Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice

Diabetologia

Volumn 58, Issue 8, 2015, Pages 1949-1958

  Zheng, Dong ^a,b,c   Ma, Jian ^b,c   Yu, Yong ^d   Li, Minghui ^d   Ni, Rui ^b,c   Wang, Grace ^c   Chen, Ruizhen ^d   Li, Jianmin ^e   Fan, Guo Chang ^f   Lacefield, James C ^g   Peng, Tianqing ^a,b,c  

^a SOOCHOW UNIVERSITY   (China)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

^e THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^f UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^g ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Angiogenesis; Apoptosis; Cardiomyopathy; Diabetes; Hypertrophy; miR 195; Myocardial dysfunction

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CREATININE; ELASTIN; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; MESSENGER RNA; MICRORNA; MICRORNA 15A; MICRORNA 195; PROTEIN BCL 2; SIRTUIN 1; STREPTOZOCIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BCL2 PROTEIN, MOUSE; MIRN195 MICRORNA, MOUSE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CAPILLARY DENSITY; CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CREATININE BLOOD LEVEL; DIABETIC CARDIOMYOPATHY; ENZYME ACTIVITY; GENE EXPRESSION; GENE SILENCING; HEART FUNCTION; HEART MUSCLE CAPILLARY; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SENSITIVITY; KIDNEY FUNCTION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UPREGULATION; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM;

ANIMALS; CASPASE 3; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; GENE SILENCING; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIRTUIN 1;

EID: 84937524134     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3622-8     Document Type: Article

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