Fatty acid composition of the follicular fluid of normal weight, overweight and obese women undergoing assisted reproductive treatment: A descriptive cross-sectional study

Reproductive Biology and Endocrinology

Volumn 12, Issue 1, 2014, Pages

  Valckx, Sara D M ^a   Arias Alvarez, Maria ^b   De Pauw, Ingrid ^c   Fievez, Veerle ^d   Vlaeminck, Bruno ^d   Fransen, Erik ^a   Bols, Peter E J ^a   Leroy, Jo L M R ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c ZNA Middelheim   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

Author keywords

ART; BMI; Fatty acid; Follicular fluid; NEFA; Obesity

Indexed keywords

CHOLESTEROL ESTER; FATTY ACID; PHOSPHOLIPID; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; INFERTILITY THERAPY; LIPID COMPOSITION; OBESITY; OVARY FOLLICLE FLUID;

ADULT; BODY WEIGHT; CROSS-SECTIONAL STUDIES; FATTY ACIDS; FEMALE; FOLLICULAR FLUID; HUMANS; OBESITY; OVERWEIGHT; REPRODUCTIVE TECHNIQUES, ASSISTED;

EID: 84893171175     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-12-13     Document Type: Article

References (49)

1. Renaville B, Bacciu N, Comin A, Motta M, Poli I, Vanini G, Prandi A. Plasma and follicular fluid fatty acid profiles in dairy cows. Reprod Domest Anim 2010, 45:118-121. 10.1111/j.1439-0531.2008.01264.x, 19055554.
2. Sturmey RG, Reis A, Leese HJ, McEvoy TG. Role of fatty acids in energy provision during oocyte maturation and early embryo development. Reprod Domest Anim 2009, 44(Suppl 3):50-58.
3. McKeegan PJ, Sturmey RG. The role of fatty acids in oocyte and early embryo development. Reprod Fert Develop 2012, 24:59-67.
4. Mattos R, Staples CR, Thatcher WW. Effects of dietary fatty acids on reproduction in ruminants. Rev Reprod 2000, 5:38-45. 10.1530/ror.0.0050038, 10711734.
5. Hughes J, Kwong WY, Li DF, Salter AM, Lea RG, Sinclair KD. Effects of omega-3 and-6 polyunsaturated fatty acids on ovine follicular cell steroidogenesis, embryo development and molecular markers of fatty acid metabolism. Reproduction 2011, 141:105-118. 10.1530/REP-10-0337, 21045166.
6. Zachut M, Dekel I, Lehrer H, Arieli A, Arav A, Livshitz L, Yakoby S, Moallem U. Effects of dietary fats differing in n-6:n-3 ratio fed to high-yielding dairy cows on fatty acid composition of ovarian compartments, follicular status, and oocyte quality. J Dairy Sci 2010, 93:529-545. 10.3168/jds.2009-2167, 20105525.
7. Adamiak SJ, Powell K, Rooke JA, Webb R, Sinclair KD. Body composition, dietary carbohydrates and fatty acids determine post-fertilisation development of bovine oocytes in vitro. Reproduction 2006, 131:247-258. 10.1530/rep.1.00871, 16452718.
8. Wonnacott KE, Kwong WY, Hughes J, Salter AM, Lea RG, Garnsworthy PC, Sinclair KD. Dietary omega-3 and-6 polyunsaturated fatty acids affect the composition and development of sheep granulosa cells, oocytes and embryos. Reproduction 2010, 139:57-69. 10.1530/REP-09-0219, 19789173.
9. Petit HV, Dewhurst RJ, Scollan ND, Proulx JG, Khalid M, Haresign W, Twagiramungu H, Mann GE. Milk production and composition, ovarian function, and prostaglandin secretion of dairy cows fed omega-3 fats. J Dairy Sci 2002, 85:889-899. 10.3168/jds.S0022-0302(02)74147-7, 12018434.
10. Zeron Y, Sklan D, Arav A. Effect of polyunsaturated fatty acid supplementation on biophysical parameters and chilling sensitivity of ewe oocytes. Mol Reprod Dev 2002, 61:271-278. 10.1002/mrd.1156, 11803563.
11. Igosheva N, Abramov AY, Poston L, Eckert JJ, Fleming TP, Duchen MR, McConnell J. Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS One 2010, 5:e10074. 10.1371/journal.pone.0010074, 2852405, 20404917.
12. Wu LLY, Dunning KR, Yang X, Russell DL, Lane M, Norman RJ, Robker RL. High-Fat diet causes lipotoxicity responses in cumulus-oocyte complexes and decreased fertilization rates. Endocrinology 2010, 151:5438-5445. 10.1210/en.2010-0551, 20861227.
13. Yi D, Zeng S, Guo Y. A diet rich in n-3 polyunsaturated fatty acids reduced prostaglandin biosynthesis, ovulation rate, and litter size in mice. Theriogenology 2012, 78:28-38. 10.1016/j.theriogenology.2012.01.013, 22460154.
14. Jungheim ES, Schoeller EL, Marquard KL, Louden ED, Schaffer JE, Moley KH. Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring. Endocrinology 2010, 151:4039-4046. 10.1210/en.2010-0098, 2940512, 20573727.
15. Leroy JL, Vanholder T, Mateusen B, Christophe A, Opsomer G, de Kruif A, Genicot G, Van Soom A. Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro. Reproduction 2005, 130:485-495. 10.1530/rep.1.00735, 16183866.
16. Karpe F, Dickmann JR, Frayn KN. Fatty acids, obesity, and insulin resistance: time for a reevaluation. Diabetes 2011, 60:2441-2449. 10.2337/db11-0425, 3178283, 21948998.
17. Valckx SD, De Pauw I, De Neubourg D, Inion I, Berth M, Fransen E, Bols PE, Leroy JL. BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality. Hum Reprod 2012, 27:3531-3539. 10.1093/humrep/des350, 23019302.
18. Yang X, Wu LL, Chura LR, Liang X, Lane M, Norman RJ, Robker RL. Exposure to lipid-rich follicular fluid is associated with endoplasmic reticulum stress and impaired oocyte maturation in cumulus-oocyte complexes. Fertil Steril 2012, 97:1438-1443. 10.1016/j.fertnstert.2012.02.034, 22440252.
19. Jungheim ES, Macones GA, Odem RR, Patterson BW, Lanzendorf SE, Ratts VS, Moley KH. Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization. Fertil Steril 2011, 95:1970-1974. 10.1016/j.fertnstert.2011.01.154, 3080431, 21353671.
20. Van Hoeck V, Sturmey RG, Bermejo-Alvarez P, Rizos D, Gutierrez-Adan A, Leese HJ, Bols PE, Leroy JL. Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. PLoS One 2011, 6:e23183. 10.1371/journal.pone.0023183, 3157355, 21858021.
21. Van Hoeck V, Leroy JLMR, Arias-Alvarez M, Rizos D, Gutierrez-Adan A, Schnorbusch K, Bols PEJ, Leese HJ, Sturmey RG. Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights. Reproduction 2013, 145:33-44. 10.1530/REP-12-0174, 23108110.
22. Jungheim ES, Frolova AI, Jiang H, Riley JK. Relationship between serum polyunsaturated fatty acids and pregnancy in women undergoing in vitro fertilization. J Clin Endocr Metab 2013, 98:E1364-E1368. 10.1210/jc.2012-4115, 23780371.
23. Shaaker M, Rahimipour A, Nouri M, Khanaki K, Darabi M, Farzadi L, Shahnazi V, Mehdizadeh A. Fatty acid composition of human follicular fluid phospholipids and fertilization rate in assisted reproductive techniques. Iran Biomed J 2012, 16:162-168. 3629932, 23023218.
24. Koning AMH, Kuchenbecker WKH, Groen H, Hoek A, Land JA, Khan KS, Mol BWJ. Economic consequences of overweight and obesity in infertility: a framework for evaluating the costs and outcomes of fertility care. Hum Reprod Update 2010, 16:246-254. 10.1093/humupd/dmp053, 20056674.
25. Obesity and overweight. Fact sheet N° 311. http://www.who.int/mediacentre/factsheets/fs311/en/index.html.
26. Van Royen E, Mangelschots K, De Neubourg D, Valkenburg M, Van de Meerssche M, Ryckaert G, Eestermans W, Gerris J. Characterization of a top quality embryo, a step towards single-embryo transfer. Hum Reprod 1999, 14:2345-2349. 10.1093/humrep/14.9.2345, 10469708.
27. Matyash V, Liebisch G, Kurzchalia TV, Shevchenko A, Schwudke D. Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. J Lipid Res 2008, 49:1137-1146. 10.1194/jlr.D700041-JLR200, 2311442, 18281723.
28. Burdge GC, Wright P, Jones AE, Wootton SA. A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid-phase extraction. Brit J Nutr 2000, 84:781-787.
29. Pinkart HC, Devereux R, Chapman PJ. Rapid separation of microbial lipids using solid phase extraction columns. J Microbiol Meth 1998, 34:9-15.
30. Chouinard PY, Levesque J, Girard V, Brisson GJ. Dietary soybeans extruded at different temperatures: milk composition and in situ fatty acid reactions. J Dairy Sci 1997, 80:2913-2924. 10.3168/jds.S0022-0302(97)76257-X, 9406085.
31. Precht D, Molkentin J, Destaillats F, Wolff RL. Comparative studies on individual isomeric 18: 1 acids in cow, goat, and ewe milk fats by low-temperature high-resolution capillary gas-liquid chromatography. Lipids 2001, 36:827-832. 10.1007/s11745-001-0791-8, 11592734.
32. Kramer JKG, Hernandez M, Cruz-Hernandez C, Kraft J, Dugan MER. Combining results of two GC separations partly achieves determination of all cis and trans 16: 1, 18: 1, 18: 2 and 18: 3 except CLA isomers of milk fat as demonstrated using ag-ion SPE fractionation. Lipids 2008, 43:259-273. 10.1007/s11745-007-3143-4, 18214567.
33. The R project for statistical computing. [http://www.r-project.org/].
34. Agresti A. Categorical Data Analysis 2002, New York, USA: Wiley-Interscience, 2.
35. Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, Lane M, Norman RJ. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocr Metab 2009, 94:1533-1540. 10.1210/jc.2008-2648, 19223519.
36. Aardema H, Vos PL, Lolicato F, Roelen BA, Knijn HM, Vaandrager AB, Helms JB, Gadella BM. Oleic acid prevents detrimental effects of saturated fatty acids on bovine oocyte developmental competence. Biol Reprod 2011, 85:62-69. 10.1095/biolreprod.110.088815, 21311036.
37. Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 2001, 50:1771-1777. 10.2337/diabetes.50.8.1771, 11473037.
38. Vanholder T, Leroy JL, Soom AV, Opsomer G, Maes D, Coryn M, de Kruif A. Effect of non-esterified fatty acids on bovine granulosa cell steroidogenesis and proliferation in vitro. Anim Reprod Sci 2005, 87:33-44. 10.1016/j.anireprosci.2004.09.006, 15885439.
39. Vanholder T, Leroy JL, Van Soom A, Maes D, Coryn A, Fiers T, de Kruif A, Opsomer G. Effect of non-esterified fatty acids on bovine theca cell steroidogenesis and proliferation in vitro. Anim Reprod Sci 2006, 92:51-63. 10.1016/j.anireprosci.2005.05.014, 15978752.
40. Mu YM, Yanase T, Nishi Y, Tanaka A, Saito M, Jin CH, Mukasa C, Okabe T, Nomura M, Goto K, Nawata H. Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells. Endocrinology 2001, 142:3590-3597. 10.1210/endo.142.8.8293, 11459807.
41. Marei WF, Wathes DC, Fouladi-Nashta AA. Impact of linoleic acid on bovine oocyte maturation and embryo development. Reproduction 2010, 139:979-988. 10.1530/REP-09-0503, 20215338.
42. Marei WF, Wathes DC, Fouladi-Nashta AA. The effect of linolenic acid on bovine oocyte maturation and development. Biol Reprod 2009, 81:1064-1072. 10.1095/biolreprod.109.076851, 19587335.
43. Homa ST, Brown CA. Changes in linoleic-acid during follicular development and inhibition of spontaneous breakdown of germinal vesicles in cumulus-free bovine oocytes. J Reprod Fertil 1992, 94:153-160. 10.1530/jrf.0.0940153, 1552477.
44. Zhang LY, Keung W, Samokhvalov V, Wang W, Lopaschuk GD. Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle. Bba-Mol Cell Biol L 1801, 2010:1-22.
45. Klop B, Elte JWF, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients 2013, 5:1218-1240. 10.3390/nu5041218, 3705344, 23584084.
46. Hostens M, Fievez V, Leroy JLMR, Van Ranst J, Vlaeminck B, Opsomer G. The fatty acid profile of subcutaneous and abdominal fat in dairy cows with left displacement of the abomasum. J Dairy Sci 2012, 95:3756-3765. 10.3168/jds.2011-5092, 22720932.
47. Garaulet M, Hernandez-Morante JJ, Lujan J, Tebar FJ, Zamora S. Relationship between fat cell size and number and fatty acid composition in adipose tissue from different fat depots in overweight/obese humans. Int J Obes (Lond) 2006, 30:899-905. 10.1038/sj.ijo.0803219, 16446749.
48. Zachut M, Arieli A, Moallem U. Incorporation of dietary n-3 fatty acids into ovarian compartments in dairy cows and the effects on hormonal and behavioral patterns around estrus. Reproduction 2011, 141:833-840. 10.1530/REP-10-0518, 21389076.
49. Palomba S, Russo T, Orio F, Sammartino A, Sbano FM, Nappi C, Colao A, Mastrantonio P, Lombardi G, Zullo F. Lipid, glucose and homocysteine metabolism in women treated with a GnRH agonist with or without raloxifene. Hum Reprod 2004, 19:415-421. 10.1093/humrep/deh053, 14747190.