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Volumn 417, Issue 2, 2011, Pages 202-210

Analysis of cholesteryl esters and diacylglycerols using lithiated adducts and electrospray ionization-tandem mass spectrometry

Author keywords

Cholesteryl esters; Diacylglycerols; Direct infusion electrospray; Human coronary artery endothelial cells; Lipid oxidation; Lithiated adducts; Mass spectrometry; Tandem mass spectrometry

Indexed keywords

ENDOTHELIAL CELLS; ESTERS; GLYCEROL; ION SOURCES; LIPIDS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PALMITIC ACID;

EID: 80051544556     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2011.06.015     Document Type: Article
Times cited : (33)

References (48)
  • 2
    • 18344393519 scopus 로고    scopus 로고
    • Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples
    • DOI 10.1002/mas.20023
    • X. Han, and R.W. Gross Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples Mass Spectrom. Rev. 24 2005 367 412 (Pubitemid 40665798)
    • (2005) Mass Spectrometry Reviews , vol.24 , Issue.3 , pp. 367-412
    • Han, X.1    Gross, R.W.2
  • 3
    • 22144478635 scopus 로고    scopus 로고
    • The emerging field of lipidomics
    • DOI 10.1038/nrd1776
    • M.R. Wenk The emerging field of lipidomics Nat. Rev. Drug Discov. 4 2005 594 610 (Pubitemid 40975712)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.7 , pp. 594-610
    • Wenk, M.R.1
  • 4
    • 0019162068 scopus 로고
    • The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters
    • M.S. Brown, Y.K. Ho, and J.L. Goldstein The cholesteryl ester cycle in macrophage foam cells: continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters J. Biol. Chem. 255 1980 9344 9352 (Pubitemid 11202897)
    • (1980) Journal of Biological Chemistry , vol.255 , Issue.19 , pp. 9344-9352
    • Brown, M.S.1    Ho, Y.K.2    Goldstein, J.L.3
  • 5
    • 1542273633 scopus 로고    scopus 로고
    • Dietary Diacylglycerol Prevents High-Fat Diet-Induced Lipid Accumulation in Rat Liver and Abdominal Adipose Tissue
    • DOI 10.1007/s11745-004-1199-1
    • X. Meng, D. Zou, Z. Shi, Z. Duan, and Z. Mao Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue Lipids 39 2004 37 41 (Pubitemid 38296125)
    • (2004) Lipids , vol.39 , Issue.1 , pp. 37-41
    • Meng, X.1    Zou, D.2    Shi, Z.3    Duan, Z.4    Mao, Z.5
  • 7
    • 0030760711 scopus 로고    scopus 로고
    • Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions
    • T.R. Pettitt, A. Martin, T. Horton, C. Liossis, J.M. Lord, and M.J.O. Wakelam Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions J. Biol. Chem. 272 1997 17354 17359
    • (1997) J. Biol. Chem. , vol.272 , pp. 17354-17359
    • Pettitt, T.R.1    Martin, A.2    Horton, T.3    Liossis, C.4    Lord, J.M.5    Wakelam, M.J.O.6
  • 8
    • 0031057288 scopus 로고    scopus 로고
    • Lipid biochemistry: Functions of glycerolipids and sphingolipids in cellular signaling
    • S. Ghosh, J.C. Strum, and R.M. Bell Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling FASEB J. 11 1997 45 50 (Pubitemid 27076323)
    • (1997) FASEB Journal , vol.11 , Issue.1 , pp. 45-50
    • Ghosh, S.1    Strum, J.C.2    Bell, R.M.3
  • 9
    • 0035204169 scopus 로고    scopus 로고
    • Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C
    • DOI 10.1096/fj.01-0753int
    • S. Madani, A. Hichami, A. Legrand, J. Belleville, and N.A. Khan Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C FASEB J. 15 2001 2595 2601 (Pubitemid 33131086)
    • (2001) FASEB Journal , vol.15 , Issue.14 , pp. 2595-2601
    • Madani, S.1    Hichami, A.2    Legrand, A.3    Belleville, J.4    Khan, N.A.5
  • 10
    • 0033781544 scopus 로고    scopus 로고
    • Protein kinase C activation and its pharmacological inhibition in vascular disease
    • M. Meier, and G.L. King Protein kinase C activation and its pharmacological inhibition in vascular disease Vasc. Med. 5 2000 173 185
    • (2000) Vasc. Med. , vol.5 , pp. 173-185
    • Meier, M.1    King, G.L.2
  • 11
    • 33847200444 scopus 로고    scopus 로고
    • Quantification of diacylglycerol molecular species in biological samples by electrospray ionization mass spectrometry after one-step derivatization
    • Y.L. Li, X. Su, P.D. Stahl, and M.L. Gross Quantification of diacylglycerol molecular species in biological samples by electrospray ionization mass spectrometry after one-step derivatization Anal. Chem. 79 2007 1569 1574
    • (2007) Anal. Chem. , vol.79 , pp. 1569-1574
    • Li, Y.L.1    Su, X.2    Stahl, P.D.3    Gross, M.L.4
  • 12
    • 4544331579 scopus 로고    scopus 로고
    • Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans
    • DOI 10.1194/jlr.M300511-JLR200
    • C.C. Schwartz, J.M. VandenBroek, and P.S. Cooper Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans J. Lipid Res. 45 2004 1594 1607 (Pubitemid 39296198)
    • (2004) Journal of Lipid Research , vol.45 , Issue.9 , pp. 1594-1607
    • Schwartz, C.C.1    VandenBroek, J.M.2    Cooper, P.S.3
  • 13
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • DOI 10.1016/S0092-8674(00)80213-5
    • M.S. Brown, and J.L. Goldstein The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 1997 331 340 (Pubitemid 27220877)
    • (1997) Cell , vol.89 , Issue.3 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 14
    • 0024537390 scopus 로고
    • Distribution and functions of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. Evidence for a functional unit containing these activities together with apolipoproteins A-1 and D that catalyzes the esterification and transfer of cell-derived cholesterol
    • O.L. Francone, A. Gurakar, and C. Fielding Distribution and functions of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins: evidence for a functional unit containing these activities together with apolipoproteins A-I and D that catalyzes the esterification and transfer of cell-derived cholesterol J. Biol. Chem. 264 1989 7066 7072 (Pubitemid 19114827)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.12 , pp. 7066-7072
    • Francone, O.L.1    Gurakar, A.2    Fielding, C.3
  • 15
    • 0022256566 scopus 로고
    • Role of acyl-CoA:cholesterol acyltransferase in cellular cholesterol metabolism
    • K.E. Suckling, and E.F. Stange Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism J. Lipid Res. 26 1985 647 671 (Pubitemid 15248938)
    • (1985) Journal of Lipid Research , vol.26 , Issue.6 , pp. 647-671
    • Suckling, K.E.1    Stange, E.F.2
  • 16
    • 0016293419 scopus 로고
    • Cholesteryl ester synthesis in normal and atherosclerotic aortas of rabbits and rhesus monkeys
    • P.I. Brecher, and A.V. Chobanian Cholesteryl ester synthesis in normal and atherosclerotic aortas of rabbits and rhesus monkeys Circ. Res. 35 1974 692 701
    • (1974) Circ. Res. , vol.35 , pp. 692-701
    • Brecher, P.I.1    Chobanian, A.V.2
  • 17
    • 44849094277 scopus 로고    scopus 로고
    • Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein
    • R. Harkewicz, K. Hartvigsen, F. Almazan, E.A. Dennis, J.L. Witztum, and Y.I. Miller Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein J. Biol. Chem. 283 2008 10241 10251
    • (2008) J. Biol. Chem. , vol.283 , pp. 10241-10251
    • Harkewicz, R.1    Hartvigsen, K.2    Almazan, F.3    Dennis, E.A.4    Witztum, J.L.5    Miller, Y.I.6
  • 20
    • 0030916820 scopus 로고    scopus 로고
    • Fatty acids in serum cholesteryl esters as quantitative biomarkers of dietary intake in humans
    • P.L. Zock, R.P. Mensink, J. Harryvan, J.H.M. de Vries, and M.B. Katan Fatty acids in serum cholesteryl esters as quantitative biomarkers of dietary intake in humans Am. J. Epidemiol. 145 1997 1114 1122 (Pubitemid 27272941)
    • (1997) American Journal of Epidemiology , vol.145 , Issue.12 , pp. 1114-1122
    • Zock, P.L.1    Mensink, R.P.2    Harryvan, J.3    De Vries, J.H.M.4    Katan, M.B.5
  • 21
    • 0035241693 scopus 로고    scopus 로고
    • Analysis of nonvolatile lipids by mass spectrometry
    • DOI 10.1021/cr9900883
    • R.C. Murphy, J. Fiedler, and J. Hevko Analysis of nonvolatile lipids by mass spectrometry Chem. Rev. 101 2001 479 526 (Pubitemid 32325802)
    • (2001) Chemical Reviews , vol.101 , Issue.2 , pp. 479-526
    • Murphy, R.C.1    Fiedler, J.2    Hevko, J.3
  • 22
    • 0029866839 scopus 로고    scopus 로고
    • Quantitation of 1-stearoyl-2-arachidonoyl-sn-3-glycerol in human basophils via gas chromatography-negative ion chemical ionization mass spectrometry
    • W.C. Hubbard, T.R. Hundley, A. Oriente, and J.D.W. MacGlashan Quantitation of 1-stearoyl-2-arachidonoyl-sn-3-glycerol in human basophils via gas chromatography-negative ion chemical ionization mass spectrometry Anal. Biochem. 236 1996 309 321
    • (1996) Anal. Biochem. , vol.236 , pp. 309-321
    • Hubbard, W.C.1    Hundley, T.R.2    Oriente, A.3    MacGlashan, J.D.W.4
  • 24
    • 0242690342 scopus 로고    scopus 로고
    • Quantitation and molecular species determination of diacylglycerols, phosphatidylcholines, ceramides, and sphingomyelins with gas chromatography
    • DOI 10.1016/j.ab.2003.08.026
    • K.-Y. Tserng, and R. Griffin Quantitation and molecular species determination of diacylglycerols, phosphatidylcholines, ceramides, and sphingomyelins with gas chromatography Anal. Biochem. 323 2003 84 93 (Pubitemid 37393361)
    • (2003) Analytical Biochemistry , vol.323 , Issue.1 , pp. 84-93
    • Tserng, K.-Y.1    Griffin, R.2
  • 25
    • 0023299427 scopus 로고
    • Capillary gas chromatography/mass spectrometry of cholesteryl esters with negative ammonia chemical ionization
    • R.P. Evershed, and L.J. Goad Capillary gas chromatography/mass spectrometry of cholesteryl esters with negative ammonia chemical ionization Biol. Mass Spectrom. 14 1987 131 140
    • (1987) Biol. Mass Spectrom. , vol.14 , pp. 131-140
    • Evershed, R.P.1    Goad, L.J.2
  • 26
    • 0027399103 scopus 로고
    • Quantification of diacylglycerols by capillary gas chromatography- negative ion chemical ionization-mass spectrometry
    • DOI 10.1006/abio.1993.1052
    • P. Falardeau, M. Robillard, and R. Hui Quantification of diacylglycerols by capillary gas chromatography-negative ion chemical ionization-mass spectrometry Anal. Biochem. 208 1993 311 316 (Pubitemid 23084677)
    • (1993) Analytical Biochemistry , vol.208 , Issue.2 , pp. 311-316
    • Falardeau, P.1    Robillard, M.2    Hui, R.3
  • 27
    • 5444275263 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectrometry in lipid and phospholipid research
    • DOI 10.1016/j.plipres.2004.08.001, PII S0163782704000268
    • J. Schiller, R. Süß, J. Arnhold, B. Fuchs, J. Leßig, M. Müller, M. Petkovic, H. Spalteholz, O. Zschörnig, and K. Arnold Matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectrometry in lipid and phospholipid research Prog. Lipid Res. 43 2004 449 488 (Pubitemid 39359134)
    • (2004) Progress in Lipid Research , vol.43 , Issue.5 , pp. 449-488
    • Schiller, J.1    Suss, R.2    Arnhold, J.3    Fuchs, B.4    Lessig, J.5    Muller, M.6    Petkovic, M.7    Spalteholz, H.8    Zschornig, O.9    Arnold, K.10
  • 28
    • 44949247591 scopus 로고    scopus 로고
    • Separation of cellular nonpolar neutral lipids by normal-phase chromatography and analysis by electrospray ionization mass spectrometry
    • P.M. Hutchins, R.M. Barkley, and R.C. Murphy Separation of cellular nonpolar neutral lipids by normal-phase chromatography and analysis by electrospray ionization mass spectrometry J. Lipid Res. 49 2008 804 813
    • (2008) J. Lipid Res. , vol.49 , pp. 804-813
    • Hutchins, P.M.1    Barkley, R.M.2    Murphy, R.C.3
  • 29
    • 33646048311 scopus 로고    scopus 로고
    • High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS)
    • G. Liebisch, M. Binder, R. Schifferer, T. Langmann, B. Schulz, and G. Schmitz High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS) Biochim. Biophys. Acta 1761 2006 121 128
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 121-128
    • Liebisch, G.1    Binder, M.2    Schifferer, R.3    Langmann, T.4    Schulz, B.5    Schmitz, G.6
  • 30
    • 34249005002 scopus 로고    scopus 로고
    • Detection of the abundance of diacylglycerol and triacylglycerol molecular species in cells using neutral loss mass spectrometry
    • DOI 10.1016/j.ab.2007.03.012, PII S0003269707001613
    • R.C. Murphy, P.F. James, A.M. McAnoy, J. Krank, E. Duchoslav, and R.M. Barkley Detection of the abundance of diacylglycerol and triacylglycerol molecular species in cells using neutral loss mass spectrometry Anal. Biochem. 366 2007 59 70 (Pubitemid 46779007)
    • (2007) Analytical Biochemistry , vol.366 , Issue.1 , pp. 59-70
    • Murphy, R.C.1    James, P.F.2    McAnoy, A.M.3    Krank, J.4    Duchoslav, E.5    Barkley, R.M.6
  • 31
    • 0026213291 scopus 로고
    • Electrospray and tandem mass spectrometric characterization of acylglycerol mixtures that are dissolved in nonpolar solvents
    • K.L. Duffin, J.D. Henion, and J.J. Shieh Electrospray and tandem mass spectrometric characterization of acylglycerol mixtures that are dissolved in nonpolar solvents Anal. Chem. 63 1991 1781 1788
    • (1991) Anal. Chem. , vol.63 , pp. 1781-1788
    • Duffin, K.L.1    Henion, J.D.2    Shieh, J.J.3
  • 32
    • 0035425057 scopus 로고    scopus 로고
    • Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry
    • DOI 10.1006/abio.2001.5178
    • X. Han, and R.W. Gross Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry Anal. Biochem. 295 2001 88 100 (Pubitemid 32721744)
    • (2001) Analytical Biochemistry , vol.295 , Issue.1 , pp. 88-100
    • Han, X.1    Gross, R.W.2
  • 33
    • 0033404418 scopus 로고    scopus 로고
    • Structural characterization of triacylglycerols as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisionally activated dissociation on a triple stage quadrupole instrument
    • DOI 10.1016/S1044-0305(99)00035-5, PII S1044030599000355
    • F.-F. Hsu, and J. Turk Structural characterization of triacylglycerols as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisionally activated dissociation on a triple stage quadrupole instrument J. Am. Soc. Mass Spectrom. 10 1999 587 599 (Pubitemid 34475125)
    • (1999) Journal of the American Society for Mass Spectrometry , vol.10 , Issue.7 , pp. 587-599
    • Hsu, F.-F.1    Turk, J.2
  • 34
    • 0032232019 scopus 로고    scopus 로고
    • Formation of lithiated adducts of glycerophosphocholine lipids facilitates their identification by electrospray ionization tandem mass spectrometry
    • F.F. Hsu, A. Bohrer, and J. Turk Formation of lithiated adducts of glycerophosphocholine lipids facilitates their identification by electrospray ionization tandem mass spectrometry J. Am. Soc. Mass Spectrom. 9 1998 516 526
    • (1998) J. Am. Soc. Mass Spectrom. , vol.9 , pp. 516-526
    • Hsu, F.F.1    Bohrer, A.2    Turk, J.3
  • 35
    • 0025287249 scopus 로고
    • Differential metabolism of diradyl glycerol molecular subclasses and molecular species by rabbit brain diglyceride kinase
    • D.A. Ford, and R.W. Gross Differential metabolism of diradyl glycerol molecular subclasses and molecular species by rabbit brain diglyceride kinase J. Biol. Chem. 265 1990 12280 12286
    • (1990) J. Biol. Chem. , vol.265 , pp. 12280-12286
    • Ford, D.A.1    Gross, R.W.2
  • 36
    • 0035805629 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    • L.L. Listenberger, D.S. Ory, and J.E. Schaffer Palmitate-induced apoptosis can occur through a ceramide-independent pathway J. Biol. Chem. 276 2001 14890 14895
    • (2001) J. Biol. Chem. , vol.276 , pp. 14890-14895
    • Listenberger, L.L.1    Ory, D.S.2    Schaffer, J.E.3
  • 37
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • E.G. Bligh, and W.J. Dyer A rapid method of total lipid extraction and purification Can. J. Biochem. Physiol. 37 1959 911 917
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 38
    • 0034653610 scopus 로고    scopus 로고
    • Electrospray/tandem mass spectrometry for quantitative analysis of lipid remodeling in essential fatty acid deficient mice
    • DOI 10.1006/abio.1999.4452
    • K. Duffin, M. Obukowicz, A. Raz, and J.J. Shieh Electrospray/tandem mass spectrometry for quantitative analysis of lipid remodeling in essential fatty acid deficient mice Anal. Biochem. 279 2000 179 188 (Pubitemid 30165006)
    • (2000) Analytical Biochemistry , vol.279 , Issue.2 , pp. 179-188
    • Duffin, K.1    Obukowicz, M.2    Raz, A.3    Shieh, J.J.4
  • 39
    • 0035940711 scopus 로고    scopus 로고
    • Analysis of free and esterified sterols in fats and oils by flash chromatography, gas chromatography and electrospray tandem mass spectrometry
    • DOI 10.1016/S0021-9673(01)01315-2, PII S0021967301013152
    • P. Kalo, and T. Kuuranne Analysis of free and esterified sterols in fats and oils by flash chromatography, gas chromatography, and electrospray tandem mass spectrometry J. Chromatogr. A 935 2001 237 248 (Pubitemid 33044648)
    • (2001) Journal of Chromatography A , vol.935 , Issue.1-2 , pp. 237-248
    • Kalo, P.1    Kuuranne, T.2
  • 41
    • 0016666155 scopus 로고
    • Substrate-selectivity of rat liver microsomal 1,2-diacylglycerol:CDP- choline(ethanolamine) choline(ethanolamine)phosphotransferase in utilizing endogenous substrates
    • H. Kanoh, and K. Ohno Substrate-selectivity of rat liver microsomal 1,2-diacylglycerol:CDP-choline(ethanolamine) choline(ethanolamine) phosphotransferase in utilizing endogenous substrates Biochim. Biophys. Acta 380 1975 199 207
    • (1975) Biochim. Biophys. Acta , vol.380 , pp. 199-207
    • Kanoh, H.1    Ohno, K.2
  • 42
    • 0023646006 scopus 로고
    • Diacylglycerol metabolism in mast cells: Analysis of lipid metabolic pathways using molecular species analysis of intermediates
    • D.A. Kennerly Diacylglycerol metabolism in mast cells: analysis of lipid metabolic pathways using molecular species analysis of intermediates J. Biol. Chem. 262 1987 16305 16313
    • (1987) J. Biol. Chem. , vol.262 , pp. 16305-16313
    • Kennerly, D.A.1
  • 43
    • 0029060391 scopus 로고
    • Protein kinase C and lipid signaling for sustained cellular responses
    • Y. Nishizuka Protein kinase C and lipid signaling for sustained cellular responses FASEB J. 9 1995 484 496
    • (1995) FASEB J. , vol.9 , pp. 484-496
    • Nishizuka, Y.1
  • 44
    • 29644445908 scopus 로고    scopus 로고
    • Electrospray ionization mass spectrometry of regioisomeric 1,2-diacylglycerols
    • DOI 10.2116/bunsekikagaku.54.807
    • T. Hashidate, and Y. Itabashi Electrospray ionization mass spectrometry of regioisomeric 1,2-diacylglycerols Bunseki Kagaku 54 2005 807 816 (Pubitemid 43020901)
    • (2005) Bunseki Kagaku , vol.54 , Issue.9 , pp. 807-816
    • Hashidate, T.1    Itabashi, Y.2
  • 45
    • 33845512965 scopus 로고    scopus 로고
    • Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-κB activation
    • DOI 10.2337/db06-0188
    • K. Staiger, H. Staiger, C. Weigert, C. Haas, H.-U. Häring, and M. Kellerer Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-κB activation Diabetes 55 2006 3121 3126 (Pubitemid 44923651)
    • (2006) Diabetes , vol.55 , Issue.11 , pp. 3121-3126
    • Staiger, K.1    Staiger, H.2    Weigert, C.3    Haas, C.4    Haring, H.-U.5    Kellerer, M.6


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