5-HT2C serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice

Pharmacological Research

Volumn 99, Issue , 2015, Pages 258-268

  Busceti, Carla Letizia ^a   Pietro, Paola Di ^a   Riozzi, Barbara ^a   Traficante, Anna ^a   Biagioni, Francesca ^a   Nisticò, Robert ^b,c   Fornai, Francesco ^a,d   Battaglia, Giuseppe ^a   Nicoletti, Ferdinando ^a,b   Bruno, Valeria ^a,b  

^a IRCCS NEUROMED   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

MDMA; Memory retrival; Serotonin; Synaptic plasticity; Tau protein

Indexed keywords

8 [5 [2,4 DIMETHOXY 5 (4 TRIFLUOROMETHYLPHENYLSULFONAMIDO)PHENYL] 5 OXOPENTYL] 1,3,8 TRIAZASPIRO[4.5]DECANE 2,4 DIONE; SEROTONIN 2C RECEPTOR; TAU PROTEIN; SEROTONIN 2 ANTAGONIST;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLIOSIS; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; MEMORY DISORDER; MOUSE; NERVE CELL PLASTICITY; NEUROPROTECTION; NOISE; NONHUMAN; PHYSICAL STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENSORY STIMULATION; SPATIAL MEMORY; ANIMAL; C57BL MOUSE; DRUG EFFECTS; MEMORY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; SYNAPTIC TRANSMISSION;

ANIMALS; FEMALE; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MEMORY; MICE; MICE, INBRED C57BL; NEURONAL PLASTICITY; PHOSPHORYLATION; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS; STRESS, PHYSIOLOGICAL; SYNAPTIC TRANSMISSION; TAU PROTEINS;

EID: 84937109121     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.06.017     Document Type: Article

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