PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

FASEB Journal

Volumn 29, Issue 4, 2015, Pages 1185-1197

  Shih, Diana M ^a   Yu, Janet M ^a   Vergnes, Laurent ^b   Dali Youcef, Nassim ^c,d   Champion, Matthew D ^e   Devarajan, Asokan ^b   Zhang, Peixiang ^b   Castellani, Lawrence W ^a   Brindley, David N ^f   Jamey, Carole ^d   Auwerx, Johan ^g   Reddy, Srinivasa T ^a,b   Ford, David A ^e   Reue, Karen ^a,b   Lusis, Aldons J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d UNIVERSITÉ DE STRASBOURG   (France)

^e SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF ALBERTA   (Canada)

^g EPFL   (Switzerland)

Author keywords

Bile acid; Cholesterol; Hyperlipidemia; Mitochondria; Mitochondria associated membrane

Indexed keywords

ALANINE AMINOTRANSFERASE; APOLIPOPROTEIN E; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILIRUBIN GLUCURONIDE; CHEMOKINE; CHOLIC ACID; ESTERASE; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; INTERMEDIATE DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; PARAOXONASE 3; PHOSPHATIDATE PHOSPHATASE; SUPEROXIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ARYLDIALKYLPHOSPHATASE; AUTACOID; CCL2 PROTEIN, MOUSE; CHOLESTEROL INTAKE; PON3 PROTEIN, MOUSE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; BILE ACID METABOLISM; BILE ACID SYNTHESIS; BODY WEIGHT; CELL DEATH; CELL SIZE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FOOD INTAKE; GALLSTONE; GALLSTONE FORMATION; GENE INACTIVATION; GENETIC SUSCEPTIBILITY; HYPERLIPIDEMIA; KNOCKOUT MOUSE; LIPID BILE LEVEL; LIPID DIET; LIPID LIVER LEVEL; LIPID METABOLISM; LIVER CELL; LIVER TOXICITY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OBESITY; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBCUTANEOUS FAT; WESTERN DIET; WHITE ADIPOSE TISSUE; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; DEFICIENCY; DIET; DISEASE MODEL; ENZYMOLOGY; FEMALE; GALLSTONES; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETICS; KIDNEY; LIVER; LIVER MITOCHONDRION; METABOLISM; SMALL INTESTINE;

MUS;

ANIMALS; APOLIPOPROTEINS E; ARYLDIALKYLPHOSPHATASE; ATHEROSCLEROSIS; BILE ACIDS AND SALTS; CHEMOKINE CCL2; CHOLESTEROL, DIETARY; CHOLIC ACID; DIET; DISEASE MODELS, ANIMAL; FEMALE; GALLSTONES; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; INFLAMMATION MEDIATORS; INTERLEUKIN-6; INTESTINE, SMALL; KIDNEY; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; OBESITY;

EID: 84937540673     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-260570     Document Type: Article

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