Asymmetric processing of mutant factor X Arg386Cys reveals differences between intrinsic and extrinsic pathway activation

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1854, Issue 10, 2015, Pages 1351-1356

  Baroni, M ^a   Pavani, G ^a,b   Pinotti, M ^a   Branchini, A ^a   Bernardi, F ^a   Camire, R M ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Activation determinant; Amino acid substitution; Coagulation serine proteases; Factor X; Factor X deficiency; Recombinant expression

Indexed keywords

ALANINE; ARGININE; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 8A; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR 9A; CHYMOTRYPSIN; CYSTEINE; LIGAND; RECOMBINANT PROTEIN; THIOL; THROMBIN; BLOOD CLOTTING FACTOR 10A; METALLOPROTEINASE; PROTEIN BINDING; RUSSELLYSIN;

ANIMAL EXPERIMENT; ARTICLE; BIOCHEMICAL ANALYSIS; BLEEDING TENDENCY; BLOOD CLOTTING; BLOOD CLOTTING FACTOR 10 DEFICIENCY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME KINETICS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RARE DISEASE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANIMAL; BLOOD CLOTTING TEST; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; HEK293 CELL LINE; HUMAN; KINETICS; METABOLISM; MUTATION;

MUS;

ANIMALS; BLOOD COAGULATION; BLOOD COAGULATION TESTS; CATALYTIC DOMAIN; FACTOR IXA; FACTOR VIIIA; FACTOR X; FACTOR XA; HEK293 CELLS; HUMANS; KINETICS; METALLOENDOPEPTIDASES; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; RECOMBINANT PROTEINS; THROMBIN;

EID: 84937596938     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2015.05.012     Document Type: Article

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