메뉴 건너뛰기




Volumn 30, Issue 1, 2015, Pages 122-132

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities

Author keywords

endogenous triglyceride; human embryo metabolism; obesity; precocious development

Indexed keywords

ASPARAGINE; ASPARTIC ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; ISOLEUCINE; LACTIC ACID; PYRUVIC ACID; TRIACYLGLYCEROL; TRYPTOPHAN;

EID: 84922452904     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/deu276     Document Type: Article
Times cited : (153)

References (53)
  • 2
    • 79952987886 scopus 로고    scopus 로고
    • Paternal body mass inDex is associated with Decreased blastocyst Development and reduced live birth rates following assisted reproductive technology
    • Bakos HW, Henshaw RC, Mitchell M, Lane M. Paternal body mass inDex is associated with Decreased blastocyst Development and reduced live birth rates following assisted reproductive technology. Fertil Steril 2011; 95:1700-1704
    • (2011) Fertil Steril , vol.95 , pp. 1700-1704
    • Bakos, H.W.1    Henshaw, R.C.2    Mitchell, M.3    Lane, M.4
  • 3
    • 36749056858 scopus 로고    scopus 로고
    • Policy, practice committee of the bfs impact of obesity on female reproductive health: British Fertility Society, Policy and Practice GuiDelines
    • Balen AH, AnDerson RA, Policy, Practice Committee of the BFS. Impact of obesity on female reproductive health: British Fertility Society, Policy and Practice GuiDelines. Hum Fertil 2007;10:195-206
    • (2007) Hum Fertil , vol.10 , pp. 195-206
    • Balen, A.H.1    Anderson, R.A.2
  • 4
    • 0025297450 scopus 로고
    • Fetal and placental size and risk of hypertension in adult life
    • Barker DJ, Bull AR, Osmond C, Simmonds SJ. Fetal and placental size and risk of hypertension in adult life. Br Med J 1990;301:259-262
    • (1990) Br Med J , vol.301 , pp. 259-262
    • Barker, D.J.1    Bull, A.R.2    Osmond, C.3    Simmonds, S.J.4
  • 6
    • 84874314336 scopus 로고    scopus 로고
    • Similar morphokinetic patterns in embryos Derived from obese and normoweight infertile women: A time-lapse study
    • Bellver J, Mifsud A, Grau N, Privitera L, Meseguer M. Similar morphokinetic patterns in embryos Derived from obese and normoweight infertile women: a time-lapse study. Hum Reprod 2013;28:794-800
    • (2013) Hum Reprod , vol.28 , pp. 794-800
    • Bellver, J.1    Mifsud, A.2    Grau, N.3    Privitera, L.4    Meseguer, M.5
  • 7
    • 0028595559 scopus 로고
    • Internal pilot studies for estimating sample size
    • Birkett MA, Day SJ. Internal pilot studies for estimating sample size. Stat Med 1994;13:2455-2463
    • (1994) Stat Med , vol.13 , pp. 2455-2463
    • Birkett, M.A.1    Day, S.J.2
  • 8
    • 83455231302 scopus 로고    scopus 로고
    • Does obesity increase the risk of miscarriage in spontaneous conception: A systematic review
    • Boots C, Stephenson MD. Does obesity increase the risk of miscarriage in spontaneous conception: a systematic review. Semin Reprod Med 2011; 29:507-513
    • (2011) Semin Reprod Med , vol.29 , pp. 507-513
    • Boots, C.1    Stephenson, M.D.2
  • 11
    • 84862998024 scopus 로고    scopus 로고
    • Body mass inDex and short-term weight change in relation to treatment outcomes in women unDergoing assisted reproduction
    • Chavarro JE, Ehrlich S, Colaci DS, Wright DL, Toth TL, Petrozza JC, Hauser R. Body mass inDex and short-term weight change in relation to treatment outcomes in women unDergoing assisted reproduction. Fertil Steril 2012; 98:109-116
    • (2012) Fertil Steril , vol.98 , pp. 109-116
    • Chavarro, J.E.1    Ehrlich, S.2    Colaci, D.S.3    Wright, D.L.4    Toth, T.L.5    Petrozza, J.C.6    Hauser, R.7
  • 12
    • 84860330718 scopus 로고    scopus 로고
    • Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring Development and reproductive function
    • Connor KL, Vickers MH, Beltrand J, Meaney MJ, Sloboda DM. Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring Development and reproductive function. J Physiol 2012; 590:2167-2180
    • (2012) J Physiol , vol.590 , pp. 2167-2180
    • Connor, K.L.1    Vickers, M.H.2    Beltrand, J.3    Meaney, M.J.4    Sloboda, D.M.5
  • 13
    • 74549151054 scopus 로고    scopus 로고
    • Insulin resistance and free androgen inDex correlate with the outcome of controlled ovarian hyperstimulation in non-PCOS women unDergoing IVF
    • Dickerson EH, ChoLW, Maguiness SD, Killick SL, Robinson J, Atkin SL. Insulin resistance and free androgen inDex correlate with the outcome of controlled ovarian hyperstimulation in non-PCOS women unDergoing IVF. Hum Reprod 2010;25:504-509
    • (2010) Hum Reprod , vol.25 , pp. 504-509
    • Dickerson, E.H.1    Cholw Maguiness, S.D.2    Killick, S.L.3    Robinson, J.4    Atkin, S.L.5
  • 14
    • 77957729516 scopus 로고    scopus 로고
    • Beta-oxidation is essential for mouse oocyte Developmental competence and early embryo Development
    • Dunning KR, Cashman K, Russell DL, Thompson JG, Norman RJ, Robker RL. Beta-oxidation is essential for mouse oocyte Developmental competence and early embryo Development. Biol Reprod 2010;83:909-918
    • (2010) Biol Reprod , vol.83 , pp. 909-918
    • Dunning, K.R.1    Cashman, K.2    Russell, D.L.3    Thompson, J.G.4    Norman, R.J.5    Robker, R.L.6
  • 16
    • 78049414227 scopus 로고    scopus 로고
    • Epigenetic reprogramming in plant and animal Development
    • Feng S, Jacobsen SE, ReikW. Epigenetic reprogramming in plant and animal Development. Science 2010;330:622-627
    • (2010) Science , vol.330 , pp. 622-627
    • Feng, S.1    Jacobsen, S.E.2    Reik, W.3
  • 17
    • 0032783096 scopus 로고    scopus 로고
    • TriglyceriDe content of bovine oocytes and early embryos
    • Ferguson EM, Leese HJ. TriglyceriDe content of bovine oocytes and early embryos. J Reprod Fertil 1999;116:373-378
    • (1999) J Reprod Fertil , vol.116 , pp. 373-378
    • Ferguson, E.M.1    Leese, H.J.2
  • 18
    • 33746619170 scopus 로고    scopus 로고
    • A potential role for triglyceriDe as an energy source during bovine oocyte maturation and early embryo Development
    • Ferguson EM, Leese HJ. A potential role for triglyceriDe as an energy source during bovine oocyte maturation and early embryo Development. Mol Reprod Dev 2006;73:1195-1201
    • (2006) Mol Reprod Dev , vol.73 , pp. 1195-1201
    • Ferguson, E.M.1    Leese, H.J.2
  • 19
    • 79960512930 scopus 로고    scopus 로고
    • Glucose consumption of single post-compaction human embryos is predictive of embryo sex and live birth outcome
    • Gardner DK, Wale PL, Collins R, Lane M. Glucose consumption of single post-compaction human embryos is predictive of embryo sex and live birth outcome. Hum Reprod 2011;26:1981-1986
    • (2011) Hum Reprod , vol.26 , pp. 1981-1986
    • Gardner, D.K.1    Wale, P.L.2    Collins, R.3    Lane, M.4
  • 20
    • 4544366928 scopus 로고    scopus 로고
    • Living with the past: Evolution, Development, and patterns of disease
    • Gluckman PD, HansonMA.Living with the past: evolution, Development, and patterns of disease. Science 2004;305:1733-1736
    • (2004) Science , vol.305 , pp. 1733-1736
    • Gluckman, P.D.1    Hanson, M.A.2
  • 21
    • 0025346983 scopus 로고
    • Non-invasive measurement of pyruvate and glucose uptake and lactate production by single human preimplantation embryos
    • Gott AL, Hardy K, Winston RM, Leese HJ. Non-invasive measurement of pyruvate and glucose uptake and lactate production by single human preimplantation embryos. Hum Reprod 1990;5:104-108
    • (1990) Hum Reprod , vol.5 , pp. 104-108
    • Gott, A.L.1    Hardy, K.2    Winston, R.M.3    Leese, H.J.4
  • 22
    • 39049152367 scopus 로고    scopus 로고
    • S-ADenosylmethionine and its products
    • Grillo MA, Colombatto S. S-ADenosylmethionine and its products. Amino Acids 2008;34:187-193
    • (2008) Amino Acids , vol.34 , pp. 187-193
    • Grillo, M.A.1    Colombatto, S.2
  • 23
    • 84881574750 scopus 로고    scopus 로고
    • A Simple Approach for COnsumption and RElease (CORE) analysis of metabolic activity in single mammalian embryos
    • Guerif F, McKeegan P, Leese HJ, Sturmey RG. A Simple Approach for COnsumption and RElease (CORE) analysis of metabolic activity in single mammalian embryos. PloS One 2013;8:e67834
    • (2013) PloS One , vol.8 , pp. e67834
    • Guerif, F.1    McKeegan, P.2    Leese, H.J.3    Sturmey, R.G.4
  • 24
    • 81755188367 scopus 로고    scopus 로고
    • Developmental origins of noncommunicable disease: Population and public health implications
    • Hanson M, Gluckman P. Developmental origins of noncommunicable disease: population and public health implications. Am J Clin Nutr 2011; 94:1754S-1758S
    • (2011) Am J Clin Nutr , vol.94 , pp. 1754S-1758S
    • Hanson, M.1    Gluckman, P.2
  • 25
    • 0024512816 scopus 로고
    • Non-invasive measurement of glucose and pyruvate uptake by individual human oocytes and preimplantation embryos
    • Hardy K, HooperMA, HandysiDeAH, Rutherford AJ, WinstonRM, Leese HJ. Non-invasive measurement of glucose and pyruvate uptake by individual human oocytes and preimplantation embryos. Hum Reprod 1989; 4:188-191
    • (1989) Hum Reprod , vol.4 , pp. 188-191
    • Hardy, K.1    Hooper, M.A.2    Handyside, A.H.3    Rutherford, A.J.4    Winston, R.M.5    Leese, H.J.6
  • 27
    • 69049098306 scopus 로고    scopus 로고
    • The Randle cycle revisited: A new head for an old hat
    • Hue L, Taegtmeyer H. The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab 2009;297:E578-E591
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. E578-E591
    • Hue, L.1    Taegtmeyer, H.2
  • 28
    • 84860209467 scopus 로고    scopus 로고
    • Time-lapse monitoring as a tool for clinical embryo assessment
    • Kirkegaard K, Agerholm IE, Ingerslev HJ. Time-lapse monitoring as a tool for clinical embryo assessment. Hum Reprod 2012;27:1277-1285
    • (2012) Hum Reprod , vol.27 , pp. 1277-1285
    • Kirkegaard, K.1    Agerholm, I.E.2    Ingerslev, H.J.3
  • 29
    • 0030139632 scopus 로고    scopus 로고
    • Epigenetic modifications during oocyte growth correlates with extenDed parthenogenetic Development in the mouse
    • Kono T, Obata Y, Yoshimzu T, Nakahara T, Carroll J. Epigenetic modifications during oocyte growth correlates with extenDed parthenogenetic Development in the mouse. Nat Genet 1996;13: 91-94
    • (1996) Nat Genet , vol.13 , pp. 91-94
    • Kono, T.1    Obata, Y.2    Yoshimzu, T.3    Nakahara, T.4    Carroll, J.5
  • 30
    • 84867668434 scopus 로고    scopus 로고
    • Maternal adiposity-A Determinant of perinatal and offspring outcomes?
    • Lawlor DA, Relton C, Sattar N, Nelson SM. Maternal adiposity-A Determinant of perinatal and offspring outcomes? Nat Rev Endocrinol 2012;8:679-688
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 679-688
    • Lawlor, D.A.1    Relton, C.2    Sattar, N.3    Nelson, S.M.4
  • 31
    • 0021264454 scopus 로고
    • Pyruvate and glucose uptake by mouse ova and preimplantation embryos
    • Leese HJ, Barton AM. Pyruvate and glucose uptake by mouse ova and preimplantation embryos. J Reprod Fertil 1984;72:9-13
    • (1984) J Reprod Fertil , vol.72 , pp. 9-13
    • Leese, H.J.1    Barton, A.M.2
  • 34
    • 79955021085 scopus 로고    scopus 로고
    • Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles
    • Marquard KL, Stephens SM, Jungheim ES, Ratts VS, ODem RR, Lanzendorf S, Moley KH. Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril 2011;95:2146-2149, 2149 e2141
    • (2011) Fertil Steril , vol.95 , pp. 2146-2149
    • Marquard, K.L.1    Stephens, S.M.2    Jungheim, E.S.3    Ratts, V.S.4    Odem, R.R.5    Lanzendorf, S.6    Moley, K.H.7
  • 35
    • 0035578226 scopus 로고    scopus 로고
    • Exogenous amino acids regulate trophectoDerm differentiation in the mouse blastocyst through an mTOR-DepenDent pathway
    • Martin PM, Sutherland AE. Exogenous amino acids regulate trophectoDerm differentiation in the mouse blastocyst through an mTOR-DepenDent pathway. Dev Biol 2001;240:182-193
    • (2001) Dev Biol , vol.240 , pp. 182-193
    • Martin, P.M.1    Sutherland, A.E.2
  • 36
    • 0027377533 scopus 로고
    • Activity of enzymes of energy metabolism in single human preimplantation embryos
    • Martin KL, Hardy K, Winston RM, Leese HJ. Activity of enzymes of energy metabolism in single human preimplantation embryos. J Reprod Fertil 1993;99:259-266
    • (1993) J Reprod Fertil , vol.99 , pp. 259-266
    • Martin, K.L.1    Hardy, K.2    Winston, R.M.3    Leese, H.J.4
  • 37
    • 59949103183 scopus 로고    scopus 로고
    • Disruption of mitochondrial malate-Aspartate shuttle activity in mouse blastocysts impairs viability and fetal growth
    • Mitchell M, Cashman KS, Gardner DK, Thompson JG, Lane M. Disruption of mitochondrial malate-Aspartate shuttle activity in mouse blastocysts impairs viability and fetal growth. Biol Reprod 2009;80:295-301
    • (2009) Biol Reprod , vol.80 , pp. 295-301
    • Mitchell, M.1    Cashman, K.S.2    Gardner, D.K.3    Thompson, J.G.4    Lane, M.5
  • 38
    • 84862994723 scopus 로고    scopus 로고
    • The effect of body mass inDex on the outcomes of first assisted reproductive technology cycles
    • Moragianni VA, Jones SM, Ryley DA. The effect of body mass inDex on the outcomes of first assisted reproductive technology cycles. Fertil Steril 2012;98:102-108
    • (2012) Fertil Steril , vol.98 , pp. 102-108
    • Moragianni, V.A.1    Jones, S.M.2    Ryley, D.A.3
  • 42
    • 79959659116 scopus 로고    scopus 로고
    • Effect of obesity on oocyte and embryo quality in women unDergoing in vitro fertilization
    • Shah DK, Missmer SA, Berry KF, Racowsky C, Ginsburg ES. Effect of obesity on oocyte and embryo quality in women unDergoing in vitro fertilization. Obstet Gynecol 2011;118:63-70
    • (2011) Obstet Gynecol , vol.118 , pp. 63-70
    • Shah, D.K.1    Missmer, S.A.2    Berry, K.F.3    Racowsky, C.4    Ginsburg, E.S.5
  • 43
    • 84875391877 scopus 로고    scopus 로고
    • Parallels between embryo and cancer cell metabolism
    • Smith DG, Sturmey RG. Parallels between embryo and cancer cell metabolism. Biochem Soc Trans 2013;41:664-669
    • (2013) Biochem Soc Trans , vol.41 , pp. 664-669
    • Smith, D.G.1    Sturmey, R.G.2
  • 44
    • 0042525896 scopus 로고    scopus 로고
    • Energy metabolism in pig oocytes and early embryos
    • Sturmey RG, Leese HJ. Energy metabolism in pig oocytes and early embryos. Reproduction 2003;126:197-204
    • (2003) Reproduction , vol.126 , pp. 197-204
    • Sturmey, R.G.1    Leese, H.J.2
  • 45
    • 57749179303 scopus 로고    scopus 로고
    • DNA damage and metabolic activity in the preimplantation embryo
    • Sturmey RG, Hawkhead JA, Barker EA, Leese HJ. DNA damage and metabolic activity in the preimplantation embryo. Hum Reprod 2009a; 24:81-91
    • (2009) Hum Reprod , vol.24 , pp. 81-91
    • Sturmey, R.G.1    Hawkhead, J.A.2    Barker, E.A.3    Leese, H.J.4
  • 46
    • 68349139217 scopus 로고    scopus 로고
    • Role of fatty acids in energy provision during oocyte maturation and early embryo Development
    • Sturmey RG, Reis A, Leese HJ, McEvoy TG. Role of fatty acids in energy provision during oocyte maturation and early embryo Development. Reprod Domest Anim 2009b;44(Suppl 3):50-58
    • (2009) Reprod Domest Anim , vol.44 , pp. 50-58
    • Sturmey, R.G.1    Reis, A.2    Leese, H.J.3    McEvoy, T.G.4
  • 47
    • 85006307269 scopus 로고    scopus 로고
    • Simplified technique for differential staining of inner cell mass and trophectoDerm cells of mouse and bovine blastocysts
    • Thouas GA, Korfiatis NA, French AJ, Jones GM, Trounson AO. Simplified technique for differential staining of inner cell mass and trophectoDerm cells of mouse and bovine blastocysts. Reprod Biomed Online 2001; 3:25-29
    • (2001) Reprod Biomed Online , vol.3 , pp. 25-29
    • Thouas, G.A.1    Korfiatis, N.A.2    French, A.J.3    Jones, G.M.4    Trounson, A.O.5
  • 48
    • 84870021505 scopus 로고    scopus 로고
    • BMI-related metabolic composition of the follicular fluid of women unDergoing assisted reproductive treatment and the consequences for oocyte and embryo quality
    • Valckx SD, De Pauw I, De Neubourg D, Inion I, Berth M, Fransen E, Bols PE, Leroy JL. BMI-related metabolic composition of the follicular fluid of women unDergoing assisted reproductive treatment and the consequences for oocyte and embryo quality. Hum Reprod 2012;27:3531-3539
    • (2012) Hum Reprod , vol.27 , pp. 3531-3539
    • Valckx, S.D.1    De Pauw, I.2    De Neubourg, D.3    Inion, I.4    Berth, M.5    Fransen, E.6    Bols, P.E.7    Leroy, J.L.8
  • 49
    • 0033646568 scopus 로고    scopus 로고
    • Intrafollicular influences on human oocyte Developmental competence: Perifollicular vascularity, oocyte metabolism and mitochondrial function
    • Van Blerkom J. Intrafollicular influences on human oocyte Developmental competence: perifollicular vascularity, oocyte metabolism and mitochondrial function. Hum Reprod 2000;15(Suppl 2):173-188
    • (2000) Hum Reprod , vol.15 , pp. 173-188
    • Van Blerkom, J.1
  • 52
    • 84862762138 scopus 로고    scopus 로고
    • Developmental reprogramming of cancer susceptibility
    • Walker CL, Ho SM. Developmental reprogramming of cancer susceptibility. Nat Rev Cancer 2012;12:479-486
    • (2012) Nat Rev Cancer , vol.12 , pp. 479-486
    • Walker, C.L.1    Ho, S.M.2
  • 53
    • 0025960202 scopus 로고
    • Meiotic competence acquisition is associated with the appearance of M-phase characteristics in growing mouse oocytes
    • Wickramasinghe D, Ebert KM, Albertini DF. Meiotic competence acquisition is associated with the appearance of M-phase characteristics in growing mouse oocytes. Dev Biol 1991;143:162-172
    • (1991) Dev Biol , vol.143 , pp. 162-172
    • Wickramasinghe, D.1    Ebert, K.M.2    Albertini, D.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.