Inflammation and infections in asthma

Clinical Respiratory Journal

Volumn 9, Issue 3, 2015, Pages 257-269

  Gillissen, Adrian ^a   Paparoupa, Maria ^a  

^a Department for Pulmonary Medicine   (Germany)

Author keywords

Asthma; Asthma control; Bacteria; Infection; Virus

Indexed keywords

EOTAXIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 8; MACROPHAGE DERIVED CHEMOKINE; NITRIC OXIDE; PEPTIDOLEUKOTRIENE; PROSTAGLANDIN D2; RANTES; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

AIRWAY SMOOTH MUSCLE CELL; ANTIMICROBIAL THERAPY; ARTICLE; ASTHMA; BACTERIAL INFECTION; BACTERIUM DETECTION; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENVIRONMENTAL FACTOR; EPITHELIUM CELL; HAEMOPHILUS INFLUENZAE; HELICOBACTER PYLORI; HISTAMINE RELEASE; HUMAN; HYGIENE; IMMUNE RESPONSE; MAST CELL; MESENCHYMAL STEM CELL; MORAXELLA CATARRHALIS; NONHUMAN; PARASITOSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RESPIRATORY TRACT INFLAMMATION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; TH1 CELL; TH2 CELL; VIRUS INFECTION; AIRWAY REMODELING; COMPLICATION; INFLAMMATION; PATHOLOGY; PHYSIOLOGY; RESPIRATORY TRACT INFECTION;

AIRWAY REMODELING; ASTHMA; HUMANS; INFLAMMATION; RESPIRATORY TRACT INFECTIONS;

EID: 84936985608     PISSN: 17526981     EISSN: 1752699X     Source Type: Journal    
DOI: 10.1111/crj.12135     Document Type: Article

References (131)

1. GINA Executive and Science Committee, editor. Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. Bethesda, USA, US Department of Health and Human Services, 2012.
2. Koziol-White CJ, Panettieri RA Jr. Airway smooth muscle and immunomodulation in acute exacerbations of airway disease. Immunol Rev. 2011;242: 178-185.
3. Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, Wardlaw AJ, Pavord ID. Asthma exacerbations and sputum eosinophil counts: a randomized controlled trial. Lancet. 2002;360: 1715-1721.
4. Bjermer L. History and future perspectives of treating asthma as a systemic and small airways disease. Respir Med. 2001;95: 703-719.
5. Jeffery PK. Remodelling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2004;1: 176-183.
6. Hashimoto T, Akiyama K, Kawaguchi H, Maeda Y, Taniguchi M, Kobayashi N, Mori A. Correlation of allergen-induced IL-5 and IL-13 production by peripheral blood T cells of asthma patients. Int Arch Allergy Appl Immunol. 2004;134: 7-11.
7. Zangrilli JG, Peters SP. Cytokines in allgeric airway disease. In: Busse W, Holgate ST, editors. Asthma and Rhinitis. Cambridge, Blackwell Science Inc., 1999: 426-436.
8. Chuang-Stein C. Sample size and the probability of a successful trial. Pharm Stat. 2006;5: 305-309.
9. Sabroe I, Lloyd CM, Whyte MKB, Dower SK, Williams TJ, Pease JE. Chemokines, innate and adaptive immunity, and respiratory disease. Eur Respir J. 2002;19: 350-355.
10. Dahlén S-E. Cysteinyl leukotrienes as common mediators of asthma and allergic disease. Clin Exp Allergy Rev. 2003;3: 69-73.
11. Zhu Y, Chen L, Huang Z, Alkan S, Bunting KD, Wen R, Wang D, Huang H. Cutting edge: IL-5 primes the Th2 cytokine-producing capacity in eosinophils through a STAT5-dependent mechanism. J Immunol. 2004;173: 2918-2922.
12. Numata T, Konno A, Yamakoshi T, Hanazawa T, Terada N, Nagata H. Comparative role of peptide leukotrienes and histamine in the development of nasal mucosal swelling in nasal allergy. Ann Otol Rhinol Laryngol. 1999;108: 467-473.
13. Dweik RA, Sorkness RL, Wenzel S, etal. Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med. 2010;181: 1033-1041.
14. Boman G, Ludviksdottir D, Janson C, Högman M, Hedenström H, Björnsson E, Boman G. Exhaled nitric oxide and its relationship to airway responsiveness and atopy in asthma. Respir Med. 2008;93: 552-556.
15. Dressel H, de la Motte D, Reichert J, Ochmann U, Petru R, Angerer P, Holz O, Nowak D, Jörres RA. Exhaled nitric oxide: independent effects of atopy, smoking, respiratory tract infection, gender and height. Respir Med. 2008;102: 962-969.
16. Monneret G, Gravel S, Diamond M, Rokach J, Powell WS. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood. 2001;98: 1942-1948.
17. Mauad T, Bel EH, Sterk PJ. Asthma therapy and airway remodeling. J Allergy Clin Immunol. 2011;120: 997-1009.
18. Jeffery PK. Inflammation and remodeling in the adult and child with asthma. Pediatr Pulmonol Suppl. 2001;21: 3-16.
19. Palmans E, Kips JC, Pauwels RA. Prolonged allergen exposure induces structural airway changes in sensitized rats. Am J Respir Crit Care Med. 2000;161: 627-635.
20. Chetta A, Foresi A, Del Donno M, Bertorelli G, Pesci A, Olivieri D. Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest. 1997;111: 852-857.
21. Girodet PO, Ozier A, Bara I, Tunon de Lara JM, Marthan R, Berger P. Airway remodeling in asthma: new mechanisms and potential for pharmacological intervention. Pharmacol Ther. 2011;130: 325-337.
22. Bergeron C, Tulic MK, Hamid Q. Airway remodelling in asthma: from benchside to clinical practice. Can Respir J. 2010;17: e85-94.
23. Elias JA, Zhu Z, Chupp G, Homer RJ. Airway remodeling in asthma. Proc Am Thorac Soc. 2009;6: 301-305.
24. Murdoch JR, Lloyd CM. Chronic inflammation and asthma. Mutat Res. 2010;690: 24-39.
25. Payne DN, Rogers AV, Adelroth E, Bandi V, Guntupalli KK, Bush A, Jeffery PK. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med. 2003;167: 78-82.
26. Milanese M, Crimi E, Scordamaglia A, Riccio A, Pellegrino R, Canonica GW, Brusasco V. On the functional consequences of bronchial basement membrane thickening. J Appl Physiol. 2001;91: 1035-1040.
27. Laprise C, Laviolette M, Boutet M, Boulet L-P. Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodelling. Eur Respir J. 1999;14: 63-73.
28. Durant LR, Makris S, Voorburg CM, Loebbermann J, Johansson C, Openshaw PJ. Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during RSV infection in mice. J Virol. 2013;87: 10946-10954.
29. Robinson D. Regulatory T cells and asthma. Clin Exp Allergy. 2009;39: 1314-1323.
30. Eum S-Y, Maghni K, Hamid Q, Eidelman DH, Martin JG. Involvement of eotaxin and IL-5 in the development of antigen-induced airway eosinophilia but not in airway hyperresponsiveness in mice. Am J Respir Crit Care Med. 1999;159: A228.
31. Cieslewicz G, Tomkinson A, Adler A, Duez C, Schwarze J, Takeda K, Larson KA, Lee JJ, Irvin CG, Gelfand EW. The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration. J Clin Invest. 1999;104: 301-308.
32. Chiba Y, Sato S, Misawa M. Upregulation of geranylgeranyltransferase I in bronchial smooth muscle of mouse experimental asthma: its inhibition by lovastatin. J Smooth Muscle Res. 2010;46: 57-64.
33. James AL, Bai TR, Mauad T, Abramson MJ, Dolhnikoff M, McKay KO, Maxwell PS, Elliot JG, Green FH. Airway smooth muscle thickness in asthma is related to severity but not duration of asthma. Eur Respir J. 2009;34: 1040-1045.
34. Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P. Human airway smooth muscle promotes human lung mast cell survival proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol. 2008;181: 2772-2780.
35. Slats AM, Janssen LJ, Schadewijk VA, etal. Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma. J Allergy Clin Immunol. 2008;121: 1196-1292.
36. Sarir H, Henricks PAJ, Houwelingen AH, Nijkamp FP, Folkerts G. Cells, mediators and Toll-like receptors in COPD. Eur J Pharmacol. 2008;585: 346-353.
37. Camateros P, Tamaoka M, Hassan M, Marina R, Moisan J, Marion D, Guiot MC, Martin JG, Radzioch D. Chronic asthma-induced airway remodeling is prevented by Toll-like receptor-7/8 ligand S28463. Am J Respir Crit Care Med. 2007;175: 1241-1249.
38. Lien E, Ingalls RR. Toll-like receptors. Crit Care Med. 2002;30: S1-11.
39. Westergren-Thorsson G, Chakir J, Lafreniere-Allard MJ, Boulet LP, Tremblay GM. Correlation between airway responsiveness and proteoglycan production by bronchial fibroblasts from normal and asthmatic subjects. Int J Biochem Cell Biol. 2002;34: 1256-1267.
40. Postma DS, Timens W. Remodeling in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006;3: 434-439.
41. Suzuki R, Kato T, Miyazaki Y, Iwata M, Noda Y, Takagi K, Nakashima N, Torii K. Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in sputum from patients with bronchial asthma. J Asthma. 2001;38: 477-484.
42. Takeyama K, Fahy JV, Nadel JA. Relationship of epidermal growth factors to goblet cell production in human bronchi. Am J Respir Crit Care Med. 2001;163: 511-516.
43. Holgate ST. The airway epithelium is central to the pathogenesis of asthma. Allergol Int. 2008;57: 1-10.
44. Wu P, Dupont WD, Griffin MR, Carroll KN, Mitchel EF, Gebretsadik T, Hartert TV. Evidence of a causal role of winter virus infection during infancy in early childhood asthma. Am J Respir Crit Care Med. 2008;178: 1123-1129.
45. Hogg JC. Childhood viral infection and the pathogenesis of asthma and chronic obstructive lung disease. Am J Respir Crit Care Med. 1999;160: S26-28.
46. Papadopoulos NG, Christodoulou I, Rohde G, etal. Viruses and bacteria in acute asthma exacerbations - a GA2LEN-DARE systematic review. Allergy. 2011;66: 458-468.
47. Cooper PJ. Interactions between helminth parasites and allergy. Curr Opin Allergy Clin Immunol. 2009;9: 29-37.
48. Leonardi-Bee J, Pritchard D, Britton J. Asthma and current intestinal parasite infection: systematic review and meta-analysis. Am J Respir Crit Care Med. 2006;174: 514-523.
49. Illi S, von Mutius E, Lau S, Niggemann B, Grüber C, Wahn U. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006;368: 763-770.
50. Nickel R, Lau S, Niggemann B, Gruber C, von Mutius E, Illi S, Kulig M, Wahn U. Messages from the German multicentre allergy study. Pediatr Allergy Immunol. 2003;13: 7-10.
51. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ. 1993;310: 1225-1229.
52. Talbot TR, Hartert TV, Mitchel E, Halasa NB, Arbogast PG, Poehling KA, Schaffner W, Craig AS, Griffin MR. Asthma as a risk factor for invasive pneumococcal disease. N Engl J Med. 2005;352: 2082-2090.
53. Escobar GJ, Masaquel AS, Li S X, Walsh EM, Kipnis P. Persistent recurring wheezing in the fifth year of life after laboratory-confirmed, medically attended respiratory syncytial virus infection in infancy. BMC Pediatr. 2013;13: 97.
54. Papadopoulos NG, Johnston SL. Rhinoviruses as pathogens of the lower respiratory tract. Can Respir J. 2000;7: 409-414.
55. Becker S, Reed W, Henderson FW, Noah TL. RSV infection of human airway epithelial cells causes production of the beta-chemokine RANTES. Am J Physiol. 1997;273: L512-520.
56. Rochlitzer S, Hoymann HG, Muller M, Braun A. No exacerbation but impaired anti-viral mechanisms in a rhinovirus-chronic allergic asthma mouse model. Clin Sci (Lond). 2014;126: 55-65.
57. Jackson DJ, Gangnon RE, Evans MD, etal. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008;178: 667-672.
58. Gern JE, Lemanske RF Jr, Busse WW. Early life origins of asthma. J Clin Invest. 1999;104: 837-843.
59. Tager IB. The effects of second-hand and direct exposure to tobacco smoke on asthma and lung function in adolescence. Paediatr Respir Rev. 2008;9: 29-37.
60. Kusel MM, Klerk NH, Kebadze T, Vohma V, Holt PG. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol. 2007;119: 1105-1110.
61. Holt PG, Macaubas C, Stumbles PA, Sly PD. The role of allergy in the development of asthma. Nature. 1999;402: B12-17.
62. Holt PG. Infection and the development of allergic disease. Allergy. 2011;66: 13-15.
63. Martin JG, Siddigui S, Hassan M. Immune response to viral infections: relevance for asthma. Paediatr Respir Rev. 2006;7: S125-127.
64. Kimpen JLL. Viral infections and childhood asthma. Am J Respir Crit Care Med. 2000;162: S108-112.
65. Thomsen SF, van der Sluis S, Stensballe LG, Posthuma D, Skytthe A, Kyvik KO, Duffy DL, Backer V, Bisgaard H. Exploring the association between severe respiratory syncytial virus infection and asthma: a registry-based twin study. Am J Respir Crit Care Med. 2009;179: 1091-1097.
66. Jackson DJ, Johnston SL. The role of viruses in acute exacerbations of asthma. J Allergy Clin Immunol. 2010;125: 1178-1187.
67. Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL, Custovic A. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax. 2006;61: 376-382.
68. Leung TF, Chan PK, Wong GW, Fok TF, Ng PC. Respiratory viruses and atypical bacteria triggering severe asthma exacerbation in children. Hong Kong Med J. 2013;19(Suppl. 4): 11-14.
69. O'Callaghan-Gordo C, Bassat Q, Diez-Padrisa N, Morais L, Machevo S, Nhampossa T, Quinto L, Alonso PL, Roca A. Lower respiratory tract infections associated with Rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study. PLoS ONE. 2013;8: e69370.
70. Johnston SL, Pattemore PK, Sanderson G, etal. The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med. 1996;154: 654-660.
71. Heymann PW, Carper HT, Murphy DD, etal. Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. J Allergy Clin Immunol. 2004;114: 239-247.
72. Corne JM, Marshall C, Smith S, Schreiber J, Sanderson G, Holgate ST, Johnston SL. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet. 2002;359: 831-834.
73. Sachs AP, Sachs A, van Loon AM, Haarman M, van de Vijver DA, Kimman TG, Zuithoff P, Schipper PJ, Verheij TJ, Nijhuis M. Enhanced severity of virus associated lower respiratory tract disease in asthma patients may not be associated with delayed viral clearance and increased viral load in the upper respiratory tract. J Clin Virol. 2011;41: 116-121.
74. Gill MA, Bajwa G, George TA, Dong CC, Dougherty I, Jiang N, Gan VN, Gruchalla RS. Counterregulation between the Fc epsilon RI pathway and antiviral responses in human plasmacytoid dendritic cells. J Immunol. 2010;184: 5999-6006.
75. Kuo CH, Kuo HF, Huang CH, Yang SN, Lee MS, Hung CH. Early life exposure to antibiotics and the risk of childhood allergic diseases: an update from the perspective of the hygiene hypothesis. J Microbiol Immunol Infect. 2013;46: 320-329.
76. Okada H, Kuhn C, Feillet H, Bach J-F. The 'hygiene hypothesis' for autoimmune and allergic diseases: an update. Clin Exp Immunol. 2010;160: 1-9.
77. Martinez F, Wright A, Taussig L, Holberg C, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. N Engl J Med. 1995;332: 133-138.
78. Martinez FD, Stern DA, Wright AL, Taussig LM, Halonen M. Association of non-wheezing lower respiratory tract illnesses in early life with persistently diminished serum IgE levels. Thorax. 1994;50: 1067-1072.
79. Schaub B, Liu J, Höppler S, Schleich I, Hühn J, Olek S, Wieczorek G, Illi S, von Mutius E. Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol. 2009;123: 774-782.
80. Kabesch M, Lauener RP. Why Old McDonald had a farm but no allergies: genes, environments, and the hygiene hypothesis. J Leukoc Biol. 2004;75: 383-387.
81. Shirakawa T, Enomoto T, Shimazu S, Hopkin J. The inverse association between tuberculin response and atopic disorder. Science. 1997;275: 77-79.
82. Matricardi PM. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: controversial aspects of the 'hygiene hypothesis'. Clin Exp Immunol. 2010;160: 98-105.
83. Platts-Mills TA, Woodfolk JA, Sporik RB. The increase in asthma cannot be ascribed to cleanliness. Am J Respir Crit Care Med. 2001;164: 1107-1108.
84. Matricardi PM, Bouygue GR, Tripodi S. Inner-city asthma and the hygiene hypothesis. Ann Allergy Asthma Immunol. 2002;89: 69-74.
85. Kramer A, Bekeschus S, Broker BM, Schleibinger H, Razavi B, Assadian O. Maintaining health by balancing microbial exposure and prevention of infection: the hygiene hypothesis versus the hypothesis of early immune challenge. J Hosp Infect. 2013;83(Suppl. 1): S29-34.
86. Holt PG, Sly PD. Prevention of allergic respiratory disease in infants: current aspects and future perspectives. Curr Opin Allergy Clin Immunol. 2007;7: 547-555.
87. Starkey MR, Nguyen DH, Kim RY, Nair PM, Brown AC, Essifie AT, Horvat JC, Hansbro PM. Programming of the lung in early life by bacterial infections predisposes to chronic respiratory disease. Clin Obstet Gynecol. 2013;56: 566-576.
88. Metz G, Kraft M. Effects of atypical infections with mycoplasma and chlamydia on asthma. Immunol Allergy Clin North Am. 2010;30: 575-585.
89. Tompkins LS, Schachter J, Boman J, etal. Collaborative multidisciplinary workshop report: detection, culture, serology, and antimicrobial susceptibility testing of Chlamydia pneumoniae. J Infect Dis. 2000;181: S460-461.
90. Ferrari M, Poli A, Olivieri M, Verlato G, Tardivo S, Nicolis M, Campello C. Respiratory symptoms, asthma, atopy and chlamydia pneumoniae IgG antibodies in a general population sample of young adults. Infection. 2002;30: 203-207.
91. Johansson N, Kalin M, Tiveljung-Lindell-Giske CG, Hedlund J. Etiology of community-acquired pneumonia: increased microbiological yield with new diagnostic methods. Clin Infect Dis. 2010;50: 202-209.
92. Kern DG, Neill MA, Schachter J. A seroepidemiologic study of chlamydia pneumoniae in Rhode Island. Evidence of serologic cross-reactivity. Chest. 1993;104: 208-213.
93. Goldschmidt P, Rostane H, Sow M, Goépogui A, Batellier L, Chaumeil C. Detection by broad-range real-time PCR assay of Chlamydia species infecting human and animals. Br J Ophthalmol. 2006;90: 1425-1429.
94. Patel KK, Vicencio AG, Du Z, Tsirilakis K, Salva PS, Webley WC. Infectious chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma. Pediatr Infect Dis. 2010;29: 1093-1098.
95. Franco RR, Bodanese LC, Repetto G, Piccoli Ida C, Wiehe M, Bonato C, Duarte MM, Duarte T. Inflammatory markers and antichlamydial antibodies in patients with metabolic syndrome. Arq Bras Cardiol. 2011;96: 134-139.
96. Guerders MM, Foidart JM, Noel A, Cataldo DD. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: potential implications in asthma and other lung diseases. Eur J Pharmacol. 2006;533: 133-144.
97. Demedts IK, Brusselle GG, Bracke KR, Vermaelen KY, Pauwels RA. Matrix metalloproteinases in asthma and COPD. Curr Opin Pharmacol. 2005;5: 257-263.
98. Olivares-Zavaleta N, Carmody A, Messer R, Whitmire WM, Caldwell HD. Chlamydia pneumoniae inhibits activated human T lymphocyte proliferation by the induction of apoptotic and pyroptotic pathways. J Immunol. 2011;186: 7120-7126.
99. Kern JM, Maass V, Maass M. Chlamydia pneumoniae adversely modulates vascular cell properties by direct interaction with signalling cascades. Thromb Haemost. 2009;102: 1064-1070.
100. Johnston SL, Martin RJ. Chlamydophila pneumoniae and mycoplasma pneumoniae: a role in asthma pathogenesis? Am J Respir Crit Care Med. 2005;172: 1078-1089.
101. Jackson DJ, Sykes A, Mallia P, Johnston SL. Asthma exacerbations: origin, effect, and prevention. J Allergy Clin Immunol. 2011;128: 1165-1174.
102. Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J Immunol. 2010;184: 4159-4169.
103. Crother TR, Schröder NW, Karlin J, Chen S, Shimada K, Slepenkin A, Alsabeh R, Peterson E, Arditi M. Chlamydia pneumoniae infection induced allergic airway sensitization is controlled by regulatory T-cells and plasmacytoid dendritic cells. PLoS ONE. 2011;6: e20784.
104. Klapdor B, Ewig S, Pletz MW, Rohde G, Schütte H, Schaberg T, Welte T. Community-acquired pneumonia in the younger is an entity of its own. Eur Respir J. 2012;39: 1156-1161.
105. Pientong C, Ekalaksanan T, Teeratakulpisam J, Tanuwattanachai S, Kongyingyoes B, Limwattananon C. Atypical bacterial pathogen infection in children with acute bronchiolitis in northeast Thailand. J Microbiol Immunol Infect. 2011;44: 95-100.
106. Neumark T, Ekblom M, Brudin L, Groth A, Eliasson I, Mölstad S, Petersson AC, Törngren A. Spontaneously draining acute otitis media in children: an observational study of clinical findings, microbiology and clinical course. Scand J Infect Dis. 2011;43: 891-898.
107. Niang M, Diallo M, Cisse O, Kone M, Doucoure M, Roth JA, Balcer-Rodrigues V, Dedieu L. Pulmonary and serum antibody responses elicited in zebu cattle experimentally infected with Mycoplasma mycoides subsp. mycoides SC by contact exposure. Vet Res. 2006;37: 733-744.
108. Esposito S, Principi N. Asthma in children: are chlamydia or mycoplasma involved? Paediatr Drugs. 2001;3: 159-168.
109. Cosentini R, Tarsia P, Canett C, Graziadei G, Brambilla AM, Aliberti S, Pappalettera M, Tantardini F, Blais F. Severe asthma exacerbation: role of acute chlamydophila pneumoniae and mycoplasma pneumoniae infection. Respir Res. 2008;30: 48.
110. Martin RJ. Infections and asthma. Clin Chest Med. 2006;27: 87-98.
111. Tsai HF, Hsu PN. Interplay between helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology. Cell Mol Immunol. 2010;7: 255-259.
112. Arnold IC, Dehzad N, Reuter S, Martin H, Becker B, Taube C, Müller A. Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest. 2011;121: 3088-3093.
113. Sevin CM, Peebles RS Jr. Infections and asthma: new insights into old ideas. Clin Exp Allergy. 2010;40: 1142-1154.
114. McLoughlin RM, Mills KH. Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma. J Allergy Clin Immunol. 2010;127: 1097-1107.
115. El-Outob López D. New methods of prevention and treatment of allergic diseases. Recent Pat Inflamm Allergy Drug Discov. 2012;6: 46-64.
116. Vanderhoof JA, Mitmesser SH. Probiotics in the management of children with allergy and other disorders of intestinal inflammation. Benef Microbes. 2012;1: 351-356.
117. Pastacaldi C, Lewis P, Howarth P. Staphylococci and staphylococcal superantigens in asthma and rhinitis: a systematic review and meta-analysis. Allergy. 2011;66: 549-555.
118. Bachert C, Gevaert P, Zhang N, Zele VT, Perez-Novo C. Role of staphylococcal superantigens in airway disease. Chem Immunol Allergy. 2007;93: 214-236.
119. Schwerk N, Brinkmann F, Soudah B, Kabesch M, Hansen G. Wheeze in preschool age is associated with pulmonary bacterial infection and resolves after antibiotic therapy. PLoS ONE. 2011;6: e27913.
120. Bisgaard H, Hermansen MN, Buchvald F, etal. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med. 2007;357: 1487-1495.
121. Essilfie AT, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, Gibson PG, Hansbro PM. Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease. PLoS Pathog. 2011;7: e100224.
122. Busse WW. Asthma diagnosis and treatment: filling in the information gaps. J Allergy Clin Immunol. 2011;128: 740-750.
123. Gonem S, Desai D, Siddiqui S, Brightling CC. Evidence for phenotype-driven treatment in asthmatic patients. Curr Opin Allergy Clin Immunol. 2011;11: 381-385.
124. Zarogoulides P, Papanas N, Kioumis I, Chatzaki E, Maltezos E, Zarogoulidis K. Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. Eur J Clin Pharmacol. 2012;68: 479-503.
125. Friedlander AL, Albert RK. Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. Chest. 2010;138: 1202-1212.
126. Good JT Jr, Rollins DR, Martin RJ. Macrolides in the treatment of asthma. Curr Opin Pulm Med. 2012;18: 76-84.
127. Hernando-Sastre V. Macrolide antibiotics in the treatment of asthma: an update. Allergol Immunopathol (Madr). 2010;38: 92-98.
128. Jedrychowski W, Perera F, Maugeri U, Mroz E, Flak E, Perzanowski M, Majewska R. Wheezing and asthma may be enhanced by broad spectrum antibiotics used in early childhood. Concept and results of a pharmacoepidemiology study. J Physiol Pharmacol. 2011;62: 189-195.
129. Murk W, Risnes KR, Bracken MB. Prenatal or early-life exposure to antibiotics and risk of childhood asthma: a systematic review. Pediatrics. 2011;127: 1125-1138.
130. Lundy SK, Lukacs NW. Chronic schistosome infection leads to modulation of granuloma formation and systemic immune suppression. Front Immunol. 2013;4: 39.
131. Flohr C, Quinnell RJ, Britton J. Do helminth parasites protect against atopy and allergic disease? Clin Exp Allergy. 2009;39: 20-32.