메뉴 건너뛰기




Volumn 18, Issue 13, 1998, Pages 5086-5094

Small changes in ambient temperature cause large changes in 3,4- methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat

Author keywords

5 HT; Ambient temperature; Amphetamine; Core body temperature; MDMA; Neurotoxicity; Thermoregulation

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 5 HYDROXYINDOLEACETIC ACID; SEROTONIN;

EID: 0032125256     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-13-05086.1998     Document Type: Article
Times cited : (293)

References (66)
  • 1
    • 0344652106 scopus 로고    scopus 로고
    • High and low doses of 3,4-methylenedioxymethamphetamine (MDMA) impair thermoregulatory ability in the rat
    • Ainsworth AM, Malberg JE, Seiden LS (1997) High and low doses of 3,4-methylenedioxymethamphetamine (MDMA) impair thermoregulatory ability in the rat. Soc Neurosci Abstr 2:1352.
    • (1997) Soc Neurosci Abstr , vol.2 , pp. 1352
    • Ainsworth, A.M.1    Malberg, J.E.2    Seiden, L.S.3
  • 2
    • 0028100290 scopus 로고
    • Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice
    • Ali SF, Newport GD, Holson RR, Slikker Jr W, Bowyer JF (1994) Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice. Brain Res 658:33-38.
    • (1994) Brain Res , vol.658 , pp. 33-38
    • Ali, S.F.1    Newport, G.D.2    Holson, R.R.3    Slikker Jr, W.4    Bowyer, J.F.5
  • 3
    • 0027512329 scopus 로고
    • Ecstasy, the serotonin syndrome, and neuroleptic malignant syndrome-a possible link?
    • Ames D, Wirshing WC (1993) Ecstasy, the serotonin syndrome, and neuroleptic malignant syndrome-a possible link [letter]? JAMA 269:869-870.
    • (1993) JAMA , vol.269 , pp. 869-870
    • Ames, D.1    Wirshing, W.C.2
  • 4
    • 0024159060 scopus 로고
    • MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons
    • Battaglia G, Yeh SY, DeSouza EB (1988) MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons. Pharmacol Biochem Behav 29:269-274.
    • (1988) Pharmacol Biochem Behav , vol.29 , pp. 269-274
    • Battaglia, G.1    Yeh, S.Y.2    DeSouza, E.B.3
  • 5
    • 0026563868 scopus 로고
    • The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum
    • Bowyer JF, Tank AW, Newport GD, Slikker Jr W, Ali SF, Holson RR (1992) The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum. J Pharmacol Exp Ther 260:817-824.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 817-824
    • Bowyer, J.F.1    Tank, A.W.2    Newport, G.D.3    Slikker Jr, W.4    Ali, S.F.5    Holson, R.R.6
  • 6
    • 0027514433 scopus 로고
    • Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats
    • Bowyer JF, Gough B, Slikker Jr W, Lipe GW, Newport GD, Holson RR (1993) Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats. Pharmacol Biochem Behav 44:87-98.
    • (1993) Pharmacol Biochem Behav , vol.44 , pp. 87-98
    • Bowyer, J.F.1    Gough, B.2    Slikker Jr, W.3    Lipe, G.W.4    Newport, G.D.5    Holson, R.R.6
  • 9
    • 0028630595 scopus 로고
    • Involvement of oxygen-based radicals in methamphetamine-induced neurotoxicity: Evidence from the use of CuZnSOD transgenic mice
    • Cadet JL, Ali S, Epstein C (1994) Involvement of oxygen-based radicals in methamphetamine-induced neurotoxicity: evidence from the use of CuZnSOD transgenic mice. Ann NY Acad Sci 738:388-391.
    • (1994) Ann NY Acad Sci , vol.738 , pp. 388-391
    • Cadet, J.L.1    Ali, S.2    Epstein, C.3
  • 10
    • 0025936317 scopus 로고
    • Hypothermia prevents the ischemia-induced translocations and inhibition of protein kinase C in the rat striatum
    • Cardell M, Boris-Moller F, Wieloch T (1991) Hypothermia prevents the ischemia-induced translocations and inhibition of protein kinase C in the rat striatum. J Neurochem 57:1814-1817.
    • (1991) J Neurochem , vol.57 , pp. 1814-1817
    • Cardell, M.1    Boris-Moller, F.2    Wieloch, T.3
  • 11
    • 0344652105 scopus 로고
    • Search for the neuronal circuitries and heurotransmitters involved in "positive" and "negative" schizophrenic symptomatology
    • Carlsson A (1993) Search for the neuronal circuitries and heurotransmitters involved in "positive" and "negative" schizophrenic symptomatology. Fidia Res Found Lect Ser 7.
    • (1993) Fidia Res Found Lect Ser , vol.7
    • Carlsson, A.1
  • 12
    • 0028895035 scopus 로고
    • Body temperature effect on methylenedioxymethamphetamine-induced acute decrease in tryptophan hydroxylase activity
    • Che S, Johnson M, Hanson GR, Gibb JW (1995) Body temperature effect on methylenedioxymethamphetamine-induced acute decrease in tryptophan hydroxylase activity. Eur J Pharmacol 293:447-453.
    • (1995) Eur J Pharmacol , vol.293 , pp. 447-453
    • Che, S.1    Johnson, M.2    Hanson, G.R.3    Gibb, J.W.4
  • 13
    • 0029824463 scopus 로고    scopus 로고
    • Individual differences in dopamine release but not rotational behavior correlate with extracellular amphetamine levels in caudate putamen in unlesioned rats
    • Clausing P, Bloom D, Newport GD, Holson RR, Slikker Jr W, Bowyer JF (1996) Individual differences in dopamine release but not rotational behavior correlate with extracellular amphetamine levels in caudate putamen in unlesioned rats. Psychopharmacology 127:187-194.
    • (1996) Psychopharmacology , vol.127 , pp. 187-194
    • Clausing, P.1    Bloom, D.2    Newport, G.D.3    Holson, R.R.4    Slikker Jr., W.5    Bowyer, J.F.6
  • 14
    • 0024598167 scopus 로고
    • Use of telemetry to record body temperature and activity in mice
    • Clement JG, Mills P, Brockway B (1989) Use of telemetry to record body temperature and activity in mice. J Pharmacol Methods 21:129-140.
    • (1989) J Pharmacol Methods , vol.21 , pp. 129-140
    • Clement, J.G.1    Mills, P.2    Brockway, B.3
  • 15
    • 0027462464 scopus 로고
    • 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine
    • Colado MI, Murray TK, Green AR (1993) 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine. Br J Pharmacol 108:583-589.
    • (1993) Br J Pharmacol , vol.108 , pp. 583-589
    • Colado, M.I.1    Murray, T.K.2    Green, A.R.3
  • 16
    • 0029112473 scopus 로고
    • The hyperthermic and neurotoxic effects of "Ecstasy" (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype
    • Colado MI, Williams JL, Green AR (1995) The hyperthermic and neurotoxic effects of "Ecstasy" (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. Br J Pharmacol 115:1281-1289.
    • (1995) Br J Pharmacol , vol.115 , pp. 1281-1289
    • Colado, M.I.1    Williams, J.L.2    Green, A.R.3
  • 17
    • 0023141541 scopus 로고
    • 5,6-Dihydroxytryptamine, a serotonergic neurotoxin is formed endogenously in the rat brain
    • Commins DL, Axt KJ, Vosmer G, Seiden LS (1987a) 5,6-Dihydroxytryptamine, a serotonergic neurotoxin is formed endogenously in the rat brain. Brain Res 403:7-14.
    • (1987) Brain Res , vol.403 , pp. 7-14
    • Commins, D.L.1    Axt, K.J.2    Vosmer, G.3    Seiden, L.S.4
  • 18
    • 0023255308 scopus 로고
    • Biochemical and histological evidence that meth- Ylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain
    • Commins DL, Vosmer G, Virus RM, Woolverton WL, Schuster CR, Seiden LS (1987b) Biochemical and histological evidence that meth- ylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain. J Pharmacol Exp Ther 241:338-345.
    • (1987) J Pharmacol Exp Ther , vol.241 , pp. 338-345
    • Commins, D.L.1    Vosmer, G.2    Virus, R.M.3    Woolverton, W.L.4    Schuster, C.R.5    Seiden, L.S.6
  • 19
    • 0025268452 scopus 로고
    • MK-801 reduced cerebral ischemic injury by inducing hypothermia
    • Corbett D, Evans S, Thomas C, Wang D, Jonas R A (1990) MK-801 reduced cerebral ischemic injury by inducing hypothermia. Brain Res 514:300-304.
    • (1990) Brain Res , vol.514 , pp. 300-304
    • Corbett, D.1    Evans, S.2    Thomas, C.3    Wang, D.4    Jonas, R.A.5
  • 20
    • 0028335838 scopus 로고
    • Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in rats
    • Dafters RI (1994) Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in rats. Psychopharmacology 114:505-508.
    • (1994) Psychopharmacology , vol.114 , pp. 505-508
    • Dafters, R.I.1
  • 21
    • 0028858685 scopus 로고
    • Hyperthermia following MDMA administration in rats: Effects of ambient temperature, water consumption and chronic dosing
    • Dafters RI (1995) Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption and chronic dosing. Physiol Behav 58:877-882.
    • (1995) Physiol Behav , vol.58 , pp. 877-882
    • Dafters, R.I.1
  • 22
    • 0029800149 scopus 로고    scopus 로고
    • MDMA induced hyperthermia: Report of a fatality and review of current therapy
    • Dar KJ, McBrien ME (1996) MDMA induced hyperthermia: report of a fatality and review of current therapy. Intensive Care Med 22: 995-996.
    • (1996) Intensive Care Med , vol.22 , pp. 995-996
    • Dar, K.J.1    McBrien, M.E.2
  • 23
    • 0027178135 scopus 로고
    • Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
    • Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH (1993) Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci 13:2651-2661.
    • (1993) J Neurosci , vol.13 , pp. 2651-2661
    • Dawson, V.L.1    Dawson, T.M.2    Bartley, D.A.3    Uhl, G.R.4    Snyder, S.H.5
  • 24
    • 0025108943 scopus 로고
    • Telemetric measurement of core temperature in pharmacological research: Validity and reliability
    • Dilsaver SC, Majchrzak MJ, Alessi NE (1990) Telemetric measurement of core temperature in pharmacological research: validity and reliability. Prog Neuro-Psychopharmacol Biol Psychiatry 14:591-596.
    • (1990) Prog Neuro-Psychopharmacol Biol Psychiatry , vol.14 , pp. 591-596
    • Dilsaver, S.C.1    Majchrzak, M.J.2    Alessi, N.E.3
  • 25
    • 0026637356 scopus 로고
    • Measurement of temperature in the rat by rectal probe and telemetry yields compatible results
    • Dilsaver SC, Overstreet DH, Peck JA (1992) Measurement of temperature in the rat by rectal probe and telemetry yields compatible results. Pharmacol Biochem Behav 42:549-552.
    • (1992) Pharmacol Biochem Behav , vol.42 , pp. 549-552
    • Dilsaver, S.C.1    Overstreet, D.H.2    Peck, J.A.3
  • 26
    • 0028833356 scopus 로고
    • Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS19755 and NBQX
    • Farfel GM, Seiden LS (1995a) Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS19755 and NBQX. J Pharmacol Exp Ther 272:860-867.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 860-867
    • Farfel, G.M.1    Seiden, L.S.2
  • 27
    • 0028835738 scopus 로고
    • Role of hypothermia in the mechanism of protection against serotonergic toxicity. II. Experiments with methamphetamine. p-chloroamphetamine, fenfluramine, dizocilpine and dextromethorphan
    • Farfel GM, Seiden LS (1995b) Role of hypothermia in the mechanism of protection against serotonergic toxicity. II. Experiments with methamphetamine. p-chloroamphetamine, fenfluramine, dizocilpine and dextromethorphan. J Pharmacol Exp Ther 272:868-875.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 868-875
    • Farfel, G.M.1    Seiden, L.S.2
  • 28
    • 0344652102 scopus 로고
    • Ecstasy, the serotonin syndrome, and malignant hyperthermia-a possible link?
    • Friedman R (1993) Ecstasy, the serotonin syndrome, and malignant hyperthermia-a possible link [reply to letter]? JAMA 269:269-270.
    • (1993) JAMA , vol.269 , pp. 269-270
    • Friedman, R.1
  • 30
    • 0029112937 scopus 로고
    • Detection of free radical activity during transient global ischemia and recirculation: Effects of intraischemic brain temperature modulation
    • Globus MY, Busto R, Lin B, Schnippering H, Ginsberg MD (1995) Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem 65:1250-1256.
    • (1995) J Neurochem , vol.65 , pp. 1250-1256
    • Globus, M.Y.1    Busto, R.2    Lin, B.3    Schnippering, H.4    Ginsberg, M.D.5
  • 32
    • 0028199967 scopus 로고
    • Metabolic and thermoregulatory responses of the rat maintained in acrylic or wire-screen cages: Implications for pharmacological studies
    • Gordon CJ, Fogelson L (1994) Metabolic and thermoregulatory responses of the rat maintained in acrylic or wire-screen cages: implications for pharmacological studies. Physiol Behav 56:73-79.
    • (1994) Physiol Behav , vol.56 , pp. 73-79
    • Gordon, C.J.1    Fogelson, L.2
  • 33
    • 0026081849 scopus 로고
    • Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat
    • Gordon CJ, Watkinson WP. O'Callaghan JP, Miller DB (1991) Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat. Pharmacol Biochem Behav 38:339-344.
    • (1991) Pharmacol Biochem Behav , vol.38 , pp. 339-344
    • Gordon, C.J.1    Watkinson, W.P.2    O'Callaghan, J.P.3    Miller, D.B.4
  • 34
    • 0029067178 scopus 로고
    • Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy")
    • Green AR, Cross AJ, Goodwin GM (1995) Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy"). Psychopharmacology 119:247-260.
    • (1995) Psychopharmacology , vol.119 , pp. 247-260
    • Green, A.R.1    Cross, A.J.2    Goodwin, G.M.3
  • 35
    • 0030481579 scopus 로고    scopus 로고
    • Effect of ascorbate and cysteine on the 3,4-methylenedioxymethamphetamine-induced depletion of brain serotonin
    • Gudelsky GA (1996) Effect of ascorbate and cysteine on the 3,4-methylenedioxymethamphetamine-induced depletion of brain serotonin. J Neural Transm 103:1397-1404.
    • (1996) J Neural Transm , vol.103 , pp. 1397-1404
    • Gudelsky, G.A.1
  • 36
    • 0026754574 scopus 로고
    • Reactive oxygen species and the central nervous system
    • Halliwell B (1992) Reactive oxygen species and the central nervous system. J Neurochem 59:1609-1623.
    • (1992) J Neurochem , vol.59 , pp. 1609-1623
    • Halliwell, B.1
  • 37
    • 0026680529 scopus 로고
    • Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")
    • Henry JA (1992) Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy"). Lancet 340:384-387.
    • (1992) Lancet , vol.340 , pp. 384-387
    • Henry, J.A.1
  • 38
    • 0027953655 scopus 로고
    • Effects of hypothermia or anesthetics on hippocampal glutamate and glycine concentrations after repeated transient global cerebral ischemia
    • Illievich UM, Zornow MH, Choi KT, Strnat MA, Sehcller MS (1994) Effects of hypothermia or anesthetics on hippocampal glutamate and glycine concentrations after repeated transient global cerebral ischemia. Anesthesiology 80:177-186.
    • (1994) Anesthesiology , vol.80 , pp. 177-186
    • Illievich, U.M.1    Zornow, M.H.2    Choi, K.T.3    Strnat, M.A.4    Sehcller, M.S.5
  • 39
    • 0026535353 scopus 로고
    • Possible interaction between an MAOI and "Ecstasy."
    • Kaskey GB (1992) Possible interaction between an MAOI and "Ecstasy." Am J Psychiatry 149:411-412.
    • (1992) Am J Psychiatry , vol.149 , pp. 411-412
    • Kaskey, G.B.1
  • 40
    • 0003110629 scopus 로고    scopus 로고
    • Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats
    • Kil HY, Zhang J, Piantadosi CA (1996) Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats. J Cereb Blood Flow Metab 16:100-106.
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 100-106
    • Kil, H.Y.1    Zhang, J.2    Piantadosi, C.A.3
  • 41
    • 0021959927 scopus 로고
    • Determination of dopamine, norepinephrine, serotonin and their major metabolic products in rat brain by reverse phase ion pair high performance liquid chromatography with electrochemical detection
    • Kotake C, Heffner T, Vosmer G, Seiden LS (1985) Determination of dopamine, norepinephrine, serotonin and their major metabolic products in rat brain by reverse phase ion pair high performance liquid chromatography with electrochemical detection. Pharmacol Biochem Behav 22:85-89.
    • (1985) Pharmacol Biochem Behav , vol.22 , pp. 85-89
    • Kotake, C.1    Heffner, T.2    Vosmer, G.3    Seiden, L.S.4
  • 42
    • 0029013304 scopus 로고
    • 3,4-methylenedioxymethamphetamine ("Ecstasy") promotes the translocation of protein kinase C (PKC): Requirement of viable serotonin nerve terminals
    • Kramer HK, Poblete JC, Azmitia EC (1995) 3,4-methylenedioxymethamphetamine ("Ecstasy") promotes the translocation of protein kinase C (PKC): requirement of viable serotonin nerve terminals. Brain Res 680:1-8.
    • (1995) Brain Res , vol.680 , pp. 1-8
    • Kramer, H.K.1    Poblete, J.C.2    Azmitia, E.C.3
  • 43
    • 0030841975 scopus 로고    scopus 로고
    • Activation of protein kinase C (PKC) by 3,4-methylenudioxymelhamphetamine (MDMA) occurs through the stimulation of serotonin receptors and transporter
    • Kramer HK, Poblete JC, Azmitia EC (1997) Activation of protein kinase C (PKC) by 3,4-methylenudioxymelhamphetamine (MDMA) occurs through the stimulation of serotonin receptors and transporter. Neuropsychophannacology 17:117-129.
    • (1997) Neuropsychophannacology , vol.17 , pp. 117-129
    • Kramer, H.K.1    Poblete, J.C.2    Azmitia, E.C.3
  • 44
    • 0030087725 scopus 로고    scopus 로고
    • Methylenedioxymethamphetamine (MDMA)-induced serotonin deficits are followed by partial recovery over a 52 week period. II. Radio-ligand binding and autoradiographic studies
    • Lew R, Sabol KE, Chou C, Vosmer GL, Richards J, Seiden LS (1996) Methylenedioxymethamphetamine (MDMA)-induced serotonin deficits are followed by partial recovery over a 52 week period. II. Radio-ligand binding and autoradiographic studies. J Pharmacol Exp Ther 276:855-865.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 855-865
    • Lew, R.1    Sabol, K.E.2    Chou, C.3    Vosmer, G.L.4    Richards, J.5    Seiden, L.S.6
  • 45
    • 0343968021 scopus 로고    scopus 로고
    • 3,4-methylenedioxymethamphetamine (MDMA) 5HT neurotoxicity is a function of ambient temperature and core body temperature in rats
    • Malberg JE, Seiden LS (1996) 3,4-methylenedioxymethamphetamine (MDMA) 5HT neurotoxicity is a function of ambient temperature and core body temperature in rats. Soc Neurosci Abstr 3:1916.
    • (1996) Soc Neurosci Abstr , vol.3 , pp. 1916
    • Malberg, J.E.1    Seiden, L.S.2
  • 46
    • 0030438476 scopus 로고    scopus 로고
    • Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat
    • Malberg JE, Sabol KE, Seiden LS (1996) Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat. J Pharmacol Exp Ther 278:258-267.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 258-267
    • Malberg, J.E.1    Sabol, K.E.2    Seiden, L.S.3
  • 47
    • 0030893740 scopus 로고    scopus 로고
    • Functional subsensitivity to 5HT2A and 5HT2C receptors mediating hyperthermia following acute and chronic treatment with 5HT2A/2C receptor agonists
    • Mazzola-Pomietto P, Aulakh CS, Tolliver T, Murphy DL (1997) Functional subsensitivity to 5HT2A and 5HT2C receptors mediating hyperthermia following acute and chronic treatment with 5HT2A/2C receptor agonists. Psychopharmacology 130:144-151.
    • (1997) Psychopharmacology , vol.130 , pp. 144-151
    • Mazzola-Pomietto, P.1    Aulakh, C.S.2    Tolliver, T.3    Murphy, D.L.4
  • 48
    • 0029846728 scopus 로고    scopus 로고
    • Adverse reactions with 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy")
    • McCann UD, Slate SO, Ricaurte GA (1996) Adverse reactions with 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy"). Drug Saf 15:107-115.
    • (1996) Drug Saf , vol.15 , pp. 107-115
    • McCann, U.D.1    Slate, S.O.2    Ricaurte, G.A.3
  • 49
    • 0027964301 scopus 로고
    • Environment-, drug- And stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse
    • Miller DB, O'Callaghan JP (1994) Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse. J Pharmacol Exp Ther 270:752-760.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 752-760
    • Miller, D.B.1    O'Callaghan, J.P.2
  • 50
    • 0026076203 scopus 로고
    • Temperature dependence of hypoxia-induced calcium accumulation in gerbil hippocampal slices
    • Mitani A, Kadoya F, Kataoka K (1991) Temperature dependence of hypoxia-induced calcium accumulation in gerbil hippocampal slices. Brain Res 562:159-163.
    • (1991) Brain Res , vol.562 , pp. 159-163
    • Mitani, A.1    Kadoya, F.2    Kataoka, K.3
  • 51
    • 0023898060 scopus 로고
    • Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine
    • Nash JF, Meltzer HY, Gudelsky GA (1988) Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine. J Pharmacol Exp Ther 245:873-879.
    • (1988) J Pharmacol Exp Ther , vol.245 , pp. 873-879
    • Nash, J.F.1    Meltzer, H.Y.2    Gudelsky, G.A.3
  • 52
    • 0027967140 scopus 로고
    • Effect of the R(-) and S(+) isomers of MDA and MDMA on phosphotidylinositol turnover in cultured cells expressing 5HT2A and 5HT2C receptors
    • Nash JF, Roth BL, Brodki JD, Nichols DE, Gudelsky GA (1994) Effect of the R(-) and S(+) isomers of MDA and MDMA on phosphotidylinositol turnover in cultured cells expressing 5HT2A and 5HT2C receptors. Neurosci Lett 177:111-115.
    • (1994) Neurosci Lett , vol.177 , pp. 111-115
    • Nash, J.F.1    Roth, B.L.2    Brodki, J.D.3    Nichols, D.E.4    Gudelsky, G.A.5
  • 53
    • 0023735752 scopus 로고
    • Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence for neurotoxicity
    • O'Hearn E, Battaglia G, DeSouza EB, Kuhar MJ, Molliver ME (1988) Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. J Neurosci 8:2788-2803.
    • (1988) J Neurosci , vol.8 , pp. 2788-2803
    • O'Hearn, E.1    Battaglia, G.2    DeSouza, E.B.3    Kuhar, M.J.4    Molliver, M.E.5
  • 54
    • 0026546876 scopus 로고
    • The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: Serotonin transporters are targets for MDMA-induced serotonin release
    • Rudnick G, Wall SC (1992) The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proc Natl Acad Sci USA 89:1817-1821.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1817-1821
    • Rudnick, G.1    Wall, S.C.2
  • 55
    • 0030087890 scopus 로고    scopus 로고
    • Methylenedioxymethamphetamine (MDMA)-induced serotonin deficits are followed by partial recovery over a 52 week period. I. Synaptosomal uptake and tissue concentrations
    • Sabol KE, Lew R, Richards JB, Vosmer GL, Seiden LS (1996) Methylenedioxymethamphetamine (MDMA)-induced serotonin deficits are followed by partial recovery over a 52 week period. I. Synaptosomal uptake and tissue concentrations. J Pharmacol Exp Ther 276:846-854.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 846-854
    • Sabol, K.E.1    Lew, R.2    Richards, J.B.3    Vosmer, G.L.4    Seiden, L.S.5
  • 56
    • 0023163857 scopus 로고
    • Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine
    • Schmidt CJ (1987) Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. J Pharmacol Exp Ther 240:1-7.
    • (1987) J Pharmacol Exp Ther , vol.240 , pp. 1-7
    • Schmidt, C.J.1
  • 57
    • 0022486506 scopus 로고
    • Methylenedioxymethamphetamine: A potentially neurotoxic amphetamine analogue
    • Schmidt CJ, Wu L, Lovenberg W (1986) Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue. Eur J Pharmacol 124:175-178.
    • (1986) Eur J Pharmacol , vol.124 , pp. 175-178
    • Schmidt, C.J.1    Wu, L.2    Lovenberg, W.3
  • 58
    • 0021282148 scopus 로고
    • Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine
    • Seiden LS, Vosmer G (1984) Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine. Pharmacol Biochem Behav 21:29-31.
    • (1984) Pharmacol Biochem Behav , vol.21 , pp. 29-31
    • Seiden, L.S.1    Vosmer, G.2
  • 59
    • 0024495904 scopus 로고
    • Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity
    • Sonsalla PK, Nicklas WJ, Heikkila RE (1989) Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity. Science 243:398-400.
    • (1989) Science , vol.243 , pp. 398-400
    • Sonsalla, P.K.1    Nicklas, W.J.2    Heikkila, R.E.3
  • 60
    • 0024323182 scopus 로고
    • Acute and subchronic effccts of methylenedioxymethamphetamine [(±) MDMA] on locomotion and serotonin syndrome behavior in the rat
    • Spanos LJ, Yamamoto BK (1989) Acute and subchronic effccts of methylenedioxymethamphetamine [(±) MDMA] on locomotion and serotonin syndrome behavior in the rat. Pharmacol Biochem Behav 32:835-840.
    • (1989) Pharmacol Biochem Behav , vol.32 , pp. 835-840
    • Spanos, L.J.1    Yamamoto, B.K.2
  • 61
    • 0029103428 scopus 로고
    • The serotonin syndrome
    • Sporer KA (1995) The serotonin syndrome. Drug Saf 13:94-104.
    • (1995) Drug Saf , vol.13 , pp. 94-104
    • Sporer, K.A.1
  • 62
    • 0028292728 scopus 로고
    • 3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy"): Pharmacology and toxicology in animals and humans
    • Steele TD, McCann UD, Ricaurte GA (1994) 3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy"): pharmacology and toxicology in animals and humans [review]. Addiction 89:539-551.
    • (1994) Addiction , vol.89 , pp. 539-551
    • Steele, T.D.1    McCann, U.D.2    Ricaurte, G.A.3
  • 63
    • 0025869797 scopus 로고
    • The serotonin syndrome
    • Sternbach H (1991) The serotonin syndrome. Am J Psychiatry 148:705-713.
    • (1991) Am J Psychiatry , vol.148 , pp. 705-713
    • Sternbach, H.1
  • 64
    • 0023791701 scopus 로고
    • Role of endogenous dopaminc in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine
    • Stone DM, Johnson M, Hanson GR, Gibb JW (1988) Role of endogenous dopaminc in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine. J Pharmacol Exp Ther 247:79-87.
    • (1988) J Pharmacol Exp Ther , vol.247 , pp. 79-87
    • Stone, D.M.1    Johnson, M.2    Hanson, G.R.3    Gibb, J.W.4
  • 65
    • 0025790173 scopus 로고
    • Extracellular serotonin levels change with behavioral state but not with pyrogen-induced hyperthermia
    • Wilkinson LO, Auerbach SB, Jacobs BL (1991) Extracellular serotonin levels change with behavioral state but not with pyrogen-induced hyperthermia. J Neurosci 11:2732-2741.
    • (1991) J Neurosci , vol.11 , pp. 2732-2741
    • Wilkinson, L.O.1    Auerbach, S.B.2    Jacobs, B.L.3
  • 66
    • 0027359575 scopus 로고
    • Hypothermia, metabolic stress and NMDA-mediated excitotoxicity
    • Zeevalk GD, Nicklas WJ (1993) Hypothermia, metabolic stress and NMDA-mediated excitotoxicity. J Neurochem 61:1445-1453.
    • (1993) J Neurochem , vol.61 , pp. 1445-1453
    • Zeevalk, G.D.1    Nicklas, W.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.