Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics

ACS Chemical Biology

Volumn 10, Issue 7, 2015, Pages 1667-1675

  Peterson Kaufman, Kimberly J ^a   Haase, Holly S ^a   Boersma, Melissa D ^a   Lee, Erinna F ^b,c   Fairlie, W Douglas ^b,c   Gellman, Samuel H ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO ACID; BETA AMINO ACID; BH3 PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; BAX PROTEIN (53-86); CYCLOPEPTIDE; ONCOPROTEIN; PEPTIDE FRAGMENT; PROTEIN BCL X; PROTEIN BINDING;

ALPHA HELIX; ANIMAL CELL; APOPTOSIS; ARTICLE; CIRCULAR DICHROISM; COMPLEX FORMATION; CRYSTAL STRUCTURE; FIBROBLAST; HYDROPHOBICITY; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SOLID PHASE SYNTHESIS; SURFACE PLASMON RESONANCE; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR DOCKING; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BCL-X PROTEIN; CELL LINE; HUMANS; MICE; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS;

EID: 84937148790     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00109     Document Type: Article

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