A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis

American Journal of Respiratory Cell and Molecular Biology

Volumn 53, Issue 1, 2015, Pages 74-86

  Romero, Freddy ^a   Shah, Dilip ^a   Duong, Michelle ^a   Penn, Raymond B ^a   Fessler, Michael B ^b   Madenspacher, Jennifer ^b   Stafstrom, William ^a   Kavuru, Mani ^a   Lu, Bo ^b   Kallen, Caleb B ^a   Walsh, Kenneth ^c   Summer, Ross ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alveolar macrophages; Foam cells; Oxidized phospholipids; Pulmonary fibrosis; Type II pneumocytes

Indexed keywords

BLEOMYCIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LIPID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; SILICON DIOXIDE; TRANSFORMING GROWTH FACTOR BETA1; ABC TRANSPORTER; ABCG1 PROTEIN, HUMAN; ABCG1 PROTEIN, MOUSE; ANTINEOPLASTIC ANTIBIOTIC; LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FOAM CELL; LUNG ALVEOLUS CELL; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; LUNG LAVAGE; MACROPHAGE; MOUSE; NONHUMAN; PARACRINE SIGNALING; PHENOTYPE; RADIATION; ANIMAL; CHEMICALLY INDUCED; GENETICS; HUMAN; KNOCKOUT MOUSE; LIPID METABOLISM; METABOLISM; PATHOLOGY;

MURINAE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ATP-BINDING CASSETTE TRANSPORTERS; BLEOMYCIN; FOAM CELLS; HUMANS; LIPID METABOLISM; LIPOPROTEINS; MACROPHAGES, ALVEOLAR; MICE; MICE, KNOCKOUT; PHOSPHATIDYLCHOLINES; PNEUMOCYTES; PULMONARY FIBROSIS;

EID: 84937003117     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2014-0343OC     Document Type: Article

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