial nucleotide sequence of St. Louis encephalitis virus RNA: Structural proteins, NS1, ns2a, and ns2b
48. Pathogenesis of viral infection
49. Mutagenesis of the RGD motif in the yellow fever virus 17D envelope protein