Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 302, Issue 1, 2012, Pages

  Kempster, Sarah L ^a,b   Belteki, Gusztav ^a,c   Licence, Diana ^a   Charnock Jones, D Stephen ^a   Smith, Gordon C S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Fetus; Neonate

Indexed keywords

ARYLDIALKYLPHOSPHATASE; PARAOXONASE 3; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROLIFERATION; EMBRYO DEATH; FETUS DEATH; HUMAN; HUMAN CELL; MOUSE; NEWBORN DEATH; NONHUMAN; OXIDATIVE STRESS; PREMATURITY; PRIORITY JOURNAL; PROGENY;

ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; ARYLDIALKYLPHOSPHATASE; CELL LINE; CELL PROLIFERATION; CROSSES, GENETIC; FEMALE; FETAL VIABILITY; GENE KNOCKOUT TECHNIQUES; GENE SILENCING; GENES, LETHAL; HETEROZYGOTE; HUMANS; LIVER; LUNG; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; PREGNANCY; RNA, SMALL INTERFERING;

EID: 83455197120     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00357.2011     Document Type: Article

References (19)

1. Belteki G, Kempster SL, Forhead AJ, Giussani DA, Fowden AL, Curley A, Charnock-Jones DS, Smith GC. Paraoxonase-3, a putative circulating antioxidant, is systemically up-regulated in late gestation in the fetal rat, sheep, and human. J Clin Endocrinol Metab 95: 3798-3805, 2010.
2. Brion LP, Bell EF, Raghuveer TS. Vitamin E supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev CD003665, 2003.
3. Davis JM, Auten RL. Maturation of the antioxidant system and the effects on preterm birth. Semin Fetal Neonatal Med 15: 191-195, 2010.
4. Draganov DI, Stetson PL, Watson CE, Billecke SS, La Du BN. Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation. J Biol Chem 275: 33435-33442, 2000.
5. Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. J Lipid Res 46: 1239-1247, 2005.
6. Hamatani T, Carter MG, Sharov AA, Ko MS. Dynamics of global gene expression changes during mouse preimplantation development. Dev Cell 6: 117-131, 2004.
7. Jankov RP, Negus A, Tanswell AK. Antioxidants as therapy in the newborn: some words of caution. Pediatr Res 50: 681-687, 2001.
8. Lyrene RK, Philips JB 3rd. Control of pulmonary vascular resistance in the fetus and newborn. Clin Perinatol 11: 551-564, 1984.
9. Murphy WJ, Pringle TH, Crider TA, Springer MS, Miller W. Using genomic data to unravel the root of the placental mammal phylogeny. Genome Res 17: 413-421, 2007.
10. Ono R, Shiura H, Aburatani H, Kohda T, Kaneko-Ishino T, Ishino F. Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6. Genome Res 13: 1696-1705, 2003.
11. Peng W, Jiang X, Haiqin L, Zhang C, Zhu J, Zhang J, Zang Y, Qin J. Protective effects of transgene expressed human PON3 against CCl4-induced subacute liver injury in mice. Biomed Pharmacother 63: 592-598, 2009.
12. Precourt LP, Amre D, Denis MC, Lavoie JC, Delvin E, Seidman E, Levy E. The three-gene paraoxonase family: physiologic roles, actions and regulation. Atherosclerosis 214: 20-36, 2011.
13. Smirnov IM, Bailey K, Flowers CH, Garrigues NW, Wesselius LJ. Effects of TNF- and IL-1β on iron metabolism by A549 cells and influence on cytotoxicity. Am J Physiol Lung Cell Mol Physiol 277: L257-L263, 1999.
14. Smith BT. Cell line A549: a model system for the study of alveolar type II cell function. Am Rev Respir Dis 115: 285-293, 1977.
15. Smith GC. The pharmacology of the ductus arteriosus. Pharmacol Rev 50: 35-58, 1998.
16. Soghier LM, Brion LP. Cysteine, cystine or N-acetylcysteine supplementation in parenterally fed neonates. Cochrane Database Syst Rev CD004869, 2006.
17. Stoltz DA, Ozer EA, Ng CJ, Yu JM, Reddy ST, Lusis AJ, Bourquard N, Parsek MR, Zabner J, Shih DM. Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia. Am J Physiol Lung Cell Mol Physiol 292: L852-L860, 2007.
18. Suresh GK, Davis JM, Soll RF. Superoxide dismutase for preventing chronic lung disease in mechanically ventilated preterm infants. Cochrane Database Syst Rev CD001968, 2001.
19. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: RESEARCH0034, 2002.