Reduction of mitochondrial function by FCCP during mouse cleavage stage embryo culture reduces birth weight and impairs the metabolic health of offspring

Biology of Reproduction

Volumn 92, Issue 5, 2015, Pages

  Zander Fox, Deirdre L ^a,b   Fullston, Tod ^a   McPherson, Nicole O ^a   Sandeman, Lauren ^a   Kang, Wan Xian ^a   Good, Suzanne B ^a   Spillane, Marni ^a   Lane, Michelle ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b Repromed   (Australia)

Author keywords

Blastocyst; Developmental origins of health and disease; Embryo; Embryo culture; Fetal development; Mitochondria; Pregnancy; Preimplantation embryo

Indexed keywords

CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; ADENOSINE TRIPHOSPHATE; METALLOPROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIRTH WEIGHT; BLASTOCYST; BODY MASS; CALCIUM CELL LEVEL; CELL PH; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO CULTURE; EMBRYO TRANSFER; FEMALE; FETUS DEVELOPMENT; FETUS GROWTH; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; HUMAN; INNER CELL MASS; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; ANIMAL; DRUG EFFECTS; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENETICS; LITTER SIZE; METABOLISM; MITOCHONDRION; OOCYTE CLEAVAGE; PREGNANCY; PRENATAL EXPOSURE;

ADENOSINE TRIPHOSPHATE; ADIPOSITY; ANIMALS; BIRTH WEIGHT; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CLEAVAGE STAGE, OVUM; EMBRYO CULTURE TECHNIQUES; EMBRYO TRANSFER; EMBRYONIC DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LITTER SIZE; MALE; METALLOPROTEASES; MICE; MITOCHONDRIA; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 84937029780     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.114.123489     Document Type: Article

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