Cardiac Metabolic Alterations in Hypertensive Obese Pigs

Hypertension

Volumn 66, Issue 2, 2015, Pages 430-436

  Zhang, Xin ^a   Li, Zi Lun ^a,b   Eirin, Alfonso ^a   Ebrahimi, Behzad ^a   Pawar, Aditya S ^a   Zhu, Xiang Yang ^a   Lerman, Amir ^a   Lerman, Lilach O ^a  

^a MAYO CLINIC   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Hypertension; Mitochondrial turnover; Obesity; Renal artery stenosis

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL PROTEIN; STRUCTURAL PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DISEASE EXACERBATION; DNA CONTENT; ENZYME ACTIVITY; EXPERIMENTAL PIG; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE FIBROSIS; HEART MUSCLE PERFUSION; HYPERTENSION; LEFT VENTRICULAR DIASTOLIC DYSFUNCTION; MITOCHONDRIAL DYNAMICS; MITOPHAGY; NONHUMAN; OBESITY; OXYGENATION; PRIORITY JOURNAL; RENOVASCULAR HYPERTENSION; RESPIRATORY CHAIN; ADVERSE EFFECTS; ANIMAL; COMPLICATION; DISEASE MODEL; ELECTRON TRANSPORT; FIBROSIS; HEART LEFT VENTRICLE FUNCTION; HEART MITOCHONDRION; HEART MUSCLE; HEMODYNAMICS; LIPID DIET; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PIG;

ANIMALS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT; FIBROSIS; HEMODYNAMICS; HYPERTENSION; MITOCHONDRIA, HEART; MYOCARDIUM; OBESITY; OXIDATIVE STRESS; SWINE; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84937565749     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.05478     Document Type: Article

References (39)

1. Ogden CL, Carroll MD, Kit BK, Flegal KM., Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014;311:806-814. doi: 10.1001/jama.2014.732
2. Wee CC, Girotra S, Weinstein AR, Mittleman MA, Mukamal KJ., The relationship between obesity and atherosclerotic progression and prognosis among patients with coronary artery bypass grafts the effect of aggressive statin therapy. J Am Coll Cardiol 2008;52:620-625. doi: 10.1016/j.jacc.2008.05.021
3. Coutinho T, Goel K, Corrêa de Sá D, Combining body mass index with measures of central obesity in the assessment of mortality in subjects with coronary disease: Role of "normal weight central obesity". J Am Coll Cardiol 2013;61:553-560. doi: 10.1016/j.jacc.2012.10.035
4. Chang Y, Kim BK, Yun KE, Cho J, Zhang Y, Rampal S, Zhao D, Jung HS, Choi Y, Ahn J, Lima JA, Shin H, Guallar E, Ryu S., Metabolically-healthy obesity and coronary artery calcification. J Am Coll Cardiol 2014;63:2679-2686. doi: 10.1016/j.jacc.2014.03.042
5. Olivotto I, Maron BJ, Tomberli B, Appelbaum E, Salton C, Haas TS, Gibson CM, Nistri S, Servettini E, Chan RH, Udelson JE, Lesser JR, Cecchi F, Manning WJ, Maron MS., Obesity and its association to phenotype and clinical course in hypertrophic cardiomyopathy. J Am Coll Cardiol 2013;62:449-457. doi: 10.1016/j.jacc.2013.03.062
6. Tobias DK, Pan A, Jackson CL, O'Reilly EJ, Ding EL, Willett WC, Manson JE, Hu FB., Body-mass index and mortality among adults with incident type 2 diabetes. N Engl J Med 2014;370:233-244. doi: 10.1056/NEJMoa1304501
7. Lipina C, Macrae K, Suhm T, Weigert C, Blachnio-Zabielska A, Baranowski M, Gorski J, Burgess K, Hundal HS., Mitochondrial substrate availability and its role in lipid-induced insulin resistance and proinflammatory signaling in skeletal muscle. Diabetes 2013;62:3426-3436. doi: 10.2337/db13-0264
8. Abel ED., Obesity stresses cardiac mitochondria even when you are young. J Am Coll Cardiol 2011;57:586-589. doi: 10.1016/j.jacc.2010.09.039
9. Sparks LM, Xie H, Koza RA, Mynatt R, Hulver MW, Bray GA, Smith SR., A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 2005;54:1926-1933.
10. Hirabara SM, Curi R, Maechler P., Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells. J Cell Physiol 2010;222:187-194. doi: 10.1002/jcp.21936
11. Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED., Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation 2005;112:2686-2695. doi: 10.1161/CIRCULATIONAHA.105.554360
12. Julius S, Valentini M, Palatini P., Overweight and hypertension: A 2-way street? Hypertension 2000;35:807-813.
13. Losito A, Fagugli RM, Zampi I, Parente B, de Rango P, Giordano G, Cao P., Comparison of target organ damage in renovascular and essential hypertension. Am J Hypertens 1996;9:1062-1067.
14. Mehta PK, Griendling KK., Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 2007 292 C82 C97. doi: 10.1152/ajpcell.00287.2006
15. Zhang X, Li ZL, Crane JA, Jordan KL, Pawar AS, Textor SC, Lerman A, Lerman LO., Valsartan regulates myocardial autophagy and mitochondrial turnover in experimental hypertension. Hypertension 2014;64:87-93. doi: 10.1161/HYPERTENSIONAHA.113.02151
16. Eirin A, Ebrahimi B, Zhang X, Zhu XY, Woollard JR, He Q, Textor SC, Lerman A, Lerman LO., Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease. Cardiovasc Res 2014;103:461-472. doi: 10.1093/cvr/cvu157
17. Lavi S, Yang EH, Prasad A, Mathew V, Barsness GW, Rihal CS, Lerman LO, Lerman A., The interaction between coronary endothelial dysfunction, local oxidative stress, and endogenous nitric oxide in humans. Hypertension 2008;51:127-133. doi: 10.1161/HYPERTENSIONAHA.107.099986
18. Chen C, Jiang J, Lü JM, Chai H, Wang X, Lin PH, Yao Q., Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol 2010 299 H193 H201. doi: 10.1152/ajpheart.00431.2009
19. Nisoli E, Carruba MO., Nitric oxide and mitochondrial biogenesis. J Cell Sci 2006 119 pt 14;2855:2862. doi: 10.1242/jcs.03062
20. Scarpulla RC., Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta 2011;1813:1269-1278. doi: 10.1016/j.bbamcr.2010.09.019
21. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM., Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999;98:115-124. doi: 10.1016/S0092-8674(00)80611-X
22. Schon EA, DiMauro S, Hirano M., Human mitochondrial DNA: Roles of inherited and somatic mutations. Nat Rev Genet 2012;13:878-890. doi: 10.1038/nrg3275
23. Dhar SS, Ongwijitwat S, Wong-Riley MT., Nuclear respiratory factor 1 regulates all ten nuclear-encoded subunits of cytochrome c oxidase in neurons. J Biol Chem 2008;283:3120-3129. doi: 10.1074/jbc.M707587200
24. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ., Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010;464:104-107. doi: 10.1038/nature08780
25. Abadir PM, Foster DB, Crow M, Cooke CA, Rucker JJ, Jain A, Smith BJ, Burks TN, Cohn RD, Fedarko NS, Carey RM, O'Rourke B, Walston JD., Identification and characterization of a functional mitochondrial angiotensin system. Proc Natl Acad Sci U S A 2011;108:14849-14854. doi: 10.1073/pnas.1101507108
26. Díez J, Querejeta R, López B, González A, Larman M, Martínez Ubago JL., Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients. Circulation 2002;105:2512-2517.
27. Zhang X, Li ZL, Woollard JR, Eirin A, Ebrahimi B, Crane JA, Zhu XY, Pawar AS, Krier JD, Jordan KL, Tang H, Textor SC, Lerman A, Lerman LO., Obesity-metabolic derangement preserves hemodynamics but promotes intrarenal adiposity and macrophage infiltration in swine renovascular disease. Am J Physiol Renal Physiol 2013 305 F265 F276. doi: 10.1152/ajprenal.00043.2013
28. Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintrón M, Chen T, Marcinek DJ, Dorn GW II, Kang YJ, Prolla TA, Santana LF, Rabinovitch PS., Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circ Res 2011;108:837-846. doi: 10.1161/CIRCRESAHA.110.232306
29. Eirin A, Williams BJ, Ebrahimi B, Zhang X, Crane JA, Lerman A, Textor SC, Lerman LO., Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension. J Hypertens 2014;32:154-165. doi: 10.1097/HJH.0b013e3283658a53
30. Diamant M, Lamb HJ, Groeneveld Y, Endert EL, Smit JW, Bax JJ, Romijn JA, de Roos A, Radder JK., Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus. J Am Coll Cardiol 2003;42:328-335.
31. Watanabe A, Arai M, Koitabashi N, Niwano K, Ohyama Y, Yamada Y, Kato N, Kurabayashi M., Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription. Cardiovasc Res 2011;90:57-67. doi: 10.1093/cvr/cvq374
32. Riehle C, Wende AR, Zaha VG, PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res 2011;109:783-793. doi: 10.1161/CIRCRESAHA.111.243964
33. Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM., Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A 2006;103:10086-10091. doi: 10.1073/pnas.0603615103
34. Walther T, Tschöpe C, Sterner-Kock A, Westermann D, Heringer-Walther S, Riad A, Nikolic A, Wang Y, Ebermann L, Siems WE, Bader M, Shakibaei M, Schultheiss HP, Dörner A., Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease. Circulation 2007;115:333-344. doi: 10.1161/CIRCULATIONAHA.106.643296
35. Engeli S, Böhnke J, Gorzelniak K, Janke J, Schling P, Bader M, Luft FC, Sharma AM., Weight loss and the renin-angiotensin-aldosterone system. Hypertension 2005;45:356-362. doi: 10.1161/01.HYP.0000154361.47683.d3
36. Tobar A, Ori Y, Benchetrit S, Milo G, Herman-Edelstein M, Zingerman B, Lev N, Gafter U, Chagnac A., Proximal tubular hypertrophy and enlarged glomerular and proximal tubular urinary space in obese subjects with proteinuria. PLoS One 2013 8 e75547. doi: 10.1371/journal.pone.0075547
37. Smith MM, Minson CT., Obesity and adipokines: Effects on sympathetic overactivity. J Physiol 2012 590 pt 8;1787:1801. doi: 10.1113/jphysiol.2011.221036
38. Nakamura M, Yamazaki O, Shirai A, Horita S, Satoh N, Suzuki M, Hamasaki Y, Noiri E, Kume H, Enomoto Y, Homma Y, Seki G., Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome. Kidney Int 2015;87:535-542. doi: 10.1038/ki.2014.351
39. Cook CC, Kim A, Terao S, Gotoh A, Higuchi M., Consumption of oxygen: A mitochondrial-generated progression signal of advanced cancer. Cell Death Dis 2012 3 e258. doi: 10.1038/cddis.2011.141