Evidence that obesity alters the quality of oocytes and embryos

Pathophysiology

Volumn 15, Issue 2, 2008, Pages 115-121

  Robker, Rebecca L ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Assisted reproduction technologies (ART); Body mass index (BMI); Embryo; Female fertility; In vitro fertilization (IVF); Obesity; Oocyte

Indexed keywords

ROSIGLITAZONE;

BODY MASS; EMBRYO DEVELOPMENT; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; NIDATION; NONHUMAN; OBESITY; OOCYTE; PREGNANCY RATE; PRIORITY JOURNAL; REVIEW;

EID: 48349094724     PISSN: 09284680     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pathophys.2008.04.004     Document Type: Review

References (46)

1. Frisch R.E., and McArthur J.W. Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science 185 4155 (1974) 949-951
2. Rich-Edwards J.W., et al. Adolescent body mass index and infertility caused by ovulatory disorder. Am. J. Obstet. Gynecol. 171 1 (1994) 171-177
3. Ogden C.L., et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295 13 (2006) 1549-1555
4. Norman R.J., and Clark A.M. Obesity and reproductive disorders: a review. Reprod. Fertil. Dev. 10 1 (1998) 55-63
5. Metwally M., Li T.C., and Ledger W.L. The impact of obesity on female reproductive function. Obes. Rev. 8 6 (2007) 515-523
6. Linne Y. Effects of obesity on women's reproduction and complications during pregnancy. Obes. Rev. 5 3 (2004) 137-143
7. van der Steeg J.W., et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum. Reprod. 23 2 (2008) 324-328
8. Jensen T.K., et al. Fecundability in relation to body mass and menstrual cycle patterns. Epidemiology 10 4 (1999) 422-428
9. Fedorcsak P., et al. Impact of overweight and underweight on assisted reproduction treatment. Hum. Reprod. 19 11 (2004) 2523-2528
10. Fedorcsak P., et al. Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstet. Gynecol. Scand. 79 1 (2000) 43-48
11. Lashen H., Fear K., and Sturdee D.W. Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study. Hum. Reprod. 19 7 (2004) 1644-1646
12. Bellver J., et al. Obesity and assisted reproductive technology outcomes. Reprod. Biomed. Online 12 5 (2006) 562-568
13. Lintsen A.M., et al. Effects of subfertility cause, smoking and body weight on the success rate of IVF. Hum. Reprod. 20 7 (2005) 1867-1875
14. Wang J.X., Davies M., and Norman R.J. Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study. BMJ 321 7272 (2000) 1320-1321
15. Ferlitsch K., et al. Body mass index, follicle-stimulating hormone and their predictive value in in vitro fertilization. J. Assist. Reprod. Genet. 21 12 (2004) 431-436
16. Wass P., et al. An android body fat distribution in females impairs the pregnancy rate of in-vitro fertilization-embryo transfer. Hum. Reprod. 12 9 (1997) 2057-2060
17. Zaadstra B.M., et al. Fat and female fecundity: prospective study of effect of body fat distribution on conception rates. BMJ 306 6876 (1993) 484-487
18. Crosignani P.G., et al. Anthropometric indicators and response to gonadotrophin for ovulation induction. Hum. Reprod. 9 3 (1994) 420-423
19. Dokras A., et al. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet. Gynecol. 108 1 (2006) 61-69
20. Dor J., et al. The treatment of patients with polycystic ovarian syndrome by in-vitro fertilization and embryo transfer: a comparison of results with those of patients with tubal infertility. Hum. Reprod. 5 7 (1990) 816-818
21. Homburg R., et al. In vitro fertilization and embryo transfer for the treatment of infertility associated with polycystic ovary syndrome. Fertil. Steril. 60 5 (1993) 858-863
22. Urman B., et al. The outcome of in vitro fertilization and embryo transfer in women with polycystic ovary syndrome failing to conceive after ovulation induction with exogenous gonadotropins. Fertil. Steril. 57 6 (1992) 1269-1273
23. Maheshwari A., Stofberg L., and Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology-a systematic review. Hum. Reprod. Update 13 5 (2007) 433-444
24. Wittemer C., et al. Does body mass index of infertile women have an impact on IVF procedure and outcome?. J. Assist. Reprod. Genet. 17 10 (2000) 547-552
25. Carrell D.T., et al. Body mass index is inversely related to intrafollicular HCG concentrations, embryo quality and IVF outcome. Reprod. Biomed. Online 3 2 (2001) 109-111
26. van Swieten E.C., et al. Obesity and Clomiphene Challenge Test as predictors of outcome of in vitro fertilization and intracytoplasmic sperm injection. Gynecol. Obstet. Invest. 59 4 (2005) 220-224
27. Salha O., Dada T., and Sharma V. Influence of body mass index and self-administration of hCG on the outcome of IVF cycles: a prospective cohort study. Hum. Fertil. (Camb.) 4 1 (2001) 37-42
28. Metwally M., et al. Effect of increased body mass index on oocyte and embryo quality in IVF patients. Reprod. Biomed. Online 15 5 (2007) 532-538
29. Cano F., et al. Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women. J. Assist. Reprod. Genet. 14 5 (1997) 254-261
30. Wattanakumtornkul S., et al. Body mass index and uterine receptivity in the oocyte donation model. Fertil. Steril. 80 2 (2003) 336-340
31. Styne-Gross A., Elkind-Hirsch K., and Scott Jr. R.T. Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donation. Fertil. Steril. 83 6 (2005) 1629-1634
32. Zenke U., and Chetkowski R.J. Transfer and uterine factors are the major recipient-related determinants of success with donor eggs. Fertil. Steril. 82 4 (2004) 850-856
33. Bellver J., et al. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil. Steril. 88 2 (2007) 446-451
34. Bellver J., et al. Obesity and the risk of spontaneous abortion after oocyte donation. Fertil. Steril. 79 5 (2003) 1136-1140
35. Minge C.E., et al. Peroxisome proliferator-activated receptor gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality. Endocrinology (2008)
36. Clark A.M., et al. Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women. Hum. Reprod. 10 10 (1995) 2705-2712
37. Clark A.M., et al. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum. Reprod. 13 6 (1998) 1502-1505
38. C.E. Minge, R.L. Robker, R.J. Norman, PPAR Gamma: coordinating metabolic and immune contributions to female fertility, PPAR Res. 2008 (in press).
39. Lord J.M., Flight I.H., and Norman R.J. Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, d-chiro-inositol) for polycystic ovary syndrome. Cochr. Database Syst. Rev. 3 (2003) CD003053
40. Lewis C.G., et al. Failure of body mass index or body weight to influence markedly the response to ovarian hyperstimulation in normal cycling women. Fertil. Steril. 53 6 (1990) 1097-1099
41. Lashen H., et al. Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization. Hum. Reprod. 14 3 (1999) 712-715
42. Loveland J.B., et al. Increased body mass index has a deleterious effect on in vitro fertilization outcome. J. Assist. Reprod. Genet. 18 7 (2001) 382-386
43. Nichols J.E., et al. Extremes of body mass index reduce in vitro fertilization pregnancy rates. Fertil. Steril. 79 3 (2003) 645-647
44. Spandorfer S.D., et al. Obesity and in vitro fertilization: negative influences on outcome. J. Reprod. Med. 49 12 (2004) 973-977
45. Dechaud H., et al. Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer. Eur. J. Obstet. Gynecol. Reprod. Biol. 127 1 (2006) 88-93
46. Ku S.Y., et al. Clinical efficacy of body mass index as predictor of in vitro fertilization and embryo transfer outcomes. J. Korean Med. Sci. 21 2 (2006) 300-303