MicroRNA-133a regulates DNA methylation in diabetic cardiomyocytes

Biochemical and Biophysical Research Communications

Volumn 425, Issue 3, 2012, Pages 668-672

  Chavali, Vishalakshi ^a   Tyagi, Suresh C ^a   Mishra, Paras K ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Dnmt 1; Dnmt 3; Epi miRNA; Epigenetic modification; HL1 cardiomyocytes

Indexed keywords

DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; MICRORNA; MICRORNA 133A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION; HEART MUSCLE CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; INSULIN; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; MYOCYTES, CARDIAC;

MUS;

EID: 84865565944     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.105     Document Type: Article

References (34)

1. Basu R., Oudit G.Y., Wang X., Zhang L., Ussher J.R., Lopaschuk G.D., Kassiri Z. Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. Am. J. Physiol Heart Circ. Physiol. 2009, 297:H2096-H2108.
2. Benetti R., Gonzalo S., Jaco I., Munoz P., Gonzalez S., Schoeftner S., Murchison E., Andl T., Chen T., Klatt P., Li E., Serrano M., Millar S., Hannon G., Blasco M.A. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat. Struct. Mol. Biol. 2008, 15:268-279.
3. Brasacchio D., Okabe J., Tikellis C., Balcerczyk A., George P., Baker E.K., Calkin A.C., Brownlee M., Cooper M.E., El-Osta A. Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes 2009, 58:1229-1236.
4. Care A., Catalucci D., Felicetti F., Bonci D., Addario A., Gallo P., Bang M.L., Segnalini P., Gu Y., Dalton N.D., Elia L., Latronico M.V., Hoydal M., Autore C., Russo M.A., Dorn G.W., Ellingsen O., Ruiz-Lozano P., Peterson K.L., Croce C.M., Peschle C., Condorelli G. MicroRNA-133 controls cardiac hypertrophy. Nat. Med. 2007, 13:613-618.
5. Claycomb W.C., Lanson N.A., Stallworth B.S., Egeland D.B., Delcarpio J.B., Bahinski A., Izzo N.J. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc. Natl. Acad. Sci. USA 1998, 95:2979-2984.
6. Dhe-Paganon S., Syeda F., Park L. DNA methyl transferase 1: regulatory mechanisms and implications in health and disease. Int. J. Biochem. Mol. Biol. 2011, 2:58-66.
7. Fabbri M., Garzon R., Cimmino A., Liu Z., Zanesi N., Callegari E., Liu S., Alder H., Costinean S., Fernandez-Cymering C., Volinia S., Guler G., Morrison C.D., Chan K.K., Marcucci G., Calin G.A., Huebner K., Croce C.M. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. USA 2007, 104:15805-15810.
8. Feng B., Chen S., George B., Feng Q., Chakrabarti S. MiR133a regulates cardiomyocyte hypertrophy in diabetes. Diabetes Metab Res. Rev. 2010, 26:40-49.
9. Garin I., Edghill E.L., Akerman I., Rubio-Cabezas O., Rica I., Locke J.M., Maestro M.A., Alshaikh A., Bundak R., del C.G., Deeb A., Deiss D., Fernandez J.M., Godbole K., Hussain K., O'Connell M., Klupa T., Kolouskova S., Mohsin F., Perlman K., Sumnik Z., Rial J.M., Ugarte E., Vasanthi T., Johnstone K., Flanagan S.E., Martinez R., Castano C., Patch A.M., Fernandez-Rebollo E., Raile K., Morgan N., Harries L.W., Castano L., Ellard S., Ferrer J., Perez de N.G., Hattersley A.T. Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. Proc. Natl. Acad. Sci. USA 2010, 107:3105-3110.
10. Garin I., Perez de N.G., Gastaldo E., Harries L.W., Rubio-Cabezas O., Castano L. Permanent neonatal diabetes caused by creation of an ectopic splice site within the INS gene. PLoS One 2012, 7:e29205.
11. Guay C., Roggli E., Nesca V., Jacovetti C., Regazzi R. Diabetes mellitus, a microRNA-related disease?. Transl. Res. 2011, 157:253-264.
12. Handel A.E., Ebers G.C., Ramagopalan S.V. Epigenetics: molecular mechanisms and implications for disease. Trends Mol. Med. 2010, 16:7-16.
13. Iorio M.V., Piovan C., Croce C.M. Interplay between microRNAs and the epigenetic machinery: an intricate network. Biochim. Biophys. Acta 2010, 1799:694-701.
14. Karagiannis T.C., Maulik N. Factors influencing epigenetic mechanisms and related diseases. Antioxid. Redox. Signal. 2012, 17:192-194.
15. Khraiwesh B., Arif M.A., Seumel G.I., Ossowski S., Weigel D., Reski R., Frank W. Transcriptional control of gene expression by microRNAs. Cell 2010, 140:111-122.
16. King H., Aubert R.E., Herman W.H. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998, 21:1414-1431.
17. Mathew V., Gersh B.J., Williams B.A., Laskey W.K., Willerson J.T., Tilbury R.T., Davis B.R., Holmes D.R. Outcomes in patients with diabetes mellitus undergoing percutaneous coronary intervention in the current era: a report from the prevention of REStenosis with tranilast and its outcomes (PRESTO) trial. Circulation 2004, 109:476-480.
18. Matkovich S.J., Wang W., Tu Y., Eschenbacher W.H., Dorn L.E., Condorelli G., Diwan A., Nerbonne J.M., Dorn G.W. MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. Circ. Res. 2010, 106:166-175.
19. Mishra P.K., Givvimani S., Metreveli N., Tyagi S.C. Attenuation of beta2-adrenergic receptors and homocysteine metabolic enzymes cause diabetic cardiomyopathy. Biochem. Biophys. Res. Commun. 2010, 401:175-181.
20. Mishra P.K., Tyagi N., Kumar M., Tyagi S.C. MicroRNAs as a therapeutic target for cardiovascular diseases. J. Cell Mol. Med. 2009, 13:778-789.
21. Mishra P.K., Tyagi N., Kundu S., Tyagi S.C. MicroRNAs are involved in homocysteine-induced cardiac remodeling. Cell Biochem. Biophys. 2009, 55:153-162.
22. Nguyen T., Kuo C., Nicholl M.B., Sim M.S., Turner R.R., Morton D.L., Hoon D.S. Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma. Epigenetics 2011, 6:388-394.
23. Nikoshkov A., Sunkari V., Savu O., Forsberg E., Catrina S.B., Brismar K. Epigenetic DNA methylation in the promoters of the Igf1 receptor and insulin receptor genes in db/db mice. Epigenetics 2011, 6:405-409.
24. Okano M., Bell D.W., Haber D.A., Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99:247-257.
25. Pignone M., Alberts M.J., Colwell J.A., Cushman M., Inzucchi S.E., Mukherjee D., Rosenson R.S., Williams C.D., Wilson P.W., Kirkman M.S. Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation. Diabetes Care 2010, 33:1395-1402.
26. Sato F., Tsuchiya S., Meltzer S.J., Shimizu K. MicroRNAs and epigenetics. FEBS J. 2011, 278:1598-1609.
27. Sinkkonen L., Hugenschmidt T., Berninger P., Gaidatzis D., Mohn F., Artus-Revel C.G., Zavolan M., Svoboda P., Filipowicz W. MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat. Struct. Mol. Biol. 2008, 15:259-267.
28. Temiz N.A., Donohue D.E., Bacolla A., Luke B.T., Collins J.R. The role of methylation in the intrinsic dynamics of B- and Z-DNA. PLoS One 2012, 7:e35558.
29. Wang Y.S., Chou W.W., Chen K.C., Cheng H.Y., Lin R.T., Juo S.H. MicroRNA-152 mediates DNMT1-regulated DNA methylation in the estrogen receptor alpha gene. PLoS One 2012, 7:e30635.
30. White S.M., Constantin P.E., Claycomb W.C. Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function. Am. J. Physiol Heart Circ. Physiol 2004, 286:H823-H829.
31. + channel expression contributing to QT prolongation in diabetic hearts. J. Biol. Chem. 2007, 282:12363-12367.
32. Xiao Y., Word B., Starlard-Davenport A., Haefele A., Lyn-Cook B.D., Hammons G. Age and gender affect DNMT3a and DNMT3b expression in human liver. Cell Biol. Toxicol. 2008, 24:265-272.
33. Zou X., Ma W., Solov'yov I.A., Chipot C., Schulten K. Recognition of methylated DNA through methyl-CpG binding domain proteins. Nucleic Acids Res. 2012, 40:2747-2758.
34. Tyagi A.C., Sen U., Mishra P.K. Synergy of micro RNA and stem cell: a novel therapeutic approach for diabetes mellitus and cardiovascular discases. Curr. Diabetes Rev. 2011, 7:367-376.