Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA

Journal of Medicinal Chemistry

Volumn 58, Issue 13, 2015, Pages 5208-5217

  Dai, Ran ^a   Geders, Todd W ^a   Liu, Feng ^a   Park, Sae Woong ^b   Schnappinger, Dirk ^b   Aldrich, Courtney C ^a   Finzel, Barry C ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; BIOA PROTEIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BIOA PROTEIN, BACTERIA; MOLECULAR LIBRARY;

ARTICLE; BINDING SITE; BIOSYNTHESIS; CALORIMETRY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DIFFERENTIAL SCANNING FLUORIMETRY; ENTHALPY; FLUOROMETRY; MOLECULAR DYNAMICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN CONFORMATION; SCREENING; THERMODYNAMICS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFECTS; ENZYME ACTIVE SITE; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; TUBERCULOSIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CALORIMETRY, DIFFERENTIAL SCANNING; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; SMALL MOLECULE LIBRARIES; THERMODYNAMICS; TRANSAMINASES; TUBERCULOSIS;

EID: 84937510652     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00092     Document Type: Article

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