Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis

International Journal of Pharmaceutics

Volumn 491, Issue 1-2, 2015, Pages 367-374

  Kwok, Philip Chi Lip ^a   Grabarek, Adam ^b   Chow, Michael Y T ^a   Lan, Yun ^a   Li, Johnny C W ^a   Casettari, Luca ^c   Mason, A James ^d   Lam, Jenny K W ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF URBINO   (Italy)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antimicrobial peptides; Dry powder inhaler; Inhalation; Pulmonary delivery; Spray drying; Tuberculosis

Indexed keywords

DEXTRO ENANTIOMERIC POLYPEPTIDE ANTIBIOTIC AGENT; MANNITOL; POLYPEPTIDE ANTIBIOTIC AGENT; PYRAZINAMIDE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; AEROSOL; ANTIMICROBIAL CATIONIC PEPTIDE; EXCIPIENT; LAK120-A PEPTIDE; LAK120-HP13 PEPTIDE; POWDER;

AEROSOL; ALKALINITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISPERSION; DRUG ANALYSIS; DRUG CONFORMATION; DRUG FORMULATION; DRY POWDER; DRY POWDER INHALER; IN VITRO STUDY; LASER DIFFRACTION; LOADING DRUG DOSE; MELTING POINT; PARTICLE SIZE; PRIORITY JOURNAL; SOLID STATE; SPRAY DRYING; TUBERCULOSIS; WATER CONTENT; WETTABILITY; CHEMISTRY; DESICCATION; DRUG EFFECTS; MEDICINAL CHEMISTRY; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; POWDER;

AEROSOLS; ANTIMICROBIAL CATIONIC PEPTIDES; ANTITUBERCULAR AGENTS; CHEMISTRY, PHARMACEUTICAL; DESICCATION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRY POWDER INHALERS; EXCIPIENTS; MANNITOL; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PARTICLE SIZE; POWDERS;

EID: 84937022155     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.07.001     Document Type: Article

References (36)

1. M. Abedinzadeh, M. Gaeini, and S. Sardari Natural antimicrobial peptides against Mycobacterium tuberculosis J. Antimicrob. Chemother. 2015
2. H. Adi, D. Traini, H.K. Chan, and P.M. Young The influence of drug morphology on aerosolisation efficiency of dry powder inhaler formulations J. Pharm. Sci. 97 2008 2780 2788
3. S. Belotti, A. Rossi, P. Colombo, R. Bettini, D. Rekkas, S. Politis, G. Colombo, A.G. Balducci, and F. Buttini Spray dried amikacin powder for inhalation in cystic fibrosis patients: a quality by design approach for product construction Int. J. Pharm. 471 2014 507 515
4. British Pharmacopoeia Commission British Pharmacopoeia 2015 Stationery Office London England
5. K.L. Brown, and R.E. Hancock Cationic host defense (antimicrobial) peptides Curr. Opin. Immunol. 18 2006 24 30
6. W. Cao, Y. Xie, S. Krishnan, H. Lin, and M. Ricci Influence of process conditions on the crystallization and transition of metastable mannitol forms in protein formulations during lyophilization Pharm. Res. 30 2013 131 139
7. N.Y. Chew, and H.K. Chan The role of particle properties in pharmaceutical powder inhalation formulations J. Aerosol Med. 15 2002 325 330
8. A. Ghosh, R.K. Kar, J. Jana, A. Saha, B. Jana, J. Krishnamoorthy, D. Kumar, S. Ghosh, S. Chatterjee, and A. Bhunia Indolicidin targets duplex DNA: structural and mechanistic insight through a combination of spectroscopy and microscopy ChemMedChem 9 2014 2052 2058
9. P. Grieco, A. Carotenuto, L. Auriemma, M.R. Saviello, P. Campiglia, I.M. Gomez-Monterrey, L. Marcellini, V. Luca, D. Barra, E. Novellino, and M.L. Mangoni The effect of D-amino acid substitution on the selectivity of temporin L towards target cells: identification of a potent anti-Candida peptide Biochim. Biophys. Acta 1828 2013 652 660
10. H. Grohganz, Y.Y. Lee, J. Rantanen, and M. Yang The influence of lysozyme on mannitol polymorphism in freeze-dried and spray-dried formulations depends on the selection of the drying process Int. J. Pharm. 447 2013 224 230
11. G. Hao, Y.H. Shi, Y.L. Tang, and G.W. Le The intracellular mechanism of action on Escherichia coli of BF2-A/C, two analogues of the antimicrobial peptide Buforin 2 J. Microbiol. 51 2013 200 206
12. A.J. Hickey, A. Misra, and P.B. Fourie Dry powder antibiotic aerosol product development: inhaled therapy for tuberculosis J. Pharm. Sci. 102 2013 3900 3907
13. W.L. Hulse, R.T. Forbes, M.C. Bonner, and M. Getrost The characterization and comparison of spray-dried mannitol samples Drug Dev. Ind. Pharm. 35 2009 712 718
14. W.L. Hulse, R.T. Forbes, M.C. Bonner, and M. Getrost Influence of protein on mannitol polymorphic form produced during co-spray drying Int. J. Pharm. 382 2009 67 72
15. H. Jenssen, P. Hamill, and R.E. Hancock Peptide antimicrobial agents Clin. Microbiol. Rev. 19 2006 491 511
16. A.K. Kakkar, and N. Dahiya Bedaquiline for the treatment of resistant tuberculosis: promises and pitfalls Tuberculosis 94 2014 357 362
17. Y. Lan, J.T. Lam, G.K. Siu, W.C. Yam, A.J. Mason, and J.K. Lam Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis Tuberculosis 94 2014 678 689
18. X. Li, F.G. Vogt, D. Hayes Jr, and H.M. Mansour Design, characterization, and aerosol dispersion performance modeling of advanced spray-dried microparticulate/nanoparticulate mannitol powders for targeted pulmonary delivery as dry powder inhalers J. Aerosol Med. Pulm. Drug Deliv. 27 2014 81 93
19. W. Liang, M.Y. Chow, P.N. Lau, Q.T. Zhou, P.C. Kwok, G.P. Leung, A.J. Mason, H.K. Chan, L.L. Poon, and J.K. Lam Inhalable dry powder formulations of siRNA and pH-responsive peptides with antiviral activity against H1N1 influenza virus Mol. Pharm. 12 2015 910 921
20. W. Liang, P.C. Kwok, M.Y. Chow, P. Tang, A.J. Mason, H.K. Chan, and J.K. Lam Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids Eur. J. Pharm. Biopharm. 86 2014 64 73
21. Y.F. Maa, P.A. Nguyen, T. Sweeney, S.J. Shire, and C.C. Hsu Protein inhalation powders: spray drying vs spray freeze drying Pharm. Res. 16 1999 249 254
22. S. Matinkhoo, K.H. Lynch, J.J. Dennis, W.H. Finlay, and R. Vehring Spray-dried respirable powders containing bacteriophages for the treatment of pulmonary infections J. Pharm. Sci. 100 2011 5197 5205
23. J. Millard, C. Ugarte-Gil, and D.A. Moore Multidrug resistant tuberculosis BMJ 350 2015 h882
24. L.T. Nguyen, E.F. Haney, and H.J. Vogel The expanding scope of antimicrobial peptide structures and their modes of action Trends Biotechnol. 29 2011 464 472
25. A. Padhi, M. Sengupta, S. Sengupta, K.H. Roehm, and A. Sonawane Antimicrobial peptides and proteins in mycobacterial therapy: current status and future prospects Tuberculosis 94 2014 363 373
26. A. Peschel, and H.G. Sahl The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nature reviews Microbiology 4 2006 529 536
27. B.M. Peters, M.E. Shirtliff, and M.A. Jabra-Rizk Antimicrobial peptides: primeval molecules or future drugs PLoS Pathog. 6 2010 e1001067
28. G. Pilcer, and K. Amighi Formulation strategy and use of excipients in pulmonary drug delivery Int. J. Pharm. 392 2010 1 19
29. G. Saint-Lorant, P. Leterme, A. Gayot, and M.P. Flament Influence of carrier on the performance of dry powder inhalers Int. J. Pharm. 334 2007 85 91
30. A. Schuster, C. Haliburn, G. Doring, M.H. Goldman, and G. Freedom Study Safety, efficacy and convenience of colistimethate sodium dry powder for inhalation (Colobreathe DPI) in patients with cystic fibrosis: a randomised study Thorax 68 2013 344 350
31. J.D. Steckbeck, B. Deslouches, and R.C. Montelaro Antimicrobial peptides: new drugs for bad bugs Expert Opin. Biol. Ther. 14 2014 11 14
32. D. Traini, and P.M. Young Delivery of antibiotics to the respiratory tract: an update Expert Opin. Drug Deliv. 6 2009 897 905
33. L.S. Vermeer, Y. Lan, V. Abbate, E. Ruh, T.T. Bui, L.J. Wilkinson, T. Kanno, E. Jumagulova, J. Kozlowska, J. Patel, C.A. McIntyre, W.C. Yam, G. Siu, R.A. Atkinson, J.K. Lam, S.S. Bansal, A.F. Drake, G.H. Mitchell, and A.J. Mason Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic alpha-helical peptides J. Biol. Chem. 287 2012 34120 34133
34. WHO, 2014. Global Tuberculosis Report http://www.who.int/tb/publications/global-report/en/.
35. P.M. Young, and R. Price The influence of humidity on the aerosolisation of micronised and SEDS produced salbutamol sulphate Eur. J. Pharm. Sci. 22 2004 235 240
36. A.I. Zumla, S.H. Gillespie, M. Hoelscher, P.P. Philips, S.T. Cole, I. Abubakar, T.D. McHugh, M. Schito, M. Maeurer, and A.J. Nunn New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects Lancet Infect. Dis. 14 2014 327 340