Pharmacological studies of the acute effects of (+)-3,4-methylenedioxymethamphetamine on locomotor activity: Role of 5-HT1B/1D and 5-HT2 receptors

Neuropsychopharmacology

Volumn 26, Issue 1, 2002, Pages 40-52

  Bankson, Michael G ^a   Cunningham, Kathryn A ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

3,4 Methylenedioxymethamphetamine; 5 HT1B receptors; 5 HT2A receptors; 5 HT2C receptors; M100907; MDL 100907; MDMA; SB 206553; Serotonin

Indexed keywords

1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; AMPHETAMINE; FENFLURAMINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SEROTONIN 1B RECEPTOR; SEROTONIN 2 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; HYPERACTIVITY; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLUOROBENZENES; HALLUCINOGENS; INDOLES; MALE; MOTOR ACTIVITY; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; OXADIAZOLES; PIPERAZINES; PIPERIDINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0036147215     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(01)00345-1     Document Type: Article

References (57)

1. Fenfluramine-induced suppression of food intake and locomotor activity is differentially altered by the selective type A monoamine oxidase inhibitor clorgyline
2. 3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions
3. A review of central 5-HT receptors and their function
4. Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites
5. Striatal infusion of serotonin, TFMPP, or m-CPP facilitate dopamine release in vivo
6. 2C receptors
7. Serotonin 5-HT1-like receptors mediate hyperactivity in rats induced by 3,4-methylenedioxymethamphetamine
8. Serotonin release contributes to the locomotor stimulant effects of 3,4-methylenedioxymethamphetamine in rats
9. Suppression of behavioral activity by norfenfluramine and related drugs in rats is not mediated by serotonin release
10. 2C receptor protein in the rat CNS
11. Carrier-dependent and Ca(2+)-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethampheta- mine, p- chloroamphetamine and (+)-fenfluramine
12. GABAergic attenuation of cocaine-induced dopamine release and locomotor activity
13. Selective blockade of serotonin2C/2B receptors enhances dopamine release in the rat nucleus accumbens
14. SB 242084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system
15. Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors
16. Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat
17. Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats
18. Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice
19. 1B receptors with WAY 100,635 and GR 127,935
20. A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA
21. Methysergide potentiates the hyperactivity produced by MDMA in rats
22. MDMA produces stimulant-like conditioned locomotor activity
23. Subjective reports of the effects of MDMA in a clinical setting
24. Studies to investigate the role of 5-HT2C receptors on cocaine- and food-maintained behavior
25. Carrier-mediated release of serotonin by 3,4- methylenedioxymethamphetamine: Implications for serotonin-dopamine interactions
26. A paradoxical locomotor response in serotonin 5-HT(2C) receptor mutant mice
27. Simultaneous microdialysis and amphetamine infusion in the nucleus accumbens and striatum of freely moving rats: Increase in extracellular dopamine and serotonin
28. Effects of the selective 5-HT2A receptor antagonist MDL 100,907 on MDMA-induced locomotor stimulation in rats
29. Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum
30. Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors
31. In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties
32. MDMA induced dopamine release in vivo: Role of endogenous serotonin
33. The effect of serotonergic agents on haloperidol-induced striatal dopamine release in vivo: Opposite role of 5-HT(2A) and 5-HT(2C) receptor subtypes and significance of the haloperidol dose used
34. Role of striatal 5-HT2A and 5-HT2C receptor subtypes in the control of in vivo dopamine outflow in the rat striatum
35. 1B/1D receptors
36. Effects of the 5-HT2C/2B antagonist SB 206553 on hyperactivity induced by cocaine
37. 2B/2C receptors in the potentiative behavioral interactions between serotonin and catecholamine reuptake inhibitors
38. 2A receptors attenuates the behavioral effects of cocaine in rats
39. Ketanserin pretreatment attenuates MDMA-induced dopamine release in the striatum as measured by in vivo microdialysis
40. Regulation of striatal dopamine release through 5-HT1 and 5-HT2 receptors
41. GR 127935 blocks the locomotor and antidepressant-like effects of RU 24969 and the action of antidepressants in the mouse tail suspension test
42. 1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine
43. The effects of MDMA and other methylenedioxy-substituted phenylalkylamines on the structure of rat locomotor activity
44. 2C receptors
45. Serotonin1B receptor activation mimics behavioral effects of presynaptic serotonin release
46. Role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine
47. The molecular mechanism of "ecstasy" (3,4-methylenedioxy- methamphetamine (MDMA)): Serotonin transporters are targets for MDMA- induced serotonin release
48. 2 receptors reduces the increase in extracellular concentrations of dopamine produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine
49. 2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: Behavioral, electrophysiological and neurochemical studies
50. Acute and subchronic effects of methylenedioxymethamphetamine ((+/-)-MDMA) on locomotion and serotonin syndrome behavior in the rat
51. Behavioral evidence for the rapid release of CNS serotonin by PCA and fenfluramine
52. D-fenfluramine selectively releases 5-HT from dorsal raphe terminals
53. Methylenedioxymethamphetamine depresses glutamate-evoked neuronal firing and increases extracellular levels of dopamine and serotonin in the nucleus accumbens in vivo
54. Brain mechanisms of drug reward and euphoria
55. Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra
56. The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat