Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors

European Journal of Medicinal Chemistry

Volumn 68, Issue , 2013, Pages 260-269

  Khoobi, Mehdi ^a   Alipour, Masoumeh ^b   Sakhteman, Amirhossein ^c   Nadri, Hamid ^c   Moradi, Alireza ^c   Ghandi, Mehdi ^b   Emami, Saeed ^d   Foroumadi, Alireza ^a,e   Shafiee, Abbas ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TEHRAN   (Iran)

^c SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Chromenes; Coumarins; Docking study

Indexed keywords

3 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (2 CHLOROBENZYL)PYRIDINIUM CHLORIDE; 3 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (2 FLUOROBENZYL)PYRIDINIUM CHLORIDE; 3 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (3 CHLOROBENZYL)PYRIDINIUM CHLORIDE; 3 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (3 FLUOROBENZYL)PYRIDINIUM CHLORIDE; 3 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (3 METHYLBENZYL)PYRIDINIUM CHLORIDE; 3 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (4 FLUOROBENZYL)PYRIDINIUM CHLORIDE; 4 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (2 CHLOROBENZYL)PYRIDINIUM CHLORIDE; 4 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (2 FLUOROBENZYL)PYRIDINIUM CHLORIDE; 4 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (2 METHYLBENZYL)PYRIDINIUM CHLORIDE; 4 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (2,4 FLUOROBENZYL)PYRIDINIUM CHLORIDE; 4 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (3 CHLOROBENZYL)PYRIDINIUM CHLORIDE; 4 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (3 FLUOROBENZYL)PYRIDINIUM CHLORIDE; 4 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (3 METHYLBENZYL)PYRIDINIUM CHLORIDE; 4 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (3,4 DICHLOROBENZYL)PYRIDINIUM CHLORIDE; 4 (2 AMINO 3 CYANO 5 OXO 4,5 DIHYDROPYRANO[3,2 C] CHROMEN 4 YL) 1 (4 FLUOROBENZYL)PYRIDINIUM CHLORIDE; 5 OXO 4,5 DIHYDROPYRANOL[3,2 C]CHROMENE; CHOLINESTERASE INHIBITOR; CHROMENE DERIVATIVE; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHOLINESTERASE INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ALZHEIMER'S DISEASE; CHROMENES; COUMARINS; DOCKING STUDY;

ACETYLCHOLINESTERASE; BENZOPYRANS; BINDING SITES; BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; DRUG DESIGN; ENZYME ACTIVATION; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84883118710     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.038     Document Type: Article

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