Synthesis and aldose reductase inhibitory activity of a new series of 5- [[2-(ω-carboxyalkoxy)aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives

European Journal of Medicinal Chemistry

Volumn 34, Issue 12, 1999, Pages 1061-1070

  Murata, Makoto ^a   Fujitani, Buichi ^a   Mizuta, Hiroyuki ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

5 2 ( carboxyalkoxy)aryl methylene 4 oxo 2 thioxothiazolidine derivatives; Aldose reductase inhibitory activity; Sorbitol accumulation inhibition

Indexed keywords

5 [2 (3 CARBOXYPROPOXY) 1 NAPHTHYLMETHYLENE] 3 METHYL 4 OXO 2 THIOXOTHIAZOLIDINE; ALDOSE REDUCTASE INHIBITOR; SORBITOL; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZENARESTAT;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STREPTOZOCIN DIABETES;

EID: 0033398826     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)00128-2     Document Type: Article

References (20)

1. Hayman S., Kinoshita J.H. J. Biol. Chem. 240:1965;877-882.
2. Kador P.F., Akagi Y., Kinoshita J.H. Metabolism. 35:1986 suppl. 1;15-19.
3. Gabbay K.H. New Engl. J. M. 288:1973;831-836.
4. Akagi Y., Kador P.F., Kuwabara T., Kinoshita J.H. Invest. Ophthalmol. Vis. Sci. 24:1983;1516-1519.
5. Cohen M.P. Metabolism. 35:1986 suppl. 1;55-59.
6. Varma S.D., Schocket S.S., Richards R.D. Invest. Ophthalmol. Vis. Sci. 18:1979;237-241.
7. Canal N., Comi G. Trends Pharmacol. Sci. 6:1985;328-330.
8. Sestanj K., Bellini F., Fung S., Abraham N., Treasurywala A., Humber L., Simard-Duquesne N., Dvornik D. J. Med. Chem. 27:1984;255-256.
9. Kikkawa R., Hatanaka I., Yasuda H., Kobayashi N., Shigeta Y., Terashima H., Morimura T., Tsuboshima M. Diabetlogia. 24:1983;290-292.
10. Mizuno K., Kato N., Matsubara A., Nakano K., Kurono M. Metabolism. 41:1992;1081-1086.
11. Ao S., Shingu Y., Kikuchi C., Takano Y., Nomura K., Fujiwara T. Metabolism. 40:1991;77-87.
12. Kador P.F., Kinoshita J.H., Sharpless N.E. J. Med. Chem. 28:1985;841-849.
13. Lee Y.S., Pearlstein R., Kador P.F. J. Med. Chem. 37:1994;787-792.
14. Emmott P., Livingstone R. J. Chem. Soc. 1957;3144-3148.
15. Gresham T.L., Jansen J.E., Shaver F.W., Bankert R.A., Beears W.L., Prendergast M.G. J. Am. Chem. Soc. 71:1949;661-663.
16. Baranov S.N., Komaritsa I.D. Khim. Geterotsikl. Soedin. Akad. Nauk Latv. SSR. 1:1965;69-73.
17. Fresneau P., Cussac M., Morand J.M., Szymonski B., Tranqui D., Leclerc G. J. Med. Chem. 41:1998;4706-4715.
18. Ishida T., In Y., Inoue M., Ueno Y., Tanaka C. Tetrahedron Lett. 30:1989;959-962.
19. Clements R.S., Morisson A.D. Jr, Winegrad A.I. Science. 166:1969;1007-1008.
20. Hullar T.L., Failla D.L. J. Med. Chem. 12:1969;420-424.