Correlation of allergen-induced IL-5 and IL-13 production by peripheral blood T cells of asthma patients

International Archives of Allergy and Immunology

Volumn 134, Issue SUPPL. 1, 2004, Pages 7-11

  Hashimoto, Tomomi ^a   Akiyama, Kazuo ^a   Kawaguchi, Hiroshi ^a   Maeda, Yuji ^a   Taniguchi, Masami ^a   Kobayashi, Noriaki ^b   Mori, Akio ^a,c  

^a SAGAMIHARA NATIONAL HOSPITAL   (Japan)

^b Tokyo Technical College   (Japan)

^c NONE   (Japan)

Author keywords

Atopic dermatitis; Bronchial asthma; IL 13; IL 5; T cell

Indexed keywords

ALLERGEN; CALCIUM IONOPHORE; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; PARASITE ANTIGEN; PHORBOL ESTER;

ADULT; ASTHMA; ATOPIC DERMATITIS; CELL CULTURE; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DERMATOPHAGOIDES FARINAE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE;

ADULT; ALLERGENS; ANTIGENS, DERMATOPHAGOIDES; ASTHMA; CELLS, CULTURED; DERMATITIS, ATOPIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-5; T-LYMPHOCYTES;

EID: 2642536720     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000077786     Document Type: Conference Paper

References (14)

1. Renauld JC: New insight into the role of cytokines in asthma. J Clin Pathol 2001;54:577-589.
2. Hamelmann E, Gelfand EW: IL-5-induced airway eosinophilia - The key to asthma? Immunol Rev 2001;179:182-191.
3. Kay AB: 'Helper' (CD4+) T cells and eosinophils in allergy and asthma. Am Rev Respir Dis 1992;145:S22-S26.
4. Kristin M: Eosinophils in atopic dermatitis. J Allergy Clin Immunol 1994;4:310-317.
5. Dolganov G, Bort S, Lovett M, Burr J, Schubert L, Short D, McGurn M, Gibson C, Lewis DB: Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. Blood 1996;87:3316-3326.
6. Van der Pouw Kraan TC, Boeije LC, Troon JT, Rutschmann SK, Wijdenes J, Aardenman LA: Human IL-13 production is negatively influenced by CD3 engagement: Enhancement of IL-13 production by cyclosporin A. J Immunol 1996;156:1818-1823.
7. Minty A, Asselin S, Bensussan A, Shire D, Vita N, Vyakarmam A, Wijdenes J, Ferrara P, Caput D: The related cytokines interleukin 13 and interleukin 4 are distinguished by differential production and differential effects on T lymphocytes. Eur Cytokine Netw 1997;8:203-213.
8. Mori A, Yamamoto K, Dohi M, Suko M, Okudaira H: Interleukin-4 gene expression in human peripheral blood mononuclear cells. Int Arch Allergy Appl Immunol 1995;95:282-284.
9. Mori A, Suko M, Nishizaki Y, Kaminuma O, Kobayashi S, Matsuzaki G, Yamamoto K, Ito K, Tsuruoka N, Okudaira H: IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and immunosuppressants FK506 and cyclosporin A. Int Immunol 1995;7:449-457.
10. Li Y, Simons FE, HayGlass KT: Environmental antigen-induced IL-13 responses are elevated among subjects with allergic rhinitis, are independent of IL-4, and are inhibited by endogenous IFN-gamma synthesis. J Immunol 1998;161:7007-7014.
11. Mori A, Kaminuma O, Suko M, Mikami T, Nishizaki Y, Ohmura T, Hoshino A, Asakura Y, Miyazawa K, Ando T, Okumura Y, Yamamoto K, Okudaira H: Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: A study with allergen-specific human helper T cells. J Allergy Clin Immunol 1997;100:S56-S64.
12. Wynn TA: IL-13 effector functions. Annu Rev Immunol 2003;21:425-456.
13. Mori A, Suko M, Kaminuma O, Nishizaki Y, Mikami T, Ohmura T, Hoshino A, Inoue S, Tsuruoka N, Okumura Y, Sato G, Ito K, Okudaira H: A critical role of IL-2 for the production and gene transcription of IL-5 in allergenspecific human T cell clones. Int Immunol 1996;8:1889-1895.
14. Verheyen J, Bonig H, Kim TM, Banning U, Mauz-Korholz C, Kramm C, Korholz D: Regulation of interleukin-2 induced interleukin-5 and interleukin-13 production in human peripheral blood mononuclear cells. Scand J Immunol 2000;51/1:45-53.