-
1
-
-
76149111947
-
Inflammatory lipid mediators in adipocyte function and obesity
-
Iyer, A., Fairlie, D. P., Prins, J. B., Hammock, B. D., and Brown, L. (2010) Inflammatory lipid mediators in adipocyte function and obesity. Nat. Rev. Endocrinol. 6, 71-82
-
(2010)
Nat. Rev. Endocrinol.
, vol.6
, pp. 71-82
-
-
Iyer, A.1
Fairlie, D.P.2
Prins, J.B.3
Hammock, B.D.4
Brown, L.5
-
2
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil, G. S. (2006) Inflammation and metabolic disorders. Nature 444, 860-867
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
3
-
-
84865512175
-
An inhibitor of phospholipase a2 group iia modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats
-
Iyer, A., Lim, J., Poudyal, H., Reid, R. C., Suen, J. Y., Webster, J., Prins, J. B., Whitehead, J. P., Fairlie, D. P., and Brown, L. (2012) An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats. Diabetes 61, 2320-2329
-
(2012)
Diabetes
, vol.61
, pp. 2320-2329
-
-
Iyer, A.1
Lim, J.2
Poudyal, H.3
Reid, R.C.4
Suen, J.Y.5
Webster, J.6
Prins, J.B.7
Whitehead, J.P.8
Fairlie, D.P.9
Brown, L.10
-
4
-
-
68349160704
-
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
-
Liu, J., Divoux, A., Sun, J., Zhang, J., Clement, K., Glickman, J. N., Sukhova, G. K., Wolters, P. J., Du, J., Gorgun, C. Z., Doria, A., Libby, P., Blumberg, R. S., Kahn, B. B., Hotamisligil, G. S., and Shi, G. P. (2009) Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat. Med. 15, 940-945
-
(2009)
Nat. Med.
, vol.15
, pp. 940-945
-
-
Liu, J.1
Divoux, A.2
Sun, J.3
Zhang, J.4
Clement, K.5
Glickman, J.N.6
Sukhova, G.K.7
Wolters, P.J.8
Du, J.9
Gorgun, C.Z.10
Doria, A.11
Libby, P.12
Blumberg, R.S.13
Kahn, B.B.14
Hotamisligil, G.S.15
Shi, G.P.16
-
5
-
-
84873472582
-
C5ar and c3ar antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling
-
Lim, J., Iyer, A., Suen, J. Y., Seow, V., Reid, R. C., Brown, L., and Fairlie, D. P. (2013) C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. FASEB J. 27, 822-831
-
(2013)
FASEB J.
, vol.27
, pp. 822-831
-
-
Lim, J.1
Iyer, A.2
Suen, J.Y.3
Seow, V.4
Reid, R.C.5
Brown, L.6
Fairlie, D.P.7
-
6
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., and Ferrante, A. W., Jr. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
7
-
-
15844381594
-
Enhanced expression of pai-1 in visceral fat: Possible contributor to vascular disease in obesity
-
Shimomura, I., Funahashi, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., Yamashita, S., Miura, M., Fukuda, Y., Takemura, K., Tokunaga, K., and Matsuzawa, Y. (1996) Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat. Med. 2, 800-803
-
(1996)
Nat. Med.
, vol.2
, pp. 800-803
-
-
Shimomura, I.1
Funahashi, T.2
Takahashi, M.3
Maeda, K.4
Kotani, K.5
Nakamura, T.6
Yamashita, S.7
Miura, M.8
Fukuda, Y.9
Takemura, K.10
Tokunaga, K.11
Matsuzawa, Y.12
-
8
-
-
78649498271
-
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
-
Stienstra, R., Joosten, L. A., Koenen, T., van Tits, B., van Diepen, J. A., van den Berg, S. A., Rensen, P. C., Voshol, P. J., Fantuzzi, G., Hijmans, A., Kersten, S., Muller, M., van den Berg, W. B., van Rooijen, N., Wabitsch, M., Kullberg, B. J., van der Meer, J. W., Kanneganti, T., Tack, C. J., and Netea, M. G. (2010) The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab. 12, 593-605
-
(2010)
Cell Metab.
, vol.12
, pp. 593-605
-
-
Stienstra, R.1
Joosten, L.A.2
Koenen, T.3
Van Tits, B.4
Van Diepen, J.A.5
Van Den Berg, S.A.6
Rensen, P.C.7
Voshol, P.J.8
Fantuzzi, G.9
Hijmans, A.10
Kersten, S.11
Muller, M.12
Van Den Berg, W.B.13
Van Rooijen, N.14
Wabitsch, M.15
Kullberg, B.J.16
Van Der Meer, J.W.17
Kanneganti, T.18
Tack, C.J.19
Netea, M.G.20
more..
-
9
-
-
77951630662
-
Cathepsins in human obesity: Changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation
-
Naour, N., Rouault, C., Fellahi, S., Lavoie, M. E., Poitou, C., Keophiphath, M., Eberle, D., Shoelson, S., Rizkalla, S., Bastard, J. P., Rabasa-Lhoret, R., Clement, K., and Guerre-Millo, M. (2010) Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation. J. Clin. Endocrinol. Metab. 95, 1861-1868
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
, pp. 1861-1868
-
-
Naour, N.1
Rouault, C.2
Fellahi, S.3
Lavoie, M.E.4
Poitou, C.5
Keophiphath, M.6
Eberle, D.7
Shoelson, S.8
Rizkalla, S.9
Bastard, J.P.10
Rabasa-Lhoret, R.11
Clement, K.12
Guerre-Millo, M.13
-
10
-
-
0035760887
-
Regulation of tissue factor gene expression in obesity
-
Samad, F., Pandey, M., and Loskutoff, D. J. (2001) Regulation of tissue factor gene expression in obesity. Blood 98, 3353-3358
-
(2001)
Blood
, vol.98
, pp. 3353-3358
-
-
Samad, F.1
Pandey, M.2
Loskutoff, D.J.3
-
11
-
-
77956165390
-
Gpr120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
-
Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., and Olefsky, J. M. (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142, 687-698
-
(2010)
Cell
, vol.142
, pp. 687-698
-
-
Oh, D.Y.1
Talukdar, S.2
Bae, E.J.3
Imamura, T.4
Morinaga, H.5
Fan, W.6
Li, P.7
Lu, W.J.8
Watkins, S.M.9
Olefsky, J.M.10
-
12
-
-
79955584619
-
Structure, function and pathophysiology of protease activated receptors
-
Adams, M. N., Ramachandran, R., Yau, M. K., Suen, J. Y., Fairlie, D. P., Hollenberg, M. D., and Hooper, J. D. (2011) Structure, function and pathophysiology of protease activated receptors. Pharmacol. Ther. 130, 248-282
-
(2011)
Pharmacol. Ther.
, vol.130
, pp. 248-282
-
-
Adams, M.N.1
Ramachandran, R.2
Yau, M.K.3
Suen, J.Y.4
Fairlie, D.P.5
Hollenberg, M.D.6
Hooper, J.D.7
-
13
-
-
0037372534
-
Proteinase-Activated receptor-2 and human lung epithelial cells: Disarming by neutrophil serine proteinases
-
Dulon, S., Cande, C., Bunnett, N. W., Hollenberg, M. D., Chignard, M., and Pidard, D. (2003) Proteinase-Activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases. Am. J. Respir. Cell Mol. Biol. 28, 339-346
-
(2003)
Am. J. Respir. Cell Mol. Biol.
, vol.28
, pp. 339-346
-
-
Dulon, S.1
Cande, C.2
Bunnett, N.W.3
Hollenberg, M.D.4
Chignard, M.5
Pidard, D.6
-
14
-
-
18244404006
-
Pseudomonas aeruginosa elastase disables proteinaseactivated receptor 2 in respiratory epithelial cells
-
Dulon, S., Leduc, D., Cottrell, G. S., D'Alayer, J., Hansen, K. K., Bunnett, N. W., Hollenberg, M. D., Pidard, D., and Chignard, M. (2005) Pseudomonas aeruginosa elastase disables proteinaseactivated receptor 2 in respiratory epithelial cells. Am. J. Respir. Cell Mol. Biol. 32, 411-419
-
(2005)
Am. J. Respir. Cell Mol. Biol.
, vol.32
, pp. 411-419
-
-
Dulon, S.1
Leduc, D.2
Cottrell, G.S.3
D'Alayer, J.4
Hansen, K.K.5
Bunnett, N.W.6
Hollenberg, M.D.7
Pidard, D.8
Chignard, M.9
-
15
-
-
79960114650
-
Neutrophil elastase acts as a biased agonist for proteinase-Activated receptor-2 (par2
-
Ramachandran, R., Mihara, K., Chung, H., Renaux, B., Lau, C. S., Muruve, D. A., DeFea, K. A., Bouvier, M., and Hollenberg, M. D. (2011) Neutrophil elastase acts as a biased agonist for proteinase-Activated receptor-2 (PAR2). J. Biol. Chem. 286, 24638-24648
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 24638-24648
-
-
Ramachandran, R.1
Mihara, K.2
Chung, H.3
Renaux, B.4
Lau, C.S.5
Muruve, D.A.6
DeFea, K.A.7
Bouvier, M.8
Hollenberg, M.D.9
-
16
-
-
81255127280
-
Tissue factor-protease-Activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation
-
Badeanlou, L., Furlan-Freguia, C., Yang, G., Ruf, W., and Samad, F. (2011) Tissue factor-protease-Activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation. Nat. Med. 17, 1490-1497
-
(2011)
Nat. Med.
, vol.17
, pp. 1490-1497
-
-
Badeanlou, L.1
Furlan-Freguia, C.2
Yang, G.3
Ruf, W.4
Samad, F.5
-
17
-
-
77958486918
-
Novel agonists and antagonists for human protease activated receptor 2
-
Barry, G. D., Suen, J. Y., Le, G. T., Cotterell, A., Reid, R. C., and Fairlie, D. P. (2010) Novel agonists and antagonists for human protease activated receptor 2. J. Med. Chem. 53, 7428-7440
-
(2010)
J. Med. Chem.
, vol.53
, pp. 7428-7440
-
-
Barry, G.D.1
Suen, J.Y.2
Le, G.T.3
Cotterell, A.4
Reid, R.C.5
Fairlie, D.P.6
-
18
-
-
84885596692
-
Towards drugs for protease activated receptor 2 (par2). [e-pub ahead of print]
-
doi:10.1021/jm400638v
-
Yau, M. K., Liu, L., and Fairlie, D. P. (2013) Towards drugs for protease activated receptor 2 (PAR2). [E-pub ahead of print] J. Med. Chem. 56, doi:10.1021/jm400638v
-
(2013)
J. Med. Chem.
, vol.56
-
-
Yau, M.K.1
Liu, L.2
Fairlie, D.P.3
-
19
-
-
84863224546
-
An antagonist of human protease activated receptor-2 attenuates par2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats
-
Lohman, R. J., Cotterell, A. J., Barry, G. D., Liu, L., Suen, J. Y., Vesey, D. A., and Fairlie, D. P. (2012) An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 26, 2877-2887
-
(2012)
FASEB J.
, vol.26
, pp. 2877-2887
-
-
Lohman, R.J.1
Cotterell, A.J.2
Barry, G.D.3
Liu, L.4
Suen, J.Y.5
Vesey, D.A.6
Fairlie, D.P.7
-
20
-
-
84862952456
-
Antagonism of protease activated receptor 2 protects against experimental colitis
-
Lohman, R. J., Cotterell, A. J., Suen, J. Y., Liu, L., Do, T. A., Vesey, D. A., and Fairlie, D. P. (2012) Antagonism of protease activated receptor 2 protects against experimental colitis. J. Pharmacol. Exp. Ther. 340, 256-265
-
(2012)
J. Pharmacol. Exp. Ther.
, vol.340
, pp. 256-265
-
-
Lohman, R.J.1
Cotterell, A.J.2
Suen, J.Y.3
Liu, L.4
Do, T.A.5
Vesey, D.A.6
Fairlie, D.P.7
-
21
-
-
84857085346
-
Modulating human proteinase activated receptor 2 with a novel antagonist (gb88) and agonist (gb110
-
Suen, J. Y., Barry, G. D., Lohman, R. J., Halili, M. A., Cotterell, A. J., Le, G. T., and Fairlie, D. P. (2012) Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). Br. J. Pharmacol. 165, 1413-1423
-
(2012)
Br. J. Pharmacol.
, vol.165
, pp. 1413-1423
-
-
Suen, J.Y.1
Barry, G.D.2
Lohman, R.J.3
Halili, M.A.4
Cotterell, A.J.5
Le, G.T.6
Fairlie, D.P.7
-
22
-
-
78149473286
-
Profiling gene expression induced by protease-Activated receptor 2 (par2) activation in human kidney cells
-
Suen, J. Y., Gardiner, B., Grimmond, S., and Fairlie, D. P. (2010) Profiling gene expression induced by protease-Activated receptor 2 (PAR2) activation in human kidney cells. PLOS One 5, e13809
-
(2010)
PLOS One
, vol.5
-
-
Suen, J.Y.1
Gardiner, B.2
Grimmond, S.3
Fairlie, D.P.4
-
23
-
-
79957796961
-
High-carbohydrate high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats
-
Panchal, S. K., Poudyal, H., Iyer, A., Nazer, R., Alam, A., Diwan, V., Kauter, K., Sernia, C., Campbell, F., Ward, L., Gobe, G., Fenning, A., and Brown, L. (2011) High-carbohydrate high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats. J. Cardiovasc. Pharmacol. 57, 611-624
-
(2011)
J. Cardiovasc. Pharmacol.
, vol.57
, pp. 611-624
-
-
Panchal, S.K.1
Poudyal, H.2
Iyer, A.3
Nazer, R.4
Alam, A.5
Diwan, V.6
Kauter, K.7
Sernia, C.8
Campbell, F.9
Ward, L.10
Gobe, G.11
Fenning, A.12
Brown, L.13
-
24
-
-
77449092780
-
Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: Dissociation of adipocyte hypertrophy from inflammation
-
Yeop, Han C., Kargi, A. Y., Omer, M., Chan, C. K., Wabitsch, M., O'Brien, K. D., Wight, T. N., and Chait, A. (2010) Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. Diabetes 59, 386-396
-
(2010)
Diabetes
, vol.59
, pp. 386-396
-
-
Yeop Han, C.1
Kargi, A.Y.2
Omer, M.3
Chan, C.K.4
Wabitsch, M.5
O'Brien, K.D.6
Wight, T.N.7
Chait, A.8
-
25
-
-
33845611030
-
Characterization of the transcriptional and functional effects of fibroblast growth factor-1 on human preadipocyte differentiation
-
Newell, F. S., Su, H., Tornqvist, H., Whitehead, J. P., Prins, J. B., and Hutley, L. J. (2006) Characterization of the transcriptional and functional effects of fibroblast growth factor-1 on human preadipocyte differentiation. FASEB J. 20, 2615-2617
-
(2006)
FASEB J.
, vol.20
, pp. 2615-2617
-
-
Newell, F.S.1
Su, H.2
Tornqvist, H.3
Whitehead, J.P.4
Prins, J.B.5
Hutley, L.J.6
-
26
-
-
33745607930
-
Pharmacological regulation of insulin secretion in min6 cells through the fatty acid receptor gpr40: Identification of agonist and antagonist small molecules
-
Briscoe, C. P., Peat, A. J., McKeown, S. C., Corbett, D. F., Goetz, A. S., Littleton, T. R., McCoy, D. C., Kenakin, T. P., Andrews, J. L., Ammala, C., Fornwald, J. A., Ignar, D. M., and Jenkinson, S. (2006) Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br. J. Pharmacol. 148, 619-628
-
(2006)
Br. J. Pharmacol.
, vol.148
, pp. 619-628
-
-
Briscoe, C.P.1
Peat, A.J.2
McKeown, S.C.3
Corbett, D.F.4
Goetz, A.S.5
Littleton, T.R.6
McCoy, D.C.7
Kenakin, T.P.8
Andrews, J.L.9
Ammala, C.10
Fornwald, J.A.11
Ignar, D.M.12
Jenkinson, S.13
-
27
-
-
0036725464
-
Interaction between free fatty acids and glucose metabolism
-
Boden, G. (2002) Interaction between free fatty acids and glucose metabolism. Curr. Opin. Clin. Nutr. Metab. Care 5, 545-549
-
(2002)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.5
, pp. 545-549
-
-
Boden, G.1
-
28
-
-
33746860830
-
Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration
-
Johnson, E. J., and Schaefer, E. J. (2006) Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration. Am. J. Clin. Nutr. 83, 1494S-1498S
-
(2006)
Am. J. Clin. Nutr.
, vol.83
-
-
Johnson, E.J.1
Schaefer, E.J.2
-
29
-
-
80052433997
-
Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport
-
Ohtsubo, K., Chen, M. Z., Olefsky, J. M., and Marth, J. D. (2011) Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nat. Med. 17, 1067-1075
-
(2011)
Nat. Med.
, vol.17
, pp. 1067-1075
-
-
Ohtsubo, K.1
Chen, M.Z.2
Olefsky, J.M.3
Marth, J.D.4
-
30
-
-
0037265240
-
Alternative activation of macrophages
-
Gordon, S. (2003) Alternative activation of macrophages. Nat. Rev. Immunol. 3, 23-35
-
(2003)
Nat. Rev. Immunol
, vol.3
, pp. 23-35
-
-
Gordon, S.1
-
31
-
-
77954249680
-
Pro-inflammatory cd11c-cd206-Adipose tissue macrophages are associated with insulin resistance in human obesity
-
Wentworth, J. M., Naselli, G., Brown, W. A., Doyle, L., Phipson, B., Smyth, G. K., Wabitsch, M., O'Brien, P. E., and Harrison, L. C. (2010) Pro-inflammatory CD11c-CD206-Adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes 59, 1648-1656
-
(2010)
Diabetes
, vol.59
, pp. 1648-1656
-
-
Wentworth, J.M.1
Naselli, G.2
Brown, W.A.3
Doyle, L.4
Phipson, B.5
Smyth, G.K.6
Wabitsch, M.7
O'Brien, P.E.8
Harrison, L.C.9
-
32
-
-
33745216724
-
Mcp-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
-
Kanda, H., Tateya, S., Tamori, Y., Kotani, K., Hiasa, K., Kitazawa, R., Kitazawa, S., Miyachi, H., Maeda, S., Egashira, K., and Kasuga, M. (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116, 1494-1505
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1494-1505
-
-
Kanda, H.1
Tateya, S.2
Tamori, Y.3
Kotani, K.4
Hiasa, K.5
Kitazawa, R.6
Kitazawa, S.7
Miyachi, H.8
Maeda, S.9
Egashira, K.10
Kasuga, M.11
-
33
-
-
0035023128
-
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
-
Kern, P. A., Ranganathan, S., Li, C. L., Wood, L., and Ranganathan, G. (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 280, E745-E751
-
(2001)
Am. J. Physiol. Endocrinol. Metab.
, vol.280
-
-
Kern, P.A.1
Ranganathan, S.2
Li, C.L.3
Wood, L.4
Ranganathan, G.5
-
34
-
-
0028587742
-
Tumor necrosis factor alpha: A key component of the obesity-diabetes link
-
Hotamisligil, G. S., and Spiegelman, B. M. (1994) Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 43, 1271-1278
-
(1994)
Diabetes
, vol.43
, pp. 1271-1278
-
-
Hotamisligil, G.S.1
Spiegelman, B.M.2
-
35
-
-
42449097289
-
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
-
Guilherme, A., Virbasius, J. V., Puri, V., and Czech, M. P. (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9, 367-377
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 367-377
-
-
Guilherme, A.1
Virbasius, J.V.2
Puri, V.3
Czech, M.P.4
-
36
-
-
77949537265
-
Beta-Arrestin inhibits camkkbeta-dependent ampk activation downstream of protease-Activated-receptor-2
-
Wang, P., Jiang, Y., Wang, Y., Shyy, J. Y., and DeFea, K. A. (2010) Beta-Arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-Activated-receptor-2. BMC Biochem. 11, 36
-
(2010)
BMC Biochem
, vol.11
, pp. 36
-
-
Wang, P.1
Jiang, Y.2
Wang, Y.3
Shyy, J.Y.4
DeFea, K.A.5
-
37
-
-
78149280410
-
Proteaseactivated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury
-
Antoniak, S., Rojas, M., Spring, D., Bullard, T. A., Verrier, E. D., Blaxall, B. C., Mackman, N., and Pawlinski, R. (2010) Proteaseactivated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury. Arterioscl. Throm. Vasc. Biol. 30, 2136-2142
-
(2010)
Arterioscl. Throm. Vasc. Biol.
, vol.30
, pp. 2136-2142
-
-
Antoniak, S.1
Rojas, M.2
Spring, D.3
Bullard, T.A.4
Verrier, E.D.5
Blaxall, B.C.6
Mackman, N.7
Pawlinski, R.8
-
38
-
-
80051471604
-
Tryptase/protease-Activated receptor 2 interactions induce selective mitogen-Activated protein kinase signaling and collagen synthesis by cardiac fibroblasts
-
McLarty, J. L., Melendez, G. C., Brower, G. L., Janicki, J. S., and Levick, S. P. (2011) Tryptase/protease-Activated receptor 2 interactions induce selective mitogen-Activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 58, 264-270
-
(2011)
Hypertension
, vol.58
, pp. 264-270
-
-
McLarty, J.L.1
Melendez, G.C.2
Brower, G.L.3
Janicki, J.S.4
Levick, S.P.5
-
39
-
-
34248140140
-
Mast cell tryptases and chymases in inflammation and host defense
-
Caughey, G. H. (2007) Mast cell tryptases and chymases in inflammation and host defense. Immunol. Rev. 217, 141-154
-
(2007)
Immunol. Rev.
, vol.217
, pp. 141-154
-
-
Caughey, G.H.1
-
40
-
-
77955883153
-
Complement: A key system for immune surveillance and homeostasis
-
Ricklin, D., Hajishengallis, G., Yang, K., and Lambris, J. D. (2010) Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11, 785-797
-
(2010)
Nat. Immunol.
, vol.11
, pp. 785-797
-
-
Ricklin, D.1
Hajishengallis, G.2
Yang, K.3
Lambris, J.D.4
-
41
-
-
77952868792
-
Mast cell-orchestrated immunity to pathogens
-
Abraham, S. N., and St John, A. L. (2010) Mast cell-orchestrated immunity to pathogens. Nat. Rev. Immunol. 10, 440-452
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 440-452
-
-
Abraham, S.N.1
St John, A.L.2
-
42
-
-
13844276627
-
Target-based drug discovery: Is something wrong?
-
Sams-Dodd, F. (2005) Target-based drug discovery: is something wrong? Drug Discov. Today 10, 139-147
-
(2005)
Drug Discov. Today
, vol.10
, pp. 139-147
-
-
Sams-Dodd, F.1
-
43
-
-
18844432308
-
Adiponectin and adiponectin receptors
-
Kadowaki, T., and Yamauchi, T. (2005) Adiponectin and adiponectin receptors. Endocr. Rev. 26, 439-451
-
(2005)
Endocr. Rev.
, vol.26
, pp. 439-451
-
-
Kadowaki, T.1
Yamauchi, T.2
-
44
-
-
69249216477
-
Novel antagonists for proteinase-Activated receptor 2: Inhibition of cellular and vascular responses in vitro and in vivo
-
Kanke, T., Kabeya, M., Kubo, S., Kondo, S., Yasuoka, K., Tagashira, J., Ishiwata, H., Saka, M., Furuyama, T., Nishiyama, T., Doi, T., Hattori, Y., Kawabata, A., Cunningham, M. R., and Plevin, R. (2009) Novel antagonists for proteinase-Activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo. Br. J. Pharmacol. 158, 361-371
-
(2009)
Br. J. Pharmacol.
, vol.158
, pp. 361-371
-
-
Kanke, T.1
Kabeya, M.2
Kubo, S.3
Kondo, S.4
Yasuoka, K.5
Tagashira, J.6
Ishiwata, H.7
Saka, M.8
Furuyama, T.9
Nishiyama, T.10
Doi, T.11
Hattori, Y.12
Kawabata, A.13
Cunningham, M.R.14
Plevin, R.15
-
45
-
-
33947166333
-
Expression and proinflammatory role of proteinaseactivated receptor 2 in rheumatoid synovium: Ex vivo studies using a novel proteinase-Activated receptor 2 antagonist
-
Kelso, E. B., Ferrell, W. R., Lockhart, J. C., Elias-Jones, I., Hembrough, T., Dunning, L., Gracie, J. A., and McInnes, I. B. (2007) Expression and proinflammatory role of proteinaseactivated receptor 2 in rheumatoid synovium: ex vivo studies using a novel proteinase-Activated receptor 2 antagonist. Arthritis Rheum. 56, 765-771
-
(2007)
Arthritis Rheum.
, vol.56
, pp. 765-771
-
-
Kelso, E.B.1
Ferrell, W.R.2
Lockhart, J.C.3
Elias-Jones, I.4
Hembrough, T.5
Dunning, L.6
Gracie, J.A.7
McInnes, I.B.8
-
46
-
-
0141816690
-
Differential expression and regulation of protease-Activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells
-
Colognato, R., Slupsky, J. R., Jendrach, M., Burysek, L., Syrovets, T., and Simmet, T. (2003) Differential expression and regulation of protease-Activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. Blood 102, 2645-2652
-
(2003)
Blood
, vol.102
, pp. 2645-2652
-
-
Colognato, R.1
Slupsky, J.R.2
Jendrach, M.3
Burysek, L.4
Syrovets, T.5
Simmet, T.6
-
47
-
-
82255161850
-
The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-Activated receptor-2
-
Adams, M. N., Christensen, M. E., He, Y., Waterhouse, N. J., and Hooper, J. D. (2011) The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-Activated receptor-2. PLOS One 6, e28018
-
(2011)
PLOS One
, vol.6
-
-
Adams, M.N.1
Christensen, M.E.2
He, Y.3
Waterhouse, N.J.4
Hooper, J.D.5
-
48
-
-
0038757730
-
Role of palmitoylation/depalmitoylation reactions in g-protein-coupled receptor function
-
Qanbar, R., and Bouvier, M. (2003) Role of palmitoylation/ depalmitoylation reactions in G-protein-coupled receptor function. Pharmacol. Ther. 97, 1-33
-
(2003)
Pharmacol. Ther.
, vol.97
, pp. 1-33
-
-
Qanbar, R.1
Bouvier, M.2
-
49
-
-
0031564603
-
Elimination of palmitoylation sites in the human dopamine d1 receptor does not affect receptor-g protein interaction
-
Jin, H., Zastawny, R., George, S. R., and O'Dowd, B. F. (1997) Elimination of palmitoylation sites in the human dopamine D1 receptor does not affect receptor-G protein interaction. Eur. J. Pharmacol. 324, 109-116
-
(1997)
Eur. J. Pharmacol.
, vol.324
, pp. 109-116
-
-
Jin, H.1
Zastawny, R.2
George, S.R.3
O'Dowd, B.F.4
-
50
-
-
0027401994
-
Mutations of the alpha 2a-Adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-g-protein coupling
-
Kennedy, M. E., and Limbird, L. E. (1993) Mutations of the alpha 2A-Adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling. J. Biol. Chem. 268, 8003-8011
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 8003-8011
-
-
Kennedy, M.E.1
Limbird, L.E.2
-
51
-
-
0030889243
-
Role of palmitoylation of conserved cysteine residues of luteinizing hormone/human choriogonadotropin receptors in receptor down-regulation
-
Kawate, N., Peegel, H., and Menon, K. M. (1997) Role of palmitoylation of conserved cysteine residues of luteinizing hormone/human choriogonadotropin receptors in receptor down-regulation. Mol. Cell. Endocrinol. 127, 211-219
-
(1997)
Mol. Cell. Endocrinol.
, vol.127
, pp. 211-219
-
-
Kawate, N.1
Peegel, H.2
Menon, K.M.3
-
52
-
-
0031732763
-
Palmitoylation of human thyrotropin receptor: Slower intracellular trafficking of the palmitoylationdefective mutant
-
Tanaka, K., Nagayama, Y., Nishihara, E., Namba, H., Yamashita, S., and Niwa, M. (1998) Palmitoylation of human thyrotropin receptor: slower intracellular trafficking of the palmitoylationdefective mutant. Endocrinology 139, 803-806
-
(1998)
Endocrinology
, vol.139
, pp. 803-806
-
-
Tanaka, K.1
Nagayama, Y.2
Nishihara, E.3
Namba, H.4
Yamashita, S.5
Niwa, M.6
-
53
-
-
84871539770
-
Cross talk between toll-like receptor 4 (tlr4) and proteinase activated receptor 2 (par-2) is involved in vascular function
-
Bucci, M., Vellecco, V., Harrington, L., Brancaleone, V., Roviezzo, F., Mattace Raso, G., Ianaro, A., Lungarella, G., De Palma, R., Meli, R., and Cirino, G. (2013) Cross talk between toll-like receptor 4 (TLR4) and proteinase activated receptor 2 (PAR-2) is involved in vascular function. Br. J. Pharmacol. 168, 411-420
-
(2013)
Br. J. Pharmacol.
, vol.168
, pp. 411-420
-
-
Bucci, M.1
Vellecco, V.2
Harrington, L.3
Brancaleone, V.4
Roviezzo, F.5
Mattace Raso, G.6
Ianaro, A.7
Lungarella, G.8
De Palma, R.9
Meli, R.10
Cirino, G.11
-
54
-
-
54049117260
-
Analysis of proteinase-Activated receptor 2 and tlr4 signal transduction: A novel paradigm for receptor cooperativity
-
Rallabhandi, P., Nhu, Q. M., Toshchakov, V. Y., Piao, W., Medvedev, A. E., Hollenberg, M. D., Fasano, A., and Vogel, S. N. (2008) Analysis of proteinase-Activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. J. Biol. Chem. 283, 24314-24325
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 24314-24325
-
-
Rallabhandi, P.1
Nhu, Q.M.2
Toshchakov, V.Y.3
Piao, W.4
Medvedev, A.E.5
Hollenberg, M.D.6
Fasano, A.7
Vogel, S.N.8
-
55
-
-
36849052080
-
Probing cell type-specific functions of gi in vivo identifies gpcr regulators of insulin secretion
-
Regard, J. B., Kataoka, H., Cano, D. A., Camerer, E., Yin, L., Zheng, Y. W., Scanlan, T. S., Hebrok, M., and Coughlin, S. R. (2007) Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J. Clin. Invest. 117, 4034-4043
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 4034-4043
-
-
Regard, J.B.1
Kataoka, H.2
Cano, D.A.3
Camerer, E.4
Yin, L.5
Zheng, Y.W.6
Scanlan, T.S.7
Hebrok, M.8
Coughlin, S.R.9
-
56
-
-
84872576236
-
Metabolism of inflammation limited by ampk and pseudo-starvation
-
O'Neill, L. A., and Hardie, D. G. (2013) Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 493, 346-355
-
(2013)
Nature
, vol.493
, pp. 346-355
-
-
O'Neill, L.A.1
Hardie, D.G.2
|