Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 30, Issue 3, 2015, Pages 389-395

  Shafii, Negah ^a   Khoobi, Mehdi ^b   Amini, Mohsen ^b   Sakhteman, Amirhossein ^c   Nadri, Hamid ^c   Moradi, Alireza ^c   Emami, Saeed ^d   Saeedian Moghadam, Ebrahim ^b   Foroumadi, Alireza ^b   Shafiee, Abbas ^a,b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

15 lipoxygenase; 2 Thioxothiazolidin 4 one; Acetylcholinesterase; Docking study; Inhibitors; Rhodanines

Indexed keywords

2 [5 (4 CHLOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] N (1 BENZYLPIPERIDIN 4 YL)ACETAMIDE; 2 [5 (4 METHYLBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] N (1 BENZYLPIPERIDIN 4 YL)ACETAMIDE; 2 [5 [4 (DIMETHYLAMINO)BENZYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] N (1 BENZYLPIPERIDIN 4 YL)ACETAMIDE; 3 (2 MORPHOLINO 2 OXOETHYL) 2 THIOXO 5 (3,4,5 TRIMETHOXYBENZYLIDENE)THIAZOLIDIN 4 ONE; 3 [2 (4 BENZYLPIPERIDIN 1 YL) 2 OXOETHYL] 5 (3 HYDROXY 4 METHOXYBENZYLIDENE) 2 THIOXOTHIAZOLIDIN 4 ONE; 3 [2 (4 BENZYLPIPERIDIN 1 YL) 2 OXOETHYL] 5 [4 (DIMETHYLAMINO)BENZYLIDENE] 2 THIOXOTHIAZOLIDIN 4 ONE; 3 [2 OXO 2 (4 PHENYLPIPERAZINE 1 YL)ETHYL] 2 THIOXO 5 (3,4,5 TRIMETHOXYBENZYLIDENE)THIAZOLIDIN 4 ONE; 3 [2 [4 (3 FLUOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL] 2 THIOXO 5 (3,4,5 TRIMETHOXYBENZYLIDENE)THIAZOLIDIN 4 ONE; 3 [2 [4 (3,4 DICHLOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL] 5 (2,3 DIMETHOXYBENZYLIDENE) 2 THIOXOTHIAZOLIDIN 4 ONE; 3 [2 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHYL] 2 THIOXO 5 (3,4,5 TRIMETHOXYBENZYLIDENE)THIAZOLIDIN 4 ONE; 5 (4 CHOLOROBENZYLIDENE) 3 (2 MORPHOLINO 2OXOETHYL) 2 THIOXOTHIAZOLIDIN 4 ONE; 5 (4 METHOXYBENZYLIDENE) 3 (2 MORPHOLINO 2 OXOETHYL) 2 THIOXOTHIAZOLIDIN 4 ONE; 5 BENZYLIDENERHODANINE 3 ACETAMIDE DERIVATIVE; 5 BENZYLIDENERHODANINE 3 ACETIC ACID DERIVATIVE; 5 [4 (DIMETHYLAMINO)BENZYLIDENE] 3 (2 MORPHOLINO 2 OXOETHYL) 2 THIOXOTHIAZOLIDIN 4 ONE; ACETYLCHOLINESTERASE; ARACHIDONATE 15 LIPOXYGENASE; CHOLINESTERASE INHIBITOR; LIPOXYGENASE INHIBITOR; RHODANINE; TACRINE; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE;

ALDOL REACTION; ANALYTIC METHOD; ARTICLE; BIOLOGICAL ACTIVITY; CLINICAL EVALUATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR DOCKING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; SYNTHESIS;

ACETATES; ACETYLCHOLINESTERASE; ARACHIDONATE 15-LIPOXYGENASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPOXYGENASE INHIBITORS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; RHODANINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937030119     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2014.940935     Document Type: Article

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